Results 21 to 30 of about 569,111 (191)

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia.

Blood, 2016
The World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues was last updated in 2008. Since then, there have been numerous advances in the identification of unique biomarkers associated with some myeloid ...
D. Arber, A. Orazi, R. Hasserjian, J. Thiele, M. Borowitz, M. L. Le Beau, C. Bloomfield, M. Cazzola, J. Vardiman   +8 more
semanticscholar   +1 more source

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.

New England Journal of Medicine, 2013
BACKGROUND Many mutations that contribute to the pathogenesis of acute myeloid leukemia (AML) are undefined. The relationships between patterns of mutations and epigenetic phenotypes are not yet clear.
T. Ley, C. Miller, L. Ding, Benjamin J. Raphael, A. Mungall, A. G. Robertson, K. Hoadley, T. Triche, P. Laird, J. Baty, L. Fulton, R. Fulton, S. Heath, Joelle M. Kalicki-Veizer, C. Kandoth, J. Klco, D. Koboldt, K. Kanchi, S. Kulkarni, T. Lamprecht, D. Larson, Ling Lin, Charles Lu, M. McLellan, Joshua F. McMichael, J. Payton, Heather K. Schmidt, D. Spencer, M. Tomasson, J. Wallis, L. Wartman, M. Watson, J. Welch, M. Wendl, Adrian Ally, M. Balasundaram, I. Birol, Y. Butterfield, Readman Chiu, Andy Chu, E. Chuah, Hye-Jung E. Chun, R. Corbett, Noreen Dhalla, R. Guin, A. He, Carrie Hirst, M. Hirst, R. Holt, Steven P. Jones, A. Karsan, Darlene Lee, H. Li, M. Marra, Michael Mayo, Richard A. Moore, K. Mungall, J. Parker, E. Pleasance, Patrick Plettner, J. Schein, D. Stoll, Lucas Swanson, Angela Tam, N. Thiessen, R. Varhol, N. Wye, Yongjun Zhao, S. Gabriel, G. Getz, C. Sougnez, L. Zou, Mark D. M. Leiserson, Fabio Vandin, Hsin-Ta Wu, F. Applebaum, S. Baylin, Rehan Akbani, B. Broom, Ken Chen, Thomas C. Motter, Khanh Nguyen, J. Weinstein, Nianziang Zhang, M. Ferguson, C. Adams, Aaron D. Black, Jay Bowen, J. Gastier-Foster, T. Grossman, T. Lichtenberg, L. Wise, Tanja Davidsen, John A. Demchok, K. Shaw, Margi Sheth, H. Sofia, Liming Yang, J. Downing, G. Eley   +99 more
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Unified classification and risk-stratification in Acute Myeloid Leukemia

Nature Communications, 2022
Clinical recommendations for Acute Myeloid Leukemia (AML) classification and risk-stratification remain heavily reliant on cytogenetic findings at diagnosis, which are present in
Yanis Tazi, J. E. Arango-Ossa, Yangyu Zhou, E. Bernard, Ian Thomas, A. Gilkes, S. Freeman, Yoann Pradat, S. Johnson, R. Hills, R. Dillon, M. Levine, D. Leongamornlert, A. Butler, A. Ganser, L. Bullinger, K. Döhner, O. Ottmann, R. Adams, H. Döhner, P. Campbell, A. Burnett, M. Dennis, N. Russell, S. Devlin, B. Huntly, E. Papaemmanuil   +26 more
semanticscholar   +1 more source

A one-mutation mathematical model can explain the age incidence of acute myeloid leukemia with mutated nucleophosmin (NPM1) [PDF]

, 2008
Acute myeloid leukemia with mutated NPM1 gene and aberrant cytoplasmic expression of nucleophosmin (NPMc+acute myeloid leukemia) shows distinctive biological and clinical features.
A. Cappuccio, A. Ganser, A. Liso, B. Falini, B. Lö, C. Thiede, F. Castiglione, F. Mandelli, F. Michor, F. Stracci, G. Ehninger, H. Dö, J. Krauter, K. Dö, M. Schaich, M.F. Martelli, M.P. Martelli, N. Bolli, P.J..M. Valk, R.F. Schlenk, S. Amadori, S. Schnittger, T. Haferlach   +22 more
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Integrated genome-wide genotyping and gene expression profiling reveals BCL11B as a putative oncogene in acute myeloid leukemia with 14q32 aberrations [PDF]

, 2014
Acute myeloid leukemia is a neoplasm characterized by recurrent molecular aberrations traditionally demonstrated by cytogenetic analyses. We used high density genome-wide genotyping and gene expression profiling to reveal acquired cryptic abnormalities ...
Abbas, S. (Saman), Abbas, Z.G. (Zabiollah), Beverloo, H.B. (Berna), Chu, I.W.T. (Isabel), Drunen, E. (Ellen) van, Galen, J.F. (Janneke ) van, Geertsma-Kleinekoort, W.M.C. (Wendy), Hoogenboezem, R.M. (Remco), Kavelaars, F.G. (François), Koenders, J.E. (Jasper), Löwenberg, B. (Bob), Mahamoud, S. (Souad), Peeters, J.K. (Justine), Sanders, M.A. (Mathijs), Valk, P.J.M. (Peter), Zeilemaker, A. (Annelieke)   +15 more
core   +3 more sources

Genomic Classification and Prognosis in Acute Myeloid Leukemia.

New England Journal of Medicine, 2016
BACKGROUND Recent studies have provided a detailed census of genes that are mutated in acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity defines the pathophysiology of AML and informs clinical practice ...
E. Papaemmanuil, M. Gerstung, L. Bullinger, V. Gaidzik, P. Paschka, Nicola D. Roberts, N. Potter, M. Heuser, F. Thol, N. Bolli, G. Gundem, P. Van Loo, I. Martincorena, P. Ganly, L. Mudie, Stuart Mclaren, S. O’Meara, K. Raine, David Jones, J. Teague, A. Butler, M. Greaves, A. Ganser, K. Döhner, R. Schlenk, H. Döhner, P. Campbell   +26 more
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RUNX oncoproteins and miRNA networks [PDF]

, 2017
News on: An AML1-ETO/miR-29b-1 regulatory circuit modulates phenotypic properties of acute myeloid leukemia cells by Zaidi et al. Oncotarget. 2017; 8:39994-40005.
Borland, Gillian, Hay, Jodie, Neil, James C.   +2 more
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Congenital acute myeloid leukemia with unique translocation t(11;19)(q23;p13.3) [PDF]

, 2015
Congenital leukemia is rarely encountered in clinical practice, even in tertiary children's hospitals. Leukemia may cause significant coagulopathy, putting the patient at risk of intracranial hemorrhage.
Bandt, S. Kathleen, Frater, John L, Hurth, Kyle, Kulkarni, Shashikant, Leonard, Jeffrey R, Rao, Rakesh, Wambach, Jennifer A, White, Francis V, Yarbrough, Chester K   +8 more
core   +3 more sources

T(6;9)(p22;q34)/DEK-NUP214-rearranged pediatric myeloid leukemia: An international study of 62 patients [PDF]

, 2014
Acute myeloid leukemia with t(6;9)(p22;q34) is listed as a distinct entity in the 2008 World Health Organization classification, but little is known about the clinical implications of t(6;9)-positive myeloid leukemia in children.
Adachi, S. (Susumu), Auvrignon, A. (Anne), Beverloo, H.B. (Berna), Cayuela, J.-M. (Jean-Michel), Chilton, L. (Lucy), Coenen, E.A. (Eva), Forestier, E. (Erik), Fornerod, M.W.J. (Maarten), Haas, V. (Valerie) de, Harbott, J. (Jochen), Harrison, C.J. (Christine), Hasle, H. (Henrik), Heuvel-Eibrink, M.M. (Marry) van den, Inaba, H. (Hiroto), Johansson, B. (Bert), Kaspers, G.J.L. (Gertjan), Kerndrup, G. (Gitte), Liang, D. (Der), Locatelli, F. (Franco), Masetti, R. (Riccardo), Neuhoff, N. (Nils) von, Perot, C. (Christine), Raimondi, S.C. (Susana), Reinhardt, K. (Katarina), Sandahl, J.D. (Julie Damgaard), Tomizawa, D. (Daisuke), Zecca, M. (Marco), Zwaan, C.M. (Michel)   +27 more
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NCCN Guidelines Insights: Acute Myeloid Leukemia, Version 2.2021.

The Journal of the National Comprehensive Cancer Network, 2021
The NCCN Guidelines for Acute Myeloid Leukemia (AML) provide recommendations for the diagnosis and treatment of adults with AML based on clinical trials that have led to significant improvements in treatment, or have yielded new information regarding ...
D. Pollyea, D. Bixby, A. Perl, V. Bhatt, J. Altman, F. Appelbaum, M. de Lima, A. Fathi, J. Foran, I. Gojo, Aric Hall, Meagan A. Jacoby, J. Lancet, G. Mannis, G. Marcucci, Mike G Martin, A. Mims, Jadee L. Neff, R. Nejati, R. Olin, M. Percival, T. Prebet, Amanda C. Przespolewski, D. Rao, F. Ravandi-Kashani, P. Shami, R. Stone, S. Strickland, K. Sweet, P. Vachhani, M. Wieduwilt, K. Gregory, Ndiya Ogba, M. Tallman   +33 more
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