Results 91 to 100 of about 985,459 (353)

Optimal combinations of acute phase proteins for detecting infectious disease in pigs

Veterinary Research, 2011
The acute phase protein (APP) response is an early systemic sign of disease, detected as substantial changes in APP serum concentrations and most disease states involving inflammatory reactions give rise to APP responses.
P. Heegaard, A. Stockmarr, M. Piñeiro, R. Carpintero, F. Lampreave, F. M. Campbell, F. M. Campbell, P. Eckersall, M. Toussaint, E. Gruys, N. S. Sørensen   +10 more
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

MYCOBACTERIUM TUBERCULOSIS BIOLOGICAL PROPERTIES AND CHARACTERISTICS OF THE INFLAMMATORY REACTION IN PATIENTS WITH INFILTRATIVE PULMONARY TUBERCULOSIS

Инфекция и иммунитет, 2014
Host-pathogen relations were analyzed on basis of the results of examinations of 42 patients with newly diagnosed, previously untreated infiltrative pulmonary tuberculosis (IPT) with regard for the biological characteristics of Mycobacterium tuberculosis
O. T. Titarenko, M. E. Dyakova, O. A. Manicheva, D. S. Esmedlyaeva, M. Z. Dogonadze, N. P. Alexeyeva, T. L. Perova, N. N. Melnikova   +7 more
doaj   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function

Journal of Experimental Medicine, 2010
Acute-phase proteins (APPs) are an evolutionarily conserved family of proteins produced mainly in the liver in response to infection and inflammation.
L. Sander, L. Sander, S. Sackett, U. Dierssen, N. Beraza, R. Linke, Michael Müller, J. Blander, F. Tacke, C. Trautwein   +9 more
semanticscholar   +1 more source

STUDIES OF ACUTE-PHASE PROTEIN. II. LOCALIZATION OF Cx-REACTIVE PROTEIN IN HEART IN INDUCED MYOCARDIAL INFARCTION IN RABBITS* [PDF]

, 1963
Irving Kushner, Louis Rakita, Melvin H. Kaplan   +2 more
openalex   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Acute-phase proteins in acute appendicitis. [PDF]

Clinical Chemistry, 1984
F Van Lente, Robert S. Galen
openaire   +2 more sources

"Association between Periodontal Disease and Elevated C-reactive Protein in Acute Myocardial Infarction Patients "

Frontiers in Dentistry, 2006
Statement of problem: Periodontal disease (PD) has been linked to adverse cardiovascular events by unknown mechanisms. C-reactive protein (CRP) is a prognostic marker for cardiovascular disease, with reported elevated serum levels during PD. Purpose: The
G. Radafshar, B. Shad, M. Mirfeizi   +2 more
doaj  

The Immunologic Properties and Identity of Mucopolysaccharides Associated with C-Reactive Protein in Acute Phase Human Serum [PDF]

, 1967
Y. Hokama, Monroe Coleman, Richard F. Riley   +2 more
openalex   +1 more source