Results 201 to 210 of about 311,440 (293)

Targeting TLK2 with antisense oligonucleotides as a new strategy in acute myeloid leukemia. [PDF]

Front Oncol
Lin HY, Khou S, Lind E, de Oliveira Rebola KG, Dean A, Zhang H, Tolentino A, Maazi H, Revenko A, Agarwal A.   +9 more
europepmc   +1 more source

Integrating Single‐Cell and Spatial Transcriptomes in HGSOC to Decipher the Metastasis‐Associated Biomarkers

iNew Medicine, EarlyView.
ABSTRACT High‐grade serous ovarian cancer (HGSOC) is the most common and lethal histological subtype of ovarian cancer. This study aimed to identify peritoneal metastasis‐associated biomarkers of HGSOC to provide directions for subsequent treatment. Transcriptome data were extracted from the GEO database and literature. Differential expression analysis,
Jing Zhu, Zhicheng Yu, Yang Zhang, Hui Hong, Xiaoli Wang, Shan Jiang, Ying Zhou, Cheng Peng, Hongbo Chen   +8 more
wiley   +1 more source

Landscape of circular RNAs in acute myeloid leukemia and their clinical significance. [PDF]

NPJ Precis Oncol
Nguyen TH, Nguyen MH, Nguyen HN, Erkers T, Östling P, Bohlin A, Österroos A, Jafari R, Orre LM, Lehtiö J, Lehmann S, Kallioniemi O, Pawitan Y, Vu TN.   +13 more
europepmc   +1 more source

Clinical and functional significance of circular RNAs in cytogenetically normal AML [PDF]

, 2020
al., et, Papaioannou, Dimitrios, Uy, Geoffrey L.   +2 more
core   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

The proteostasis network is a therapeutic target in acute myeloid leukemia.

Blood
Lam K, Kim YJ, Tan EL, Ong CM, Liu AZ, Zhou FJ, Sunshine MJ, Chua BA, Vicenzi S, Chen K, Yu H, Ford PW, Zhou JH, Hong Y, Bennett EJ, Crews LA, Ball ED, Signer RAJ.   +17 more
europepmc   +1 more source

Characterization of the clonal hierarchy and immunophenotype of PTPN11 mutations in acute myeloid leukemia. [PDF]

JCI Insight
Fobare S, Sharpe C, Quinn K, Bryant K, Miles LA, Bowman RL, Cheney C, Furby C, Long M, Fyock K, Wronowski B, Lerma JR, Mrózek K, Nicolet D, Sesterhenn TM, Johnstone ME, Pan J, Rai SN, Pasare C, Zimmermann N, Yu WM, Qu CK, Carroll A, Stone R, Wang ES, Kolitz J, Powell B, Perentesis JP, Eisfeld AK, Hertlein E, Byrd JC.   +30 more
europepmc   +1 more source

Evaluation of FilmArray Multiplex PCR Test Results in Bloodstream Infections in Oncological Patients

Journal of Clinical Laboratory Analysis, EarlyView.
In this study conducted at an oncology hospital, BCID2 panel results for the rapid identification of microorganisms and resistance genes in positive blood culture samples were compared with conventional culture methods. The BCID2 panel provided faster results and showed a high correlation with traditional methods.
İpek Mumcuoğlu, Sevgi Şahin, Esra Tavukcu, Neşe İnan, Ayşe Semra Güreser, Serap Süzük Yıldız, Tuba Dal   +6 more
wiley   +1 more source

The Application Value of Flow Cytometry‐Based Peripheral Blood Leukocyte Classification in Screening for Acute Leukemia and Posttreatment Monitoring

Journal of Clinical Laboratory Analysis, EarlyView.
Example of leukocyte classification results by FCM. The 16 cell populations are displayed in different colors according to the set gate logic. ABSTRACT Objective Assess the application value of flow cytometry (FCM) for peripheral blood leukocyte (PBL) classification in acute leukemia (AL) screening and monitoring.
Penghua Yan, Lianfeng Wu, Xiangyang Lin, Hong Lu, Jingjing Qian   +4 more
wiley   +1 more source