Results 111 to 120 of about 185,904 (310)

The effects of dexamethasone and tetradecanoyl phorbol acetate on plasminogen activator release by human acute myeloid leukemia cells [PDF]

, 1983
EL Wilson, P Jacobs, EB Dowdle
openalex   +1 more source

Deciphering the Role and Mechanism of Decidual Monocyte‐Derived Macrophage Infiltration in Obstetric Antiphospholipid Syndrome at Single‐Cell Resolution

Advanced Science, EarlyView.
This study uncovers a novel mechanism and therapeutic targets in obstetric antiphospholipid syndrome (OAPS). Antiphospholipid antibody/ß2‐glycoprotein I complex boosts CCL2 and TNF‐α expression in decidual macrophages via TLR4‐NF‐κB. CCL2 accumulates on endothelial surfaces via ACKR1, recruiting monocyte‐derived CCR2+ macrophages, driving inflammation,
Rui Gao, Pingying Qing, Hanxiao Chen, Zhengyan Hu, Qiaoran Yang, Chenyang Lu, Huimin Liu, Rujun Zeng, Yuanting Tang, Fan Yu, Jinbiao Han, Xin Liao, Xun Zeng, Lang Qin   +13 more
wiley   +1 more source

Cryo‐Inactivated Cancer Cells Derived Magnetic Micromotors for Tumor Immunotherapy

Advanced Science, EarlyView.
Cryo‐inactivated cancer cell‐based magnetic micromotors are developed for synergistic tumor immunotherapy via magnetic targeting. These micromotors can induce ferroptosis and immunogenic cell death, deliver tumor antigens, and activate the Mn2+‐dependent cGAS‐STING pathway. The system effectively suppresses tumor progression, recurrence, and metastasis,
Qingfei Zhang, Gaizhen Kuang, Wenzhao Li, Yuanjin Zhao   +3 more
wiley   +1 more source

Enhancing effect of β-elemene emulsion on chemotherapy with harringtonine, aclacinomycin, and Ara-c in treatment of refractory/relapsed acute myeloid leukemia

, 1969
Cuiping Zheng, Xiaoping Cai, Shenghao Wu, Zhen Liu, Yuejian Shi, Wenjin Zhou   +5 more
openalex   +1 more source

Short-term culture of acute myeloid leukemia blasts: analysis of acquired susceptibility to activated natural killer cells [PDF]

, 1986
Philippe Moingeon, A Ythier, A Nowill, L Delmon, C Bayle, JL Pico, C Bohuon, T Hercend   +7 more
openalex   +1 more source

A ROS‐Responsive Dual‐Targeting Drug Nanocarrier Serving as a GSI Synergist and Ferroptosis Sensitizer for T‐Cell Acute Lymphoblastic Leukemia

Advanced Science, EarlyView.
A self‐assembling nanotherapeutic strategy is designed—CD38‐PHD/G‐NPs, which released γ‐secretase inhibitor first, followed by adaptive dihydroartemisnin release in response to elevated reactive oxygen species levels. This controlled, sequential release strategy maximizes the synergistic anti‐leukemic efficacy of two agents with distinct mechanisms of ...
Ruinan Jia, Yang Liu, Jilong Xiao, Yuan Xia, Xin Zhao, Huixian Ma, Jingjing Ye, Zhiyue Zhang, Tao Sun, Chunyan Ji   +9 more
wiley   +1 more source

Human acute unclassified leukemia with a unique t(4;17) chromosomal translocation expresses T lymphoid and myeloid surface antigens after in vitro culture [PDF]

, 1987
A Ganser, G Heil, T Bohm, CR Bartram, A Raghavachar, F Carbonell, D Hoelzer   +6 more
openalex   +1 more source

CXCR1 Depletion in Ly6C+ cDC2 Alleviates Acute Lung Injury via Modulation of Th17/Treg Balance

Advanced Science, EarlyView.
Pro‐inflammatory Ly6C⁺ cDC2s are identified as key effector cells mediating Cxcr1 signaling, driving the progression of ALI. Ly6C⁺ cDC2s release high levels of Il‐6 and Il‐1β, inducing Th17 differentiation. Cxcr1 deficiency reduces Il‐6 and Il‐1β production from Ly6C⁺ cDC2s through suppressing MEK1/ERK /NF‐κB signaling, thereby shifts naïve T cells ...
Shenghui Li, Wei Zhuang, Yang Wang, Hao Qin, Xichun Qin, Xianliang Yan, Xuefei Hu, Xiucheng Liu, Chang Chen   +8 more
wiley   +1 more source

Acute myeloid leukemia (AML) in Down's syndrome is highly responsive to chemotherapy: experience on Pediatric Oncology Group AML Study 8498 [see comments] [PDF]

, 1992
Y. Ravindranath, Esteban Abella, J. Krischer, Jennifer Wiley, S Inoue, M. Brennan Harris, A Chauvenet, CS Alvarado, Ronald L. Dubowy, A. Kim Ritchey   +9 more
openalex   +1 more source

A Network‐Driven Framework for Drug Response Precision Prediction of Acute Myeloid Leukemia

Advanced Science, EarlyView.
A network‐based precision medicine platform, named NetAML is offered for personalized treatment of AML. It combines network analysis and machine learning to develop 87 models predicting drug sensitivity for clinical drugs. NetAML identifies interpretable gene signatures that drive differential drug responses, enabling the prediction of individual ...
Yinyin Wang, Rui Liu, Yinnan Zhang, Xiang Luo, Chengzhuang Yu, Shentong Fang, Ninghua Tan, Jing Tang   +7 more
wiley   +1 more source