Results 241 to 250 of about 351,966 (398)

Common nonmutational NOTCH1 activation in chronic lymphocytic leukemia

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2017
G. Fabbri   +12 more
semanticscholar   +1 more source

Loss‐of‐Function Variants in CPT1C: No Support for a Causal Role in Hereditary Spastic Paraplegia

open access: yesMovement Disorders, EarlyView.
Abstract Background Hereditary spastic paraplegias (HSPs) are neurodegenerative disorders characterized by lower‐limb spasticity. Pathogenic variants in CPT1C have been implicated in HSP. Objective The objective of this study was to assess whether CPT1C loss‐of‐function (LOF) variants are causally associated with HSP.
Rui Zhu   +17 more
wiley   +1 more source

Extramedullary Involvement of the Ascending Colon in Relapsing Acute Lymphocytic Leukemia: A Case Report. [PDF]

open access: yesSaudi J Med Med Sci, 2022
Ifthikar Z   +5 more
europepmc   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi   +2 more
wiley   +1 more source

Disparities in Acute Lymphocytic Leukemia Outcomes Among Young Adults. [PDF]

open access: yesJ Hematol
McKinnell Z   +7 more
europepmc   +1 more source

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