Results 241 to 250 of about 44,642 (305)

The epidemiological landscape of bloodstream infections in children undergoing chemotherapy or haematopoietic cell transplantation: A retrospective study by Infectious Diseases Working Group of Italian Association of Pediatric Hematology and Oncology (AIEOP)

British Journal of Haematology, EarlyView.
Summary Understanding bloodstream infection (BSI) epidemiology is crucial for optimizing antibiotic therapy in paediatric haematology–oncology patients undergoing chemotherapy or haematopoietic cell transplantation (HCT). However, updated paediatric data remain scarce.
Francesco Baccelli, Francesca Compagno, Gloria Tridello, Francesco Delle Cave, Daniele Zama, Riccardo Masetti, Maria Grazia Petris, Lorenzo Chiusaroli, Manuela Spadea, Francesca Trevisan, Antonella Colombini, Samantha Conci, Cristina Meazza, Paola Muggeo, Maria Vittoria Micheletti, Alessia Pancaldi, Rosamaria Mura, Daniela Onofrillo, Raffaella De Santis, Milena La Spina, Elio Castagnola, Katia Perruccio, Angelica Barone, Nagua Giurici, Angelamaria Petrone, Federico Mercolini, Simona Rinieri, Simone Cesaro, Francesca Carraro7, Annalisa Tondo9, Laura Rachele Bettini10, Elena Pletto2, Olga Nigro11, Roberta Martino12, Eva Parolo13, Giovanni Palazzi12   +35 more
wiley   +1 more source

UK recommendations for chimerism testing and monitoring following allogeneic haematopoietic stem cell transplantation (HSCT): Best practice consensus guidelines from the British Society for Blood and Marrow Transplant and Cellular Therapies (BSBMTCT), NHS England Genomic Laboratory Hub (GLH) Haematological Malignancies Working Group, UK Cancer Genetics Group (UKCGG) and the UK National External Quality Assessment Service for Leucocyte Immunophenotyping (UK NEQAS LI)

British Journal of Haematology, EarlyView.
Summary In allogeneic haematopoietic stem cell transplantation (HSCT), important clinical decisions depend upon assessment of chimerism, including immunosuppressant dosing and donor lymphocyte infusions (DLI), which in turn can have major impacts on disease control, graft‐versus‐host disease (GVHD), immunity and ultimately patient survival.
Andrew Clark, Hazel Clouston, Kanchan Rao, Najeem Folarin, Josu De la Fuente, Angela Hamblin, Eduardo Olavarria, Debbie Richardson, Polly Talley, Victoria Potter, Justin Loke, Terri McVeigh, John Snowden   +12 more
wiley   +1 more source

Has early mortality following single‐unit unrelated cord blood transplantation improved in recent years? A nationwide registry data analysis from 2003 to 2022 in Japan

British Journal of Haematology, EarlyView.
The 100‐day non‐relapse mortality after single‐unit cord blood transplantation significantly declined from 19.6% (2003–2007) to 9.5% (2018–2022), while the 3‐year overall survival improved from 38.8% to 54.4%. Haematopoietic recovery rates improved steadily, with neutrophil engraftment reaching 89.6% and platelet engraftment 78.0% in the most recent ...
Takaaki Konuma, Junya Kanda, Naoyuki Uchida, Masatsugu Tanaka, Fumihiko Kimura, Hideki Nakasone, Yasufumi Uehara, Masahito Tokunaga, Masako Toyosaki, Shigesaburo Miyakoshi, Noriko Doki, Kazuya Ishiwata, Hikaru Kobayashi, Yasushi Onishi, Yasuji Kozai, Koji Kato, Fumihiko Ishimaru, Takahiro Fukuda, Yoshiko Atsuta, Satoshi Takahashi   +19 more
wiley   +1 more source

Outcomes after a second allogeneic haematopoietic stem cell transplant for relapsed paediatric acute myeloid leukaemia improved over time: A study from the EBMT Paediatric Diseases Working Party

British Journal of Haematology, EarlyView.
We retrospectively evaluated outcomes after a second haematopoietic stem cell transplantation (HSCT) performed between 2000 and 2022 for relapsed acute myeloid leukaemia in 345 children. We found that leukaemia‐free survival, overall survival, graft‐versus‐host disease (GVHD)/relapse‐free survival (GRFS) and relapse incidence improved over time, while ...
Nimrod Buchbinder, Victor Michel, Arnaud Dalissier, Katharina Kleinschmidt, Franco Locatelli, Alexei Maschan, Robert Wynn, Franca Fagioli, Marco Zecca, Charlotte Jubert, Birgitta Versluys, Petr Sedlacek, Ludmila Zubarovskaya, Marta Gonzalez Vicent, Alessandra Biffi, Gérard Michel, Oana Mirci‐Danicar, Wolfgang Holter, Marc Ansari, Jacques‐Emmanuel Galimard, Pascale Schneider, Mouad Abouqateb, Krzysztof Kałwak   +22 more
wiley   +1 more source

Prognostic impact of valemetostat in relapsed/refractory adult T‐cell leukaemia‐lymphoma

British Journal of Haematology, EarlyView.
Summary The prognosis for patients with relapsed/refractory (R/R) adult T‐cell leukaemia‐lymphoma (ATL) remains dismal. Recently, valemetostat, a dual inhibitor for enhancer of zeste homologue (EZH) 1 and 2, was approved in Japan for R/R aggressive ATL. However, there is no real‐world data on the efficacy and prognosis of valemetostat.
Takafumi Shichijo, Hiro Tatetsu, Yusuke Higuchi, Toshikazu Miyakawa, Kisato Nosaka, Takahisa Nakamura, Shinya Endo, Asami Yamada, Atsushi Wada, Yuki Okamoto, Toshiro Kawakita, Hitoshi Suzushima, Masao Matsuoka, Jun‐ichirou Yasunaga   +13 more
wiley   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

TRPA1 ion channel activation context‐dependently regulates gene expression in normal and psoriatic human skin

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Psoriasis is a chronic, relapsing, immune‐mediated inflammatory skin disease. The transient receptor potential ankyrin 1 (TRPA1) ion channel plays a protective role in the formation of psoriasiform skin reactions. Here, we investigated the pharmacological activation and blockade of TRPA1 in human skin (patho)physiology ...
Ágnes Kemény, Szabina Horváth, Júlia Szebényi, Péter Oláh, Viktória Németh, Péter Urbán, József Kun, Attila Gyenesei, Areej Jaber, Erika Pintér, Rolland Gyulai   +10 more
wiley   +1 more source

Acute lymphocytic leukemia in children

Cancer, 1975
An overview is presented of the improvements in the prognosis of acute lymphocytic leukemia due to combined modality therapy. With the best available regimens, approximately 50% of these children have remained leukemia-free for 5 years or more. Because of these results, there is growing concern for the quality of survival and for the side effects of ...
H. Omar Hustu, Rhomes J. A. Aur, M. S. Verzosa, Joseph V. Simone   +3 more
openaire   +4 more sources

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Acute lymphocytic leukemia

Hématologie, 2014
Les leucemies aigues lymphoblastiques (LAL) sont des proliferations malignes de precurseurs lymphoides anormaux bloques a un stade precoce de differenciation. Les LAL de l’enfant et de l’adulte different par leurs caracteristiques et leurs pronostics. L’identification de nouveaux mecanismes d’oncogenese et l’evaluation de la reponse par quantification ...
Martin Gauthier, Diane Lara
openaire   +2 more sources

Survival in Acute Lymphocytic Leukemia

JAMA: The Journal of the American Medical Association, 1973
To the Editor.— The statement by Hinkes and Plotkin (223:1490, 1973) that "perhaps 0.1% to 1% of patients with acute leukemia survive five or more years" gives an erroneously bleak outlook. No longer is the fiveyear survivor a rarity. Recently, Ingelfinger quoted the Director of the National Cancer Institute who said that "50 per cent of children with
Hans W. Grünwald, Fred Rosner
openaire   +3 more sources