Results 91 to 100 of about 442,026 (299)

Flotetuzumab as Salvage Immunotherapy for Refractory Acute Myeloid Leukemia.

Blood, 2020
Despite recent advancements, approximately 50% of patients with acute myeloid leukemia (AML) do not respond to induction therapy (primary induction failure, PIF) or relapse after
Geoffrey L. Uy, Ibrahim Aldoss, M. Foster, P. Sayre, M. Wieduwilt, A. Advani, J. Godwin, M. Arellano, K. Sweet, A. Emadi, F. Ravandi, H. Erba, M. Byrne, L. Michaelis, M. Topp, N. Vey, F. Ciceri, M. Carrabba, S. Paolini, G. Huls, M. Jongen‐Lavrencic, M. Wermke, P. Chevallier, E. Gyan, C. Récher, P. Stiff, K. Pettit, B. Löwenberg, S. Church, Erica Anderson, J. Vadakekolathu, Marianne T Santaguida, M. Rettig, J. Muth, Teia Curtis, E. Fehr, Kuo Guo, Jian Zhao, Ouiam Bakkacha, Kenneth Jacobs, K. Tran, P. Kaminker, M. Kostova, E. Bonvini, R. Walter, J. Davidson-Moncada, S. Rutella, J. Dipersio   +47 more
semanticscholar   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Epigenetic-based differentiation therapy for Acute Myeloid Leukemia

Nature Communications
Despite the development of novel therapies for acute myeloid leukemia, outcomes remain poor for most patients, and therapeutic improvements are an urgent unmet need. Although treatment regimens promoting differentiation have succeeded in the treatment of
Edurne San José-Enériz, Naroa Gimenez-Camino, Obdulia Rabal, Leire Garate, Estibaliz Miranda, Nahia Gómez-Echarte, Fernando García, Stella Charalampopoulou, Elena Sáez, Amaia Vilas-Zornoza, Patxi San Martín-Uriz, Luis V. Valcárcel, Naroa Barrena, Diego Alignani, Luis Esteban Tamariz-Amador, Ana Pérez-Ruiz, Sebastian Hilscher, Mike Schutkowski, Ana Alfonso-Pierola, Nicolás Martinez-Calle, María José Larrayoz, Bruno Paiva, María José Calasanz, Javier Muñoz, Marta Isasa, José Ignacio Martin-Subero, Antonio Pineda-Lucena, Julen Oyarzabal, Xabier Agirre, Felipe Prósper   +29 more
doaj   +1 more source

t(6;9)(p22;q34)/DEK-NUP214-rearranged pediatric myeloid leukemia: an international study of 62 patients

Haematologica, 2014
Acute myeloid leukemia with t(6;9)(p22;q34) is listed as a distinct entity in the 2008 World Health Organization classification, but little is known about the clinical implications of t(6;9)-positive myeloid leukemia in children.
Julie Damgaard Sandahl, Eva A. Coenen, Erik Forestier, Jochen Harbott, Bertil Johansson, Gitte Kerndrup, Souichi Adachi, Anne Auvrignon, H. Berna Beverloo, Jean-Michel Cayuela, Lucy Chilton, Maarten Fornerod, Valérie de Haas, Christine J. Harrison, Hiroto Inaba, Gertjan J.L. Kaspers, Der-Cherng Liang, Franco Locatelli, Riccardo Masetti, Christine Perot, Susana C. Raimondi, Katarina Reinhardt, Daisuke Tomizawa, Nils von Neuhoff, Marco Zecca, C. Michel Zwaan, Marry M. van den Heuvel-Eibrink, Henrik Hasle   +27 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

The chromatin-remodeling factor CHD4 is required for maintenance of childhood acute myeloid leukemia

Haematologica, 2018
Epigenetic alterations contribute to leukemogenesis in childhood acute myeloid leukemia and therefore are of interest for potential therapeutic strategies.
Yaser Heshmati, Gözde Türköz, Aditya Harisankar, Shabnam Kharazi, Johan Boström, Esmat Kamali Dolatabadi, Aleksandra Krstic, David Chang, Robert Månsson, Mikael Altun, Hong Qian, Julian Walfridsson   +11 more
doaj   +1 more source

The origin and evolution of mutations in Acute Myeloid Leukemia

Cell, 2012
Summary Most mutations in cancer genomes are thought to be acquired after the initiating event, which may cause genomic instability, driving clonal evolution.
J. Welch, T. Ley, D. Link, Christopher A. Miller, D. Larson, D. Koboldt, L. Wartman, T. Lamprecht, Fulu Liu, Jun Xia, Cyriac Kandoth, R. Fulton, M. McLellan, D. Dooling, J. Wallis, Ken Chen, C. Harris, Heather K. Schmidt, Joelle M. Kalicki-Veizer, Charles Lu, Qunyuan Zhang, Ling Lin, M. O'Laughlin, Joshua F. McMichael, K. D. Delehaunty, L. Fulton, V. Magrini, S. McGrath, Ryan T. Demeter, T. Vickery, J. Hundal, L. Cook, Gary W. Swift, Jerry P. Reed, Patricia A. Alldredge, T. Wylie, Jason R. Walker, M. Watson, S. Heath, W. Shannon, Nobish Varghese, Rakesh Nagarajan, J. Payton, J. Baty, S. Kulkarni, J. Klco, M. Tomasson, P. Westervelt, M. Walter, T. Graubert, J. Dipersio, L. Ding, E. Mardis, R. Wilson   +53 more
semanticscholar   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Age and acute myeloid leukemia

Blood, 2006
We conducted a retrospective analysis of 968 adults with acute myeloid leukemia (AML) on 5 recent Southwest Oncology Group trials to understand how the nature of AML changes with age. Older study patients with AML presented with poorer performance status, lower white blood cell counts, and a lower percentage of marrow blasts.
Frederick R, Appelbaum, Holly, Gundacker, David R, Head, Marilyn L, Slovak, Cheryl L, Willman, John E, Godwin, Jeanne E, Anderson, Stephen H, Petersdorf   +7 more
openaire   +3 more sources

Acute Myeloid Leukemia in Adults [PDF]

, 2018
AML is a malignancy of hematopoietic immature precursors (myeloblasts) that accumulate in the BM at the expense of their normal counterparts.
Versluis, Jurjen, Cornelissen, Jan J., Craddock, Charles, Sanz, Miguel A., Canaani, Jonathan, Nagler, Arnon   +5 more
openaire   +2 more sources