Results 261 to 270 of about 87,634 (337)

Semi‐mechanistic population PK/PD model to aid clinical understanding of myelodysplastic syndromes following treatment with Venetoclax and Azacitidine

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.
Abstract Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.
Neha Thakre   +5 more
wiley   +1 more source

Plasmonic Mesoporous Gold‐Based SERS Biosensor for Ovarian Cancer‐Derived Extracellular Vesicles

open access: yesSmall, EarlyView.
The nanoengineered mesoporous gold (mAu)‐based SERS platform enables rapid, sensitive detection of PLAP‐positive extracellular vesicles (EVs) in ovarian cancer (OC), with detection limits as low as 100 EVs mL−1. Achieving over 80% sensitivity and 98% specificity in clinical samples, this cost‐effective, non‐invasive tool shows promise for early cancer ...
Javeria Bashir   +16 more
wiley   +1 more source

CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapy

open access: yesVIEW, EarlyView.
Abstract Immuno‐oncology represents an emerging field that has significantly transformed tumor therapeutics, with immune cells serving as the cellular foundations of cancer immunotherapy. Due to its high efficiency and sensitivity, CRISPR/Cas9 genome editing is a highly promising technique for precise and rapid gene modification.
Yuhui Ma   +6 more
wiley   +1 more source

Single‐cell spatial transcriptomic sequencing and machine learning models uncover molecular mechanisms and diagnostic biomarkers of Peyronie's disease formation in rats

open access: yesVIEW, EarlyView.
Peyronie's disease (PD) is a common male reproductive system disorder. The exact etiology of PD remains unclear. This study aimed to investigate molecular and cellular changes in PD using single‐cell spatial transcriptomics. Abstract Peyronie's disease (PD), commonly known as penile induration, is a prevalent male reproductive system disorder with ...
Keyuan Lou   +6 more
wiley   +1 more source

Development of an In Vivo Bone Tungsten K‐X‐Ray Fluorescence Detection System

open access: yesX-Ray Spectrometry, EarlyView.
ABSTRACT The versatility of tungsten (W) in electronics as well as in industrial and military applications has established it as one of the metals more present in our daily lives. Recent studies have highlighted its potential in the healthcare sector, including using sodium tungstate for anti‐diabetic treatment and W nanoparticles to enhance radiation ...
Sajed Mcheik   +2 more
wiley   +1 more source

Maximum Standard Uptake Value of Pre‐Therapeutic 18F‐Fluorodeoxyglucose Positron Emission Tomography Predicts Outcomes in Indolent Adult T‐Cell Leukemia/Lymphoma Patients With Cutaneous Involvement

open access: yesThe Journal of Dermatology, EarlyView.
ABSTRACT The prognostic utility of 18F‐fluorodeoxyglucose positron emission tomography (FDG‐PET) in adult T‐cell leukemia/lymphoma (ATLL) remains unclear, particularly in patients with indolent subtypes and cutaneous involvement. This study aimed to evaluate the usefulness of FDG‐PET in predicting clinical outcomes in patients with indolent ATLL ...
Kyoko Nogami   +6 more
wiley   +1 more source

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