Results 31 to 40 of about 401,465 (309)

Inotuzumab Ozogamicin versus Standard Therapy for Acute Lymphoblastic Leukemia.

New England Journal of Medicine, 2016
BACKGROUND The prognosis for adults with relapsed acute lymphoblastic leukemia is poor. We sought to determine whether inotuzumab ozogamicin, an anti-CD22 antibody conjugated to calicheamicin, results in better outcomes in patients with relapsed or ...
H. Kantarjian, D. DeAngelo, M. Stelljes, G. Martinelli, M. Liedtke, W. Stock, N. Gökbuget, S. O'brien, Kongming Wang, Tao Wang, M. L. Paccagnella, B. Sleight, E. Vandendries, A. Advani   +13 more
semanticscholar   +1 more source

Treatment of Adult Patients with Relapsed/Refractory B-Cell Philadelphia-Negative Acute Lymphoblastic Leukemia [PDF]

, 2019
The majority of adult patients affected by B-cell acute lymphoblastic leukemia (B-ALL) will relapse after an initial response, while approximately 20% will display primary resistant disease. Patients suffering from relapsed/refractory B-ALL have a very
Lanza, Francesco, Maffini, Enrico, Saraceni, Francesco   +2 more
core   +1 more source

Association of ARID5B gene variants with acute lymphoblastic leukemia in Yemeni children

Tumor Biology, 2017
Studies have shown an association between ARID5B gene polymorphisms and childhood acute lymphoblastic leukemia. However, the association between ARID5B variants and acute lymphoblastic leukemia among the Arab population still needs to be studied. The aim
Boshra Al-absi, Suzita M Noor, Riyadh Saif-Ali, Sameer D Salem, Radwan H Ahmed, Muhammad FM Razif, Sekaran Muniandy   +6 more
doaj   +1 more source

The role of ZAP70 kinase in acute lymphoblastic leukemia infiltration into the central nervous system

Haematologica, 2017
Central nervous system infiltration and relapse are poorly understood in childhood acute lymphoblastic leukemia. We examined the role of zeta-chain-associated protein kinase 70 in preclinical models of central nervous system leukemia and performed ...
Ameera Alsadeq, Henning Fedders, Christian Vokuhl, Nele M. Belau, Martin Zimmermann, Tim Wirbelauer, Steffi Spielberg, Michaela Vossen-Gajcy, Gunnar Cario, Martin Schrappe, Denis M. Schewe   +10 more
doaj   +1 more source

Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia.

Cancer Discovery, 2016
UNLABELLED Chimeric antigen receptor (CAR)-modified T cells with anti-CD19 specificity are a highly effective novel immune therapy for relapsed/refractory acute lymphoblastic leukemia.
D. Teachey, D. Teachey, S. Lacey, P. Shaw, J. Melenhorst, S. Maude, N. Frey, E. Pequignot, V. Gonzalez, Fang Chen, J. Finklestein, D. Barrett, S. Weiss, J. Fitzgerald, R. Berg, R. Aplenc, C. Callahan, S. Rheingold, Zhaohui Zheng, S. Rose-John, J. White, Farzana Nazimuddin, G. Wertheim, B. Levine, C. June, D. Porter, S. Grupp   +26 more
semanticscholar   +1 more source

Targeting the phosphatidylinositol 3-kinase/Akt/mechanistic target of rapamycin signaling pathway in B-lineage acute lymphoblastic leukemia: An update [PDF]

, 2018
Despite considerable progress in treatment protocols, B-lineage acute lymphoblastic leukemia (B-ALL) displays a poor prognosis in about 15–20% of pediatric cases and about 60% of adult patients. In addition, life-long irreversible late effects from chemo-
Capitani, Silvano, Martelli, Alberto M., McCubrey, James A., Neri, Luca M., Simioni, Carolina, Vitale, Marco, Zauli, Giorgio   +6 more
core   +1 more source

Acute lymphoblastic leukemia: a comprehensive review and 2017 update

Blood Cancer Journal, 2017
Acute lymphoblastic leukemia (ALL) is the second most common acute leukemia in adults, with an incidence of over 6500 cases per year in the United States alone.
T. Terwilliger, M. Abdul-Hay
semanticscholar   +1 more source

Factors associated with a prolonged hospital stay during induction chemotherapy in newly diagnosed high risk pediatric acute lymphoblastic leukemia [PDF]

, 2018
Background High Risk (HR) or Very High Risk (VHR) acute lymphoblastic leukemia (ALL) treated with 4 drug induction chemotherapy is often associated with adverse events.
Althouse, Sandra K., Batra, Sandeep, Rahrig, April, Rupenthal, Joy, Warrick, Kasper   +4 more
core   +1 more source

Poor Prognosis Biomolecular Factors Are Highly Frequent in Childhood Acute Leukemias From Oaxaca, Mexico

Technology in Cancer Research & Treatment, 2020
Objective: To investigate the cellular and molecular epidemiology of acute leukemias in vulnerable populations of children and adolescents in Oaxaca de Juarez, Mexico.
Gerardo Juárez-Avendaño MSc, Nuria Citlalli Luna-Silva MD, Euler Chargoy-Vivaldo MD, Laura Alicia Juárez-Martínez MD, Mayra Noemí Martínez-Rangel BS, Noemí Zárate-Ortiz BS, Edith Martínez-Valencia BS, Briceida López-Martínez MD, Rosana Pelayo PhD, Juan Carlos Balandrán PhD   +9 more
doaj   +1 more source

Acute Lymphoblastic Leukemia Presenting with Right Atrial Thrombosis and Massive Pulmonary Embolism: A Case Report

Middle East Journal of Cancer, 2020
Thrombosis is a rare complication of acute lymphoblastic leukemia usually occurring following chemotherapy. The most common reported site is intracranial thrombosis.
Amirataollah Hiradfar, Shamsi Ghaffari, Soroush Mostafavi   +2 more
doaj   +1 more source