Results 61 to 70 of about 1,680,433 (254)

NCLX Inhibition plus Ca2+ Delivery Potentiates Electroporation and Antitumor Immunity in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Electroporation combined with NCLX inhibition and Ca2+ delivery induces mitochondrial Ca2+ overload in PDAC cells, triggering pyroptosis, DAMP release, and antitumor immune activation. Simultaneously, suppression of tumor‐derived SPP1 weakens SPP1–CD44 signaling and remodels macrophages toward an antitumor phenotype, thereby enhancing CD8+ T‐cell ...
Chuanbing Zhao, Long He, Yu Lu, Zanglong Deng, Hongzhen Wei, Yunpeng Zhang, Ming Yang, Tao Yin   +7 more
wiley   +1 more source

Practical guidelines for acute pancreatitis

, 2010
Introduction: The following is a summary of the official guidelines of the Italian Association for the Study of the Pancreas regarding the medical, endoscopic and surgical management of acute pancreatitis.
A. Zerbi, R. Pezzilli, DELLE FAVE, Gianfranco, C. Bassi, V. Di Carlo, O. N. Acute Pancreatitis Working Group Of The Italian Association For The Study Of The Pancreas, Fantini MP, MORSELLI LABATE, ANTONIO MARIA, Gaia E, Delle Fave G, Zerbi A, Billi, P, Del Chiaro, M, De Rai P, GABBRIELLI, Armando, FANTINI, MARIA PIA, Brazzi, Luca, Scarpellini, P, Nicoletti R., Pezzilli R, Gaia, E, DALLOLIO, LAURA, Balzano G, Casadei R, Gabbrielli, A, Morselli Labate AM, Rabitti, P, Del Chiaro M, FABBRI, GIULIANA, ...], Mutignani M, G.F. Delle Fave, De Rai, P, D'Alessandro A, Balzano, G, Castoldi L, Scarpellini P, PEZZILLI, RAFFAELE, Bassi, C, BASSI, Claudio, Di Carlo V, D'Alessandro, A, Casadei, R, Brazzi L, Dall'Olio L, Calculli L, Nicoletti, R, Mariani A, Uomo G, Fabbri G, CALCULLI, LUCIA, Mariani, A, Rabitti P, Castoldi, L, CASADEI, RICCARDO, FRULLONI, Luca, G. F. Delle Fave, Mutignani, M, Uomo, G, Frulloni, L, Brazzi, L, Billi P   +61 more
core   +2 more sources

Unraveling the role of MCM7 in cancer: a comprehensive analysis and functional validation from pan-cancer to lung adenocarcinoma

Frontiers in Oncology
BackgroundMinichromosome maintenance protein 7 (MCM7), an integral component of the DNA replication licensing complex, has been implicated in diverse human malignancies.
Xiaozhou Xie, Xiaozhou Xie, Jie Li, Yuchen Jia, Yuchen Jia, Yuxi Zhang, Yuxi Zhang, Jiongdi Lu, Jiongdi Lu, Feng Cao, Feng Cao, Fei Li, Fei Li   +12 more
doaj   +1 more source

Cohort profile: the Swedish Pancreatitis Cohort (SwePan)

BMJ Open, 2022
Purpose The Swedish Pancreatitis Cohort (SwePan) was designed to study long-term outcomes following an episode of acute pancreatitis. It can also be used to study various risk factors for developing acute pancreatitis.Participants The SwePan is a ...
Bei Yang, Magnus Nilsson, John Maret-Ouda, Mats Lindblad, Omid Sadr-Azodi, Urban Arnelo, Daniel Selin   +6 more
doaj   +1 more source

Acinar‐Derived Organoids Reveal Stage‐Specific Control of Acinar Plasticity

Advanced Science, EarlyView.
An acinar‐derived organoid system maintains adult pancreatic acinar identity ex vivo, converts it along an ordered acinar‐to‐ductal‐like trajectory, and then partially restores it. Each transition carries its own signal requirement, with EGF/EGFR initiating conversion and a staged glucocorticoid–IGF1R switch driving redifferentiation.
Yongfei Hou, Siyu Li, Chunying Li, Zhifan Lin, Dan He, Li Yang, Liping Fu, Qianyue Zhang, Tianping Zhou, Yao Yao, Xiaolei Yin   +10 more
wiley   +1 more source

Klebsiella predominance in peripancreatic microbial spectrum is associated with the severity of infected pancreatic necrosis

BMC Infectious Diseases
Background Infectious pancreatic necrosis (IPN) is associated with the prognosis of acute pancreatitis (AP). The correlation between microbial diversity in the peripancreatic region and AP severity remains unclear.
Xiaolan Guo, Yao Xu, Kaiwei Li, Jingzhu Zhang, Zhihui Tong, Weiqin Li, Donghuang Hong   +6 more
doaj   +1 more source

The use of sivelestat sodium among patients with acute pancreatitis and early organ failure: a single-center retrospective cohort study

Frontiers in Medicine
BackgroundThis study aimed to investigate whether neutrophil elastase inhibitor (sivelestat sodium) was associated with decreased duration of organ failure in patients with acute pancreatitis (AP) and early organ failure.MethodsBetween January 2022 and ...
Zongwen Zhang, Xinsen Zou, Yiting Guan, Siyu Zhang, Mingfeng Huang, Hong Lin, Jing Zhou, Lin Gao, Wenjian Mao, Wenjian Mao, Bin Yao, Xiangcheng Zhang, Lu Ke, Lu Ke, Zhihui Tong, Yuxiu Liu, Weiqin Li, Weiqin Li   +17 more
doaj   +1 more source

Effect of Baicalin on inflammatory mediator levels and microcirculation disturbance in rats with severe acute pancreatitis [PDF]

, 2008
Objective: To investigate the effect of Bacailin on inflammatory mediator levels and microcirculation disturbance in severe acute pancreatitis (SAP) rats and explore its therapeutic mechanism on this disease. Methods: SAP model rats were randomly divided
Hua Tian, Qian Ye, Ru-Jun Xu, Xin-Ge Jiang, Li Chen, Yang Cai, Xiping Zhang, Qi Xie, Wenqin Yuan, Chen-Jun Wu   +9 more
core  

CaMKIIδ Phosphorylates AUP1 to Promote Pancreatic Tissue Repair and Acinar‐to‐Ductal Metaplasia Formation via Mediating PERK‐Dependent Unfolded Protein Responses

Advanced Science, EarlyView.
CaMKIIδ–AUP1 signaling maintains PERK‐dependent ER homeostasis during ADM‐mediated pancreatic repair. ABSTRACT Pancreatic repair after acute pancreatitis (AP) is essential for restoring tissue integrity, but the intrinsic mechanisms coordinating acinar plasticity and regeneration remain poorly understood.
Yonghao Chen, Ziying Han, Zihan Yang, Jie Wu, Kaixin Peng, Xiuli Zhang, Bintao Qiu, Jianqiang Wu, Xiaomin Hu, Dong Wu, Li Wen   +10 more
wiley   +1 more source

Acute pancreatitis [PDF]

, 2020
Acute pancreatitis is an unpredictable and potentially lethal disease. The prognosis mainly depends on the development of organ failure and secondary infection of pancreatic or peripancreatic necrosis.
Verdonk, Robert C., Besselink, MGH, Besselink, Marc G., Bruno, Marco, Boxhoorn, Lotte, Boxhoorn, L, Verdonk, RC, Bouwense, Stefan A., Bouwense, SAW, Boermeester, Marja A., Voermans, RP, Boermeester, MA, Voermans, Rogier P., Bruno, Marco J., van Santvoort, HC, van Santvoort, Hjalmar C., Boxhoorn, L.   +16 more
core   +1 more source