Results 41 to 50 of about 401,465 (309)

Clinical and Biological Correlates of Neurotoxicity Associated with CAR T-cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia.

Cancer Discovery, 2018
CD19-specific chimeric antigen receptor (CAR) T-cell therapy is highly effective against relapsed or refractory acute lymphoblastic leukemia (ALL), but is hindered by neurotoxicity.
B. Santomasso, Jae H. Park, Darin Salloum, I. Rivière, J. Flynn, E. Mead, E. Halton, Xiuyan Wang, B. Senechal, Terence J. Purdon, J. Cross, Hui Liu, B. Vachha, Xi Chen, L. Deangelis, Daniel H. Li, Y. Bernal, M. Gonen, H. Wendel, M. Sadelain, R. Brentjens   +20 more
semanticscholar   +1 more source

Reported associations between asthma and acute lymphoblastic leukemia: insights from a hybrid simulation study. [PDF]

, 2016
Numerous studies have reported a protective association between asthma and acute lymphoblastic leukemia (ALL), but the causal structure of this association remains unclear.
Arah, Onyebuchi A, Kheifets, Leeka, Olsen, Jorn, Sudan, Madhuri   +3 more
core   +1 more source

CREBBP knockdown enhances RAS/RAF/MEK/ERK signaling in Ras pathway mutated acute lymphoblastic leukemia but does not modulate chemotherapeutic response

Haematologica, 2017
Relapsed acute lymphoblastic leukemia is the most common cause of cancer-related mortality in young people and new therapeutic strategies are needed to improve outcome.
Zach A. Dixon, Lindsay Nicholson, Martin Zeppetzauer, Elizabeth Matheson, Paul Sinclair, Christine J. Harrison, Julie A.E. Irving   +6 more
doaj   +1 more source

Automated Detection of Acute Lymphoblastic Leukemia Subtypes from Microscopic Blood Smear Images using Deep Neural Networks [PDF]

arXiv, 2022
An estimated 300,000 new cases of leukemia are diagnosed each year which is 2.8 percent of all new cancer cases and the prevalence is rising day by day. The most dangerous and deadly type of leukemia is acute lymphoblastic leukemia (ALL), which affects people of all age groups, including children and adults.
arxiv  

The molecular basis of T cell acute lymphoblastic leukemia [PDF]

, 2012
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and ...
Adolfo Ferrando, Bash, Bash, Chen, Condorelli, Dube, Fisch, Hagemeijer, Hebert, Ho, Kelliher, Kikuchi, Larson, Lu, McGuire, McGuire, Nagel, Ntziachristos, Ntziachristos, Ono, Pieter Van Vlierberghe, Royer-Pokora, Rubnitz, van Grotel   +23 more
core   +1 more source

Prognosis of children with mixed phenotype acute leukemia treated on the basis of consistent immunophenotypic criteria

Haematologica, 2010
Background Mixed phenotype acute leukemia (MPAL) represents a diagnostic and therapeutic dilemma. The European Group for the Immunological Classification of Leukemias (EGIL) scoring system unambiguously defines MPAL expressing aberrant lineage markers ...
Ester Mejstrikova, Jana Volejnikova, Eva Fronkova, Katerina Zdrahalova, Tomas Kalina, Jaroslav Sterba, Yahia Jabali, Vladimir Mihal, Bohumir Blazek, Zdena Cerna, Daniela Prochazkova, Jiri Hak, Zuzana Zemanova, Marie Jarosova, Alexandra Oltova, Petr Sedlacek, Jiri Schwarz, Jan Zuna, Jan Trka, Jan Stary, Ondrej Hrusak   +20 more
doaj   +1 more source

THE GENOMIC LANDSCAPE OF PEDIATRIC AND YOUNG ADULT T-LINEAGE ACUTE LYMPHOBLASTIC LEUKEMIA

Nature Genetics, 2017
Genetic alterations that activate NOTCH1 signaling and T cell transcription factors, coupled with inactivation of the INK4/ARF tumor suppressors, are hallmarks of T-lineage acute lymphoblastic leukemia (T-ALL), but detailed genome-wide sequencing of ...
Yu Liu, J. Easton, Ying Shao, J. Maciaszek, Zhaoming Wang, M. Wilkinson, K. McCastlain, Michael N. Edmonson, S. Pounds, Lei Shi, Xin Zhou, Xiaotu Ma, Edgar Sioson, Yongjin Li, Michael C. Rusch, P. Gupta, Deqing Pei, Cheng Cheng, Malcolm A. Smith, J. G. Auvil, D. Gerhard, M. Relling, N. Winick, A. Carroll, N. Heerema, E. Raetz, M. Devidas, C. Willman, R. Harvey, W. Carroll, K. Dunsmore, S. Winter, B. Wood, B. Sorrentino, J. Downing, M. Loh, S. Hunger, Jinghui Zhang, C. Mullighan   +38 more
semanticscholar   +1 more source

Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors

Haematologica, 2014
Three distinct immature T-cell acute lymphoblastic leukemia entities have been described including cases that express an early T-cell precursor immunophenotype or expression profile, immature MEF2C-dysregulated T-cell acute lymphoblastic leukemia cluster
Linda Zuurbier, Alejandro Gutierrez, Charles G. Mullighan, Kirsten Canté-Barrett, A. Olivier Gevaert, Johan de Rooi, Yunlei Li, Willem K. Smits, Jessica G.C.A.M. Buijs-Gladdines, Edwin Sonneveld, A. Thomas Look, Martin Horstmann, Rob Pieters, Jules P.P. Meijerink   +13 more
doaj   +1 more source

Cerebral sinuses thrombosis prior to the diagnosis of acute lymphoblastic leukemia in a child: A case report

SAGE Open Medical Case Reports, 2022
Acute lymphoblastic leukemia is the most common malignancy in children. In children, venous thromboembolism is relatively common. In most cases, venous thromboembolism manifests in patients who are diagnosed with acute lymphoblastic leukemia.
Laila M Sherief, Marwa Zakaria, Basma K Soliman, Naglaa M Kamal, Sultan A Alharthi, Sara AS Abosabie, Mahmoud Abdelazeem   +6 more
doaj   +1 more source

Blinatumomab for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukemia.

Blood, 2018
Approximately 30% to 50% of adults with acute lymphoblastic leukemia (ALL) in hematologic complete remission after multiagent therapy exhibit minimal residual disease (MRD) by reverse transcriptase-polymerase chain reaction or flow cytometry.
N. Gökbuget, H. Dombret, M. Bonifacio, A. Reichle, C. Graux, C. Faul, H. Diedrich, M. Topp, M. Brüggemann, H. Horst, V. Havelange, J. Stieglmaier, Hendrik Wessels, V. Haddad, J. Benjamin, G. Zugmaier, D. Nagorsen, R. Bargou   +17 more
semanticscholar   +1 more source