Results 91 to 100 of about 49,720 (263)

The chromatin-remodeling factor CHD4 is required for maintenance of childhood acute myeloid leukemia

Haematologica, 2018
Epigenetic alterations contribute to leukemogenesis in childhood acute myeloid leukemia and therefore are of interest for potential therapeutic strategies.
Yaser Heshmati, Gözde Türköz, Aditya Harisankar, Shabnam Kharazi, Johan Boström, Esmat Kamali Dolatabadi, Aleksandra Krstic, David Chang, Robert Månsson, Mikael Altun, Hong Qian, Julian Walfridsson   +11 more
doaj   +1 more source

Reciprocal t(9;22) ABL/BCR fusion proteins: leukemogenic potential and effects on B cell commitment

, 2009
Background: t(9;22) is a balanced translocation, and the chromosome 22 breakpoints (Philadelphia chromosome – Ph+) determine formation of different fusion genes that are associated with either Ph+ acute lymphatic leukemia (Ph+ ALL) or chronic myeloid ...
Xiaomin Zheng, Malcolm A S Moore, Martin Ruthardt, Ruthardt, Martin, Oancea, Claudia, Claudia Oancea, Malcolm A. S. Moore, Reinhard Henschler, Henschler, Reinhard, Moore, Malcolm A. S., Zheng, Xiaomin   +10 more
core   +1 more source

Influence of Cytokines and Autologous Lymphokine-Activated Killer Cells on Leukemic Bone Marrow Cells and Colonies in AML [PDF]

, 2001
We have already shown that cytokine cocktails (IL-1 beta, IL-3, IL-6, SCF, GM-CSF) and/or lymphokine-activated killer (LAK) cells can reduce the amounts of clonal, CD34-positive mononuclear bone marrow cells (BM-MNC) in acute myeloid leukemia (AML).
Gerhartz, Helmut Heinrich, Schmetzer, Helga Maria, Braun, Susanne Walburg   +2 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Epigenetic-based differentiation therapy for Acute Myeloid Leukemia

Nature Communications
Despite the development of novel therapies for acute myeloid leukemia, outcomes remain poor for most patients, and therapeutic improvements are an urgent unmet need. Although treatment regimens promoting differentiation have succeeded in the treatment of
Edurne San José-Enériz, Naroa Gimenez-Camino, Obdulia Rabal, Leire Garate, Estibaliz Miranda, Nahia Gómez-Echarte, Fernando García, Stella Charalampopoulou, Elena Sáez, Amaia Vilas-Zornoza, Patxi San Martín-Uriz, Luis V. Valcárcel, Naroa Barrena, Diego Alignani, Luis Esteban Tamariz-Amador, Ana Pérez-Ruiz, Sebastian Hilscher, Mike Schutkowski, Ana Alfonso-Pierola, Nicolás Martinez-Calle, María José Larrayoz, Bruno Paiva, María José Calasanz, Javier Muñoz, Marta Isasa, José Ignacio Martin-Subero, Antonio Pineda-Lucena, Julen Oyarzabal, Xabier Agirre, Felipe Prósper   +29 more
doaj   +1 more source

Comparative analysis of blood lymphocytes of patients with acute and chronic myeloid leukemia by surface and intracellular α1-acid glycoprotein and fibronectin

Біологічні студії, 2014
The exposition of α1-acid glycoprotein and fibronectin on the surface and inside the lymphocytes of healthy donors and hematological patients with acute and chronic myeloid leukemia were studied.
G. S. Маslak
doaj   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

FLT3 mutations in Early T-Cell Precursor ALL characterize a stem cell like leukemia and imply the clinical use of tyrosine kinase inhibitors

, 2013
Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) has been identified as high-risk subgroup of acute T-lymphoblastic leukemia (T-ALL) with a high rate of FLT3-mutations in adults.
Hartmut Döhner (276603), Hofmann, Wolf-Karsten, Christian Brandts, Ulrich Dührsen, Eckhard Thiel (66496), Mochmann, Liliana H., Burmeister, Thomas, Lars Fransecky, Neumann, Martin, Döhner, Hartmut, Eckhard Thiel, Nicola Gökbuget, Claudia D Baldus, Martin Griesshammer (276602), Rainer Haas (81562), Sartangi, Nasrin Farhadi, Martin Neumann (276593), Gerhard Ehninger, Schwartz, Stefan, Dieter Hoelzer, Stefan Schwartz (276600), Nicola Gökbuget (276599), Olga Blau, Isabelle Bartram, Bartram, Isabelle, Thiel, Eckhard, Liliana H Mochmann, Wolf-Karsten Hofmann, Thomas Burmeister, Martin Neumann, Martin Griesshammer, Sandra Heesch (276598), Heesch, Sandra, Haas, Rainer, Rainer Haas, Schlee, Cornelia, Fransecky, Lars, Ulrich Dührsen (106782), Griesshammer, Martin, Christian Brandts (276601), Lars Fransecky (276595), Ebru Coskun, Claudia D. Baldus (66494), Isabelle Bartram (276596), Wolf-Karsten Hofmann (66497), Ehninger, Gerhard, Brandts, Christian Hubertus, Baldus, Claudia, Gerhard Ehninger (106788), Dührsen, Ulrich, Hoelzer, Dieter, Cornelia Schlee, Dieter Hoelzer (551), Cornelia Schlee (105296), Ebru Coskun (276594), Gökbuget, Nicola, Sandra Heesch, Liliana H. Mochmann (105294), Hartmut Döhner, Nasrin Farhadi Sartangi, Nasrin Farhadi Sartangi (276597), Thomas Burmeister (276604), Stefan Schwartz, Coskun, Ebru, Olga Blau (276605), Blau, Olga   +65 more
core   +1 more source

A novel three-colour fluorescence in situ hybridization approach for the detection of t(7;12)(q36;p13) in acute myeloid leukaemia reveals new cryptic three way translocation t(7;12;16) [PDF]

, 2013
© 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).The t(7;12)(q36;p13 ...
Vetter, M, Sabrina Tosi, Plekhanova, O, Fleischman, E, Grigory Tsaur, Tsaur, G, Harbott, J, Sokova, O, Jochen Harbott, Tosi, S, Elena Fleischman, Olga Sokova, Naiel, A, Michael Vetter, Olga Plekhanova, Abdulbasit Naiel   +15 more
core   +1 more source