Results 71 to 80 of about 49,720 (263)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Prenatal origin of childhood AML occurs less frequently than in childhood ALL [PDF]

, 2006
Background While there is enough convincing evidence in childhood acute lymphoblastic leukemia (ALL), the data on the pre-natal origin in childhood acute myeloid leukemia (AML) are less comprehensive.
Meyer, Claus, Schneider, Bjoern, Votava, Felix, Madzo Jozef, Claus Meyer, Jan Trka, Zuna, Jan, Meyer Claus, Marschalek Rolf, Schneider Bjoern, Votava Felix, Tatiana Burjanivova, Burjanivova Tatiana, Zuna Jan, Katerina Muzikova, Muzikova, Katerina, Jan Zuna, Madzo, Jozef, Muzikova Katerina, Burjanivova, Tatiana, Stary Jan, Tatiana Burjanivova, Trka Jan, Marschalek, Rolf (Prof. Dr.), Bjoern Schneider, Rolf Marschalek, Jozef Madzo, Jan Stary, Felix Votava, Trka, Jan, Rolf Marschalek, Stary, Jan   +31 more
core   +1 more source

Genomics of Acute Myeloid Leukemia [PDF]

The Cancer Journal, 2011
The acute myeloid leukemia (AML) genome has been the subject of intensive research over the past 4 decades. New technologies, enabling characterization of the AML genome at increased resolution, have revealed deeper layers of complexity that have provided insights into the biological basis of this disease, nominated targets for therapy, and identified ...
Timothy A, Graubert, Elaine R, Mardis
openaire   +2 more sources

Nanobody‐Conjugated Theranostic Prodrug Targeting αvβ3 Integrin Enables Precision Cancer Therapy With Real‐Time Imaging

Advanced Healthcare Materials, EarlyView.
The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.
Sanu Karan, Hyunseung Lee, Rema Naskar, Mi Young Cho, Hye Sun Park, Eun Hee Han, Soumyadip Hore, Sun Hee Cho, Truc Ngoc Kim Lam, Taewoong Son, Tae Jung Park, Inkyu Hwang, Jonathan L. Sessler, Kwan Soo Hong   +13 more
wiley   +1 more source

Association of Glutathione S-transferase Genes (M1 and T1) with the Risk of Acute Myeloid Leukemia in a Moroccan Population

Middle East Journal of Cancer, 2017
Background: Acute myeloid leukemia, as most cancers, results from exposure to carcinogens and an impaired inherited individual capacity to eliminate xenobiotics. The present case-control study measures the relationship between glutathione S-transferase
Ait Boujmia Oum Kaltoum, Nadifi Sellama, Dehbi Hind, Kassogue Yaya, Lamchahab Mouna, Quessar Asma   +5 more
doaj  

Bone marrow endothelial cell-derived interleukin-4 contributes to thrombocytopenia in acute myeloid leukemia

Haematologica, 2019
Normal hematopoiesis can be disrupted by the leukemic bone marrow microenvironment, which leads to cytopenia-associated symptoms including anemia, hemorrhage and infection.
Ai Gao, Yuemin Gong, Caiying Zhu, Wanzhu Yang, Qing Li, Mei Zhao, Shihui Ma, Jianyong Li, Sha Hao, Hui Cheng, Tao Cheng   +10 more
doaj   +1 more source

Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia

, 2005
The prognostic significance of FLT3 mutations in acute promyelocytic leukemia (APL) is not firmly established and is of particular interest given the opportunities for targeted therapies using FLT3 inhibitors.
Gilkes, Amanda F., Ellen Solomon, Linch, D C, Gale, Rosmary E., Burnett, Alan Kenneth, Gale, RE, David C. Linch, Pizzey, AR, Elizabeth Nugent, Keith Wheatley, Grimwade, D., Grimwade, D, Solomon, E, Pizzey, A R, Solomon, Ellen, Kenneth I. Mills, Swirsky, D, Pizzey, A.R., Burnett, A K, Alan K. Burnett, Hills, Robert Kerrin, Swirsky, David, Kottaridis, Panagiotis D., Grimwade, David, Linch, David C., ?, ?, Hills, R., David Swirsky, Gale, R E, Gilkes, A F, Kottaridis, PD, Solomon, E., Robert Hills, Linch, D.C., Arnold R. Pizzey, Nugent, E., Rosemary E. Gale, Mills, KI, Nugent, Elizabeth, Gale, R.E., Swirsky, D., Hills, Robert, Hills, R, NCRI Adult Leukaemia Working Party, David Grimwade, Kottaridis, P D, Linch, DC, Wheatley, K., Amanda F. Gilkes, Wheatley, Keith, Gilkes, AF, Nugent, E, Panagiotis D. Kottaridis, Mills, K I, Mills, Ken; id_orcid, Kottaridis, P.D., Burnett, AK, Burnett, A.K., Mills, Kenneth I., Gilkes, A.F., Wheatley, K, Pizzey, Arnold R.   +61 more
core   +1 more source

Age and acute myeloid leukemia

Blood, 2006
We conducted a retrospective analysis of 968 adults with acute myeloid leukemia (AML) on 5 recent Southwest Oncology Group trials to understand how the nature of AML changes with age. Older study patients with AML presented with poorer performance status, lower white blood cell counts, and a lower percentage of marrow blasts.
Frederick R, Appelbaum, Holly, Gundacker, David R, Head, Marilyn L, Slovak, Cheryl L, Willman, John E, Godwin, Jeanne E, Anderson, Stephen H, Petersdorf   +7 more
openaire   +3 more sources

Pseudoplatelets in acute myeloid leukemia [PDF]

Blood, 2015
![Figure][1] A 19-year-old man presented with fever and gum pain for 2 weeks. Physical examination revealed pallor, gingival hyperplasia, and cervical and axillary lymphadenopathy. Automated blood count demonstrated 115 × 103/mm3 white blood cells, 10.7 g/dL of hemoglobin, hematocrit 31.5%,
Randall Y. Chan, Maria Vergara-Lluri
openaire   +2 more sources

Turning Unpredictable Biomolecule Adsorption to Controlled Corona Formation: Focus on Carbon Nanomaterials

Advanced Materials, EarlyView.
Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou, Yalei Hu, Jie Yu, Naoki Komatsu, Yuta Nishina, Alberto Bianco   +5 more
wiley   +1 more source