Results 41 to 50 of about 1,599,857 (245)

New Therapeutic Approaches for Acute Myeloid Leukaemia [PDF]

, 2021
Acute myeloid leukaemia (AML) is a genetically heterogeneous haematopoietic neoplasm characterised by the accumulation of transformed immature blood progenitors in bone marrow.
Ruth M Risueno, Jose M Carbo, Josep M Cornet-Masana, Laia Cuesta-Casanovas   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Acute leukaemoid reaction following cardiac surgery

Journal of Cardiothoracic Surgery, 2007
Chronic myelomonocytic leukaemia is an atypical myeloproliferative disorder with a natural history of progression to acute myeloid leukaemia, a complex and poorly understood response by the bone marrow to stress.
Webb Stephen T, Mussa Shafi, Ali Ayyaz, Drury Nigel E, Rege Kanchan P, Wallwork John   +5 more
doaj   +1 more source

Prevalence And Diagnosis of Acute Leukaemia - Experience in 50 Cases in AFIP

Haematology Journal of Bangladesh, 2022
Background: Haematological malignancies covers a wide range of diseases ranging from acute leukaemia to different type of lymphoproliferative disorders among which acute leukemia is a major concern all over the world.
Md. Nurun Nabi, Mosammath Khadiza Mamdu, Ayesha Siddika, Md. Abdul Aziz   +3 more
doaj   +1 more source

Feasibility of azacitidine added to standard chemotherapy in older patients with acute myeloid leukemia - a randomised SAL pilot study [PDF]

, 2012
INTRODUCTION: Older patients with acute myeloid leukemia (AML) experience short survival despite intensive chemotherapy. Azacitidine has promising activity in patients with low proliferating AML.
Ulrich Dührsen, Anja Koschmieder (106749), Matthias Stelljes, Christian Thiede (106768), Carsten Müller-Tidow, Nicola Tidow (106758), Noppeney, Richard, Utz Krug, Gerhard Ehninger, Daniela Schwammbach (106754), Steffen Koschmieder, Nicola Tidow, Wolfgang E Berdel, Markus Schaich (106764), Stelljes, Matthias, Matthias Stelljes (106772), Utz Krug (106744), Carsten Müller-Tidow (105305), Krug, Utz, Tidow, Nicola, Bug, Gesine, Schaich, Markus, Björn Steffen, Richard Noppeney (106769), Gerss, Joachim, Christian Thiede, Joachim Gerss, Schwammbach, Daniela, Thomas Büchner, Björn Steffen (106759), Büchner, Thomas, Ulrich Dührsen (106782), Anja Koschmieder, Christoph Röllig, Steffen, Björn, Markus Schaich, Steffen Koschmieder (106779), Thomas Büchner (106775), Hubert Serve, Koschmieder, Steffen, Christian H. Brandts (106762), Ehninger, Gerhard, Brandts, Christian Hubertus, Berdel, Wolfgang E., Joachim Gerss (106757), Gerhard Ehninger (106788), Dührsen, Ulrich, Wolfgang E. Berdel (106792), Richard Noppeney, Gesine Bug (106760), Serve, Hubert, Müller-Tidow, Carsten, Daniela Schwammbach, Christian H Brandts, Hubert Serve (106786), Thiede, Christian, Gesine Bug, Koschmieder, Anja, Röllig, Christoph, Christoph Röllig (106766), Koschmieder Steffen, Ehninger, G. (Gerhard), Schaich, M. (Markus), Tidow Nicola, Gerß, J. (Joachim), Müller-Tidow, C. (Carsten), Steffen Björn, Röllig, C. (Christoph), Thiede Christian, Dührsen, U. (Ulrich), Bug Gesine, Brandts, C.H. (Christian), Stelljes Matthias, Thiede, C. (Christian), Brandts Christian H., Noppeney, R. (Richard), Büchner, T. (Thomas), Schaich Markus, Tidow, N. (Nicola), Schwammbach, D. (Daniela), Röllig Christoph, Steffen, B. (Björn), Koschmieder Anja, Serve, H. (Hubert), Koschmieder, A. (Anja), Noppeney Richard, Bug, G. (Gesine), Krug Utz, Dührsen Ulrich, Stelljes, M. (Matthias), Berdel, W.E. (Wolfgang), Büchner Thomas, Schwammbach Daniela, Serve Hubert, Krug, U. (Utz), Berdel Wolfgang E., Ehninger Gerhard, Koschmieder, S. (Steffen), Gerss Joachim, Müller-Tidow Carsten   +99 more
core   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Ophthalmic Manifestations In Patients of Acute Leukaemia Presenting to A Tertiary Care Centre In Western Rajasthan

Delhi Journal of Ophthalmology, 2018
Purpose:- To determine the prevalence and pattern of ophthalmic manifestations in patients of Acute Myeloid Leukemia (AML) and Acute Lymphoid Leukemia (ALL) presenting to a tertiary care centre in Western Rajasthan.
Shilpi Kochar, Yamini Singhal, Jaishree Murli Manohar, Kalpana Jain   +3 more
doaj   +1 more source

Engineered model of t(7;12)(q36;p13) AML recapitulates patient-specific features and gene expression profiles

Oncogenesis, 2022
Acute myeloid leukaemia carrying the translocation t(7;12)(q36;p13) is an adverse-risk leukaemia uniquely observed in infants. Despite constituting up to 30% of cases in under 2-year-olds, it remains poorly understood.
Denise Ragusa, Ylenia Cicirò, Concetta Federico, Salvatore Saccone, Francesca Bruno, Reza Saeedi, Cristina Sisu, Cristina Pina, Arturo Sala, Sabrina Tosi   +9 more
doaj   +1 more source

Investigations of FLT3 internal tandem duplications in patients with acute myeloid leukaemia. [PDF]

, 2006
In acute myeloid leukaemia (AML), further prognostic determinants are required in addition to cytogenetics to predict patients at increased risk of relapse. Recent studies have indicated an internal tandem duplication (ITD) in the FLT3 gene may adversely
Kottaridis, P.D., Kottaridis, Panagiotis
core  

FT-infrared spectroscopic studies of lymphoma, lymphoid and myeloid leukaemia cell lines [PDF]

, 2007
This paper presents a novel method to characterise spectral differences that distinguish leukaemia and lymphoma cell lines. This is based on objective spectral measurements of major cellular biochemical constituents and multivariate spectral ...
Babrah, Jaspreet, McCarthy, Keith P., Lush, Richard, Bessant, Conrad M., Rye, Adam D., Stone, Nicholas, Jaspreet Babrah, Adam D. Rye, Nicholas Stone, Keith P. McCarthy, Richard Lush, Conrad Bessant   +11 more
core   +1 more source