Results 231 to 240 of about 356,633 (356)

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Expression and prognostic significance of cathepsin D in acute myeloid leukemia. [PDF]

Medicine (Baltimore)
Han H, Huang Y, Xie J, Liu J, Wang W.
europepmc   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Research advances in the adjunctive diagnosis of acute myeloid leukemia. [PDF]

Front Oncol
Xie W, Jiang X, Huang J, Qin M, Bi Z.
europepmc   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

The French-American-British classification system for acute myeloid leukemia. [PDF]

Haematologica
Pollyea DA.
europepmc   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

NIPA1 depletion in tumor-associated macrophages via IGFBP2/EGFR attenuates acute myeloid leukemia progression and chemoresistance. [PDF]

Ann Hematol
Tang S, Sheng L, Mu Q, Wang Y, Chen L, Xu K, Zhou M, Xu Z, Wu A, Ouyang G.   +9 more
europepmc   +1 more source

Multimodal Analysis of White Blood Cell Differentiation in Acute Myeloid Leukemia Patients using a β-Variational Autoencoder [PDF]

G Mert, Ario Sadafi, Raheleh Salehi, Nassir Navab, Carsten Marr   +4 more
openalex   +1 more source

Rib Ewing Sarcomas in Children and Young Adults: A Large National Retrospective Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Purpose Ewing sarcoma (ES) is the most prevalent malignant thoracic tumor in childhood and young adults. This study reports the outcome of a national cohort treated in an international prospective trial for a localized rib ES, with a long follow‐up.
Audrey Claren, Alexandre Beige, Magali Morelle, Jérôme Doyen, Cyril Lervat, Luc Ollivier, Cécile Vérité, Perrine Marec‐Bérard, Maria Jolnerovski, Anne Ducassou, Valentine Martin, Line Claude, French Multidisciplinary Working Group on Bone Primary Tumours (GROUPOS), GSF (French Sarcoma Group), GETO (Bone Tumour Study Group) and SFCE (French Society for the Fight against Childhood and Adolescent Cancer and Leukaemia)   +14 more
wiley   +1 more source