Results 201 to 210 of about 1,795,367 (304)

The FOXQ1/SSBP2 Regulatory Axis Drives Malignant Progression of Melanoma

Molecular Carcinogenesis, EarlyView.
ABSTRACT Melanoma is a highly aggressive skin cancer with poor prognosis, often linked to excessive UV exposure. Despite advancements in immunotherapy and targeted treatments, melanoma's invasiveness and metastatic potential remain significant challenges.
Xiaoyu Zhang, Yu Hou, Jiahui Liu, Yuehua Han, Jiangang Feng   +4 more
wiley   +1 more source

Itraconazole induced ferroptosis in acute myeloid leukemia cells through TP53INP1. [PDF]

Front Mol Biosci
Qi Y, Han C, Lin Y, Cheng S, She Y, Zhang M, Xie H, Yang G, Zeng D.   +8 more
europepmc   +1 more source

JAK2 Variant and Parkinsonian Syndromes: Coincidence or Pathophysiological Link?

Movement Disorders Clinical Practice, EarlyView.
Abstract Background JAK2 variants are a hallmark of myeloproliferative neoplasms (MPNs), including polycythemia vera and essential thrombocythemia. These disorders are often associated with thrombotic and inflammatory complications. From a movement disorder perspective, chorea is a rare but well‐recognized neurological occurrence in this context ...
Elena Ardila Jurado, Koustubh Bavdhankar, Divyani Garg, Francesca Magrinelli, Huw R. Morris, Kailash P. Bhatia   +5 more
wiley   +1 more source

Acute Myeloid Leukemia Subtype-Specific Prognostic Value of NGS in the Setting of Intensive Chemotherapy. [PDF]

Am J Hematol
Bolarinwa A, Al-Kali A, Alkhateeb HB, Mangaonkar AA, Saliba AN, Torghabeh MH, Matin A, Elliott MA, Litzow MR, Hogan WJ, Shah MV, Patnaik MM, Pardanani A, Foran JM, Badar T, Murthy HS, Punwani N, Palmer JM, Sproat LZ, Chen D, Reichard KK, He R, Viswanatha DS, Zepeda-Mendoza CJ, Gangat N, Begna KH, Tefferi A.   +26 more
europepmc   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

A systems biology approach to find representative genes in Acute Myeloid Leukemia. [PDF]

PLoS One
Aghajan B, Ghaemi MR, Mosammam AM, Heshmati E, Khalifeh K.   +4 more
europepmc   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

miR-330-3p Inhibits the Development of Acute Myeloid Leukemia by Targeting SYTL4. [PDF]

APMIS
Zhang Y, Xu A, Qin H, Feng D, Tian C, Lin C.   +5 more
europepmc   +1 more source

Molecular Glue Degraders in Early Development for Cancer Therapy

Medicinal Research Reviews, EarlyView.
ABSTRACT Molecular glue degraders are an emerging class of small molecule allosteric modulators that induce or stabilize protein‐protein interactions, enabling targeted degradation of previously intractable proteins. By redirecting E3 ligases to recognize neosubstrates, proteins that are not typically recognized by a specific E3 ubiquitin ligase, they ...
E. Sila Ozdemir, Hyunbum Jang, Ozlem Keskin, Attila Gursoy, Ruth Nussinov   +4 more
wiley   +1 more source

Leclercia adecarboxylata cellulitis in a neutropenic Thai child with acute myeloid leukemia. [PDF]

IDCases
Thiamprasert T, Ruangsirinusorn P, Lektrakul Y, Thanee C.   +3 more
europepmc   +1 more source