Results 221 to 230 of about 44,642 (305)

Flow Cytometric and Immunophenotypic Evaluation of Acute Lymphocytic Leukemia in Dog Bone Marrow

, 2001
Douglas J. Weiss
openalex   +1 more source

Semi‐mechanistic population PK/PD model to aid clinical understanding of myelodysplastic syndromes following treatment with Venetoclax and Azacitidine

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.
Abstract Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.
Neha Thakre, Corinna Maier, Jiuhong Zha, Benjamin Engelhardt, Johannes E. Wolff, Sven Mensing   +5 more
wiley   +1 more source

Comparative Analysis of Isavuconazole DDIs With Other Azole Antifungal Drugs and PBPK Model‐Informed Dosing Recommendations for Anticancer Drugs

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Isavuconazole is a broad‐spectrum triazole approved for the treatment of invasive aspergillosis or mucormycosis in adults and children aged ≥ 1 year. Current prescribing information lacks guidance regarding the co‐administration of isavuconazole with anticancer drugs–limited by the availability of clinical drug–drug interaction (DDI) data in ...
Theunis C. Goosen, Xiaofeng Wu, Jian Lin, Narayan Cheruvu, Susan R. Raber, Maria Lavinea Novis de Figueiredo, Manthena V. S. Varma   +6 more
wiley   +1 more source

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia

, 2003
Lanlan Shen, Minoru Toyota, Yutaka Kondo, Toshiro Obata, Sophia Daniel, Sherry Pierce, Kohzoh Imai, Hagop M. Kantarjian, Jean‐Pierre J. Issa, Guillermo Garcia‐Manero   +9 more
openalex   +1 more source

Identification of Clinically Distinct Clusters in Patients With Severe COPD Using Circulating Blood Cell Population Parameters

Respirology, EarlyView.
This study investigated whether blood cell population data, in addition to cell counts, can identify clinically relevant COPD subgroups. Four distinct inflammatory profiles were identified with distinct clinical characteristics. Cell population data have the potential to provide additional insights beyond inflammatory cell counts and improve patient ...
Pauline J. M. Kuks, Jorine E. Hartman, Else A. M. D. ter Haar, L. Joost van Pelt, Dirk‐Jan Slebos, Maarten van den Berge, Simon D. Pouwels   +6 more
wiley   +1 more source

Novel Diffuse Midline Glioma‐on‐Chip Recapitulating Tumor Biophysical Microenvironment to Assess the Heterogeneity of Response to Therapies

Small, EarlyView.
In this work, a DMG‐on‐Chip (DoC) is set up, with a geometry yielding gradients of nutrient and oxygen depletion, to recapitulate this trait of tumor microenvironment‐driven heterogeneity. The biophysical and biochemical characterization of this microsystem via fluorescence microscopy analyses highlights the acidification of the tumor core, along with ...
Lisa Terrassoux, Calypso Hazard, Agathe Laratte, Joanne Balsamelli, Mélanie Arcicasa, Elisa Fong, Léo Baland, Fabrice Soncin, Giovanni Cappello, Claude‐Alain Maurage, Sebastien Janel, Antony Bazir, Fabrizio Cleri, Anthony Treizebre, Eric Lartigau, Yousr Rekik, Samuel Meignan, Alessandro Furlan   +17 more
wiley   +1 more source

Bioengineered Extracellular Vesicles in Emerging Cancer Vaccine Platforms

Small Science, EarlyView.
This review highlights recent advances in engineering extracellular vesicles (EVs) as next‐generation cancer vaccines. It outlines their biological roles and antigen‐presenting capacity, explores key strategies for antigen loading and delivery optimization, and summarizes preclinical and clinical applications using EVs from diverse immune and tumor ...
Wonkyung Ahn, Yeram Lee, Gi‐Hoon Nam, Jae Bem You, Eun Jung Lee   +4 more
wiley   +1 more source

40 Long term comparison of relapse and overall survival in patients with chronic myeloid leukemia (CML) and acute lymphocytic leukemia (all) treated with unrelated or related donor allogeneic marrow/stem cell transplantation

, 2003
S.A. Al-Sukbun, Esteban Abella, Roy D. Baynes, Chatchada Karanes, RD Dansey   +4 more
openalex   +1 more source

Silibinin‐driven microbial and metabolic reprogramming restores CD4+ T cell immunity in HIV immunological nonresponders

VIEW, EarlyView.
Despite efficacious antiretroviral therapy, 10%–40% of HIV‐infected individuals exhibit inadequate immune reconstitution due to persistent inflammatory activation and NAD+ metabolic dysregulation—a critical cofactor in cellular bioenergetics. We administered silibinin to 53 HIV immunological non‐responders and elucidated its mechanism through selective
Wenli Liu, Minghui An, Qi Wang, Yuxin Shang, Shuyao Zang, Haibo Ding, Shuai Fu, Yun Liu, Xue Dong, Xiao Yang, Jinna Dai, Xiaoxu Han, Yingchun Xu, Hong Shang   +13 more
wiley   +1 more source