Results 81 to 90 of about 476,540 (289)

Bacterial Infections in End-Stage Liver Disease: Implications for Liver Transplantation

Transplantology
Bacterial infections are a common complication in patients with decompensated liver cirrhosis. The complex landscape of cirrhosis, characterized by immune paralysis and an exhausted response to exogenous triggers, explains the higher prevalence of such ...
Alberto Ferrarese, Marco Senzolo, Anna Maria Cattelan, Lolita Sasset, Sara Battistella, Alberto Zanetto, Giacomo Germani, Francesco Paolo Russo, Martina Gambato, Filippo Pelizzaro, Stefania Vio, Domenico Bassi, Umberto Cillo, Patrizia Burra   +13 more
doaj   +1 more source

Brain edema : a valid endpoint for measuring hepatic encephalopathy? [PDF]

, 2016
Hepatic encephalopathy (HE) is a major complication of liver failure/disease which frequently develops during the progression of end-stage liver disease.
Bémeur, Chantal, Cooper, Arthur J. L., Cudalbu, Cristina, Dam, Gitte, Rose, Christopher, Thrane, Alexander S.   +5 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Liver transplantation for acute liver failure and acute-on-chronic liver failure

American Journal of Transplantation
Acute liver failure (ALF) and acute-on-chronic liver (ACLF) are distinct phenotypes of liver failure and, thus, need to be compared and contrasted for appropriate management. There has been a significant improvement in the outcomes of these patients undergoing liver transplantation (LT).
Anand V. Kulkarni, Thierry Gustot, K. Rajender Reddy   +2 more
openaire   +2 more sources

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Plasmin-mediated proteolysis of von Willebrand factor in patients with acute and chronic liver disease

Research and Practice in Thrombosis and Haemostasis
Background: In patients with acute and chronic liver disease, von Willebrand factor (VWF) antigen levels are markedly elevated, whereas a disintegrin and metalloproteinase with thrombospondin type 1 motifs, member 13 (ADAMTS13) activity is often reduced.
Hinde El Otmani, Marilena Stamouli, Jelle Adelmeijer, William Bernal, Coen Maas, Vishal C. Patel, Ton Lisman   +6 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Clinical Characteristics and Outcome of Acute on Chronic Liver Failure Patients at Fatmawati General Hospital

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2020
Background: Acute-on-chronic liver failure (ACLF) is a syndrome characterized by acute liver decompensation with extrahepatic organ failure in patients with pre-existing liver disease causing high short-term mortality.
Nikko Darnindro, Annela Manurung, Edi Mulyana, Arnold Harahap, Marlina Dewiastuti, Fenandri Fadillah Fedrizal, Mohammad Sadhyo Prabhasworo   +6 more
doaj   +1 more source

Cause and timing of first allograft failure in orthotopic liver transplantation: A study of 177 consecutive patients [PDF]

, 1991
The cause and timing of first liver allograft failure was evaluated in 177 patients who underwent a second liver transplant between January 1984 and December 1988.
Busuttil, Carithers, Demetris, Demetris, Klintmalm, Krom, Kusne, Lerut, Maddrey, Polson, Ringe, Scharschmidt, Shaw, Starzl, Starzl, Starzl, Starzl, Starzl, Tzakis, van Thiel, Wozney, Yanaga, Yanaga   +22 more
core   +1 more source