Results 131 to 140 of about 1,012,363 (342)

Optimize Individualized Energy Delivery for Septic Patients Using Predictive Deep Learning Models: A Real World Study [PDF]

arXiv
Background and Objectives: We aim to establish deep learning models to optimize the individualized energy delivery for septic patients. Methods and Study Design: We conducted a study of adult septic patients in Intensive Care Unit (ICU), collecting 47 indicators for 14 days.
arxiv  

Off-site production of plasma-activated water for efficient sterilization: the crucial role of high-valence NOx and new chemical pathways [PDF]

Efficient sterilization of pathogens with cleaner methods is a critical concern for environmental disinfection and clinical anti-infective treatment. Plasma-activated water (PAW) is a promising alternative to chemical disinfectants and antibiotics for its strong sterilization ability and not inducing any acute toxicity, and only water and air are ...
arxiv   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Plasma cholesterol homeostasis, HDL remodeling and function during the acute phase reaction[S]

Journal of Lipid Research, 2017
Acute phase reaction (APR) is a systemic inflammation triggered by several conditions associated with lipid profile alterations. We evaluated whether APR also associates with changes in cholesterol synthesis and absorption, HDL structure, composition ...
Francesca Zimetti, Stefano De Vuono, Monica Gomaraschi, Maria Pia Adorni, Elda Favari, Nicoletta Ronda, Maria Anastasia Ricci, Fabrizio Veglia, Laura Calabresi, Graziana Lupattelli   +9 more
doaj  

Effects of human recombinant interleukin-1β on protein synthesis in rat tissues compared with a classical acute-phase reaction induced by turpentine. Rapid response of muscle to interleukin-1β [PDF]

, 1991
Peter E. Ballmer, M.A. McNurlan, B G Southorn, I. S. Grant, P.J. Garlick   +4 more
openalex   +1 more source

CPAISD: Core-penumbra acute ischemic stroke dataset [PDF]

arXiv
We introduce the CPAISD: Core-Penumbra Acute Ischemic Stroke Dataset, aimed at enhancing the early detection and segmentation of ischemic stroke using Non-Contrast Computed Tomography (NCCT) scans. Addressing the challenges in diagnosing acute ischemic stroke during its early stages due to often non-revealing native CT findings, the dataset provides a ...
arxiv  

Quantifying cognitive function in concussed athletes before and after acute exercise using a choice reaction time task [PDF]

, 2014
Following a concussion, cognitive deficits have been shown to last longer than symptom resolution. Currently clinicians rely heavily on symptom emergence following the fundamental exercises of the return to play (RTP) protocol, which may leave athletes ...
Cinelli, Michael E, Ph.D., Ramautar, Stephanie A, M.Sc.   +1 more
core   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Systemic cytokines related to memory function 6–9 months and 12–15 months after SARS-CoV-2 infection

Scientific Reports
Cognitive symptoms persisting beyond the acute phase of COVID-19 infection are commonly described for up to 2 years after infection. The relationship between cognitive performance, in particular episodic memory processes observed chronically after ...
A. Nuber-Champier, G. Breville, P. Voruz, I. Jacot de Alcântara, A. Cionca, G. Allali, P. H. Lalive, L. Benzakour, K.-O. Lövblad, O. Braillard, M. Nehme, M. Coen, J. Serratrice, J.-L. Reny, J. Pugin, I. Guessous, B. N. Landis, F. Assal, Julie Anne Péron   +18 more
doaj   +1 more source