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2007
Acute lymphoblastic leukemias (ALLs) are a group of hematological neoplasias defined by cytomorphology, cytochemistry, immunological markers, and more recently, molecular markers. The prognosis of ALL has much improved in the last 30 yr, especially in the age group between 2 and 10 yr, where most patients can be cured by chemotherapy.
Vishwas S. Sakhalkar, Reinhold Munker
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Acute lymphoblastic leukemias (ALLs) are a group of hematological neoplasias defined by cytomorphology, cytochemistry, immunological markers, and more recently, molecular markers. The prognosis of ALL has much improved in the last 30 yr, especially in the age group between 2 and 10 yr, where most patients can be cured by chemotherapy.
Vishwas S. Sakhalkar, Reinhold Munker
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Recent advances in the treatment of acute lymphoblastic leukemia
Leukemia and Lymphoma, 2019Acute lymphoblastic leukemia (ALL) is a heterogeneous disease with a bimodal distribution. The progresses made in understanding its biology led to the development of targeted therapies.
H. Rafei, H. Kantarjian, E. Jabbour
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Pharmacogenomics of acute lymphoblastic leukemia
Current Opinion in Hematology, 2006The cure rate in children with acute lymphoblastic leukemia now exceeds almost 80% in most treatment protocols in industrialized countries. This has mainly been achieved empirically through carefully controlled, randomized clinical trials. Due to relative nonspecific action and narrow therapeutic indices of antileukemic medications, however, current ...
William E. Evans, Leo Kager
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Acute lymphoblastic leukemia in adults
Current Treatment Options in Oncology, 2000The therapy of acute lymphoblastic leukemia (ALL) in adults has built on the remarkable success achieved in the treatment of this disease in children. However, older age and other adverse risk factors seen more commonly in adults than in children have lessened the success of the treatment of ALL in comparison with what has been achieved in children ...
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Acute Lymphoblastic Leukemia of Childhood
Hematology/Oncology Clinics of North America, 1987Over the last 20 years, the rate of long-term disease-free survival of childhood acute lymphoblastic leukemia increased from less than 1 to 60 per cent. Strategies for disease control include (1) intensive multiagent induction to rapidly decrease the tumor burden and minimize the chance of emergence of a resistant population of cells, (2) restoration ...
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Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Science, 2004A. Weng +8 more
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Acute lymphoblastic leukemia in children
Current Opinion in Oncology, 2000As the overall long-term event-free survival rate in children with acute lymphoblastic leukemia approaches 80%, emphasis is being placed on risk-directed therapy so that patients are neither overtreated nor undertreated. It has become apparent that a risk assignment system based on primary genetic abnormalities is inadequate by itself.
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Acute Lymphoblastic Leukemia in Children and Adolescents
The EBMT Handbook, 2018Christina Peters +2 more
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Acute lymphoblastic leukemia in infancy
Pediatric Blood & Cancer, 2007Infant ALL is uncommon, biologically distinctive from the disease in older children, and associated with a relatively poor prognosis. Adverse prognostic factors include the presence of an MLL gene rearrangement (observed in up to 80% of infants with ALL), younger age at diagnosis, high presenting leukocyte counts, and slow early response to therapy ...
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