Results 41 to 50 of about 223,598 (343)

Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia

Haematologica, 2011
The runt-related transcription factor 1, RUNX1, is crucial in the development of myeloid and lymphoid cell lineages and has been reported to be mutated in myeloid malignancies in approximately 30% of cases.
Vera Grossmann, Wolfgang Kern, Stefan Harbich, Tamara Alpermann, Sabine Jeromin, Susanne Schnittger, Claudia Haferlach, Torsten Haferlach, Alexander Kohlmann   +8 more
doaj   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

A case report of secondary B-cell acute lymphoblastic leukemia treated with a combination of FLT3 inhibitor and decitabine

Frontiers in Oncology
Secondary acute lymphoblastic leukemia (s-ALL) refers to acute lymphoblastic leukemia that occurs after a previous malignant tumor, including therapy-related acute lymphoblastic leukemia (t-ALL) and prior malignant tumor acute lymphoblastic leukemia (pm ...
Mengci Hu, Wenzhe Li, Pan Li, Jie Tan, Ya Wang, Ya Wang   +5 more
doaj   +1 more source

Correlation of Serum Lipoproteins with the Activity of Acute Lymphoblastic Leukaemia

مجله كليه طب الكندي, 2019
Background: the activity of acute lymphoblastic leukemia had been observed to correlate with levels of serum lipoproteins Objective: to evaluate the correlation of serum levels of different types of lipoproteins with activity of the disease in ...
Azher Sebieh Al-Zubaidy
doaj   +1 more source

Prenatal origin of childhood AML occurs less frequently than in childhood ALL [PDF]

, 2006
Background While there is enough convincing evidence in childhood acute lymphoblastic leukemia (ALL), the data on the pre-natal origin in childhood acute myeloid leukemia (AML) are less comprehensive.
AM Ford, AT Maia, AT Maia, AT Maia, Bjoern Schneider, C Meyer, Claus Meyer, CM McHale, CM McHale, Felix Votava, GS Makowski, H Kempski, H Kiyoi, J Zuna, Jan Stary, Jan Trka, Jan Zuna, JL Wiemels, JL Wiemels, JL Wiemels, JL Wiemels, Jozef Madzo, JW Taub, K Fasching, Katerina Muzikova, KB Gale, KE Richkind, LK Jones, LL Hjalgrim, LY Shih, MD Megonigal, MF Greaves, MJ Pongers-Willemse, N Goulden, PD Kottaridis, Rolf Marschalek, S Meshinchi, SA Miller, SC Raimondi, T Szczepanski, T Yagi, Tatiana Burjanivova   +41 more
core   +3 more sources

The prognosis of CALM-AF10-positive adult T-cell acute lymphoblastic leukemias depends on the stage of maturation arrest

Haematologica, 2013
CALM-AF10 (also known as PICALM-MLLT10) is the commonest fusion protein in T-cell acute lymphoblastic leukemia, but its prognostic impact remains unclear.
Raouf Ben Abdelali, Vahid Asnafi, Arnaud Petit, Jean-Baptiste Micol, Céline Callens, Patrick Villarese, Eric Delabesse, Oumedaly Reman, Stephane Lepretre, Jean-Yves Cahn, Gaelle Guillerm, Céline Berthon, Claude Gardin, Bernadette Corront, Thibaut Leguay, Marie-Christine Béné, Norbert Ifrah, Guy Leverger, Hervé Dombret, Elizabeth Macintyre   +19 more
doaj   +1 more source

Multilineage Lymphoblastic Lymphoma as an Initial Presentation of Mixed Phenotype Acute Leukemia

Case Reports in Hematology, 2023
Mixed phenotype acute leukemia (MPAL) is characterized by leukemic blasts that express markers of multiple lineages. Compared with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), MPAL is considered to have a poor treatment outcome ...
Mako Ikeda, Wataru Nakahara, Mizuki Asako, Yuka Umeki, Yoshiki Matsuoka, Takuya Terakawa, Hitomi Matsunaga, Yuki Iwasa, Riko Saito, Yuki Iwama, Takahiro Matsui, Kazumasa Oka, Shuji Ueda   +12 more
doaj   +1 more source

Resveratrol given intraperitoneally does not inhibit the growth of high-risk t(4;11) acute lymphoblastic leukemia cells in a NOD/SCID mouse model. [PDF]

, 2011
The efficacy of resveratrol as a preventive agent against the growth of t(4;11) acute lymphoblastic leukemia (ALL) was evaluated in NOD.CB17-Prkdcscid/J mice engrafted with the human t(4;11) ALL SEM cell line.
Ducore, Jonathan M, Keen, Carl L, Newman, John W, Pedersen, Theresa L, Storms, David H, Zunino, Susan J   +5 more
core   +1 more source

Attenuated measles virus controls pediatric acute B-lineage lymphoblastic leukemia in NOD/SCID mice

Haematologica, 2014
Novel therapies are needed for pediatric acute lymphoblastic leukemia resistant to conventional therapy. While emerging data suggest leukemias as possible targets of oncolytic attenuated measles virus, it is unknown whether measles virus can eradicate ...
Nike C. Lühl, Felix Zirngibl, Carmen Dorneburg, Jiwu Wei, Meike Dahlhaus, Thomas F.E. Barth, Lüder H. Meyer, Manon Queudeville, Sarah Eckhoff, Klaus-Michael Debatin, Christian Beltinger   +10 more
doaj   +1 more source

Acute lymphoblastic B‐cell leukemia or CAR‐T cell related skin changes – a relevant diagnostic challenge [PDF]

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Farzan Solimani, Amrei Dilling, K Heisterkamp, Frédérik Damm, Olaf Penack, Christian Oberender, Philipp D. LeCoutre, Martina Rudelius, Kamran Ghoreschi, Alexander Nast   +9 more
openalex   +2 more sources