Results 1 to 10 of about 455,793 (260)

Acute-phase proteins: As diagnostic tool

Journal of Pharmacy and Bioallied Sciences, 2011
The varied reactions of the host to infection, inflammation, or trauma are collectively known as the acute-phase response and encompass a wide range of pathophysiological responses such as pyrexia, leukocytosis, hormone alterations, and muscle protein ...
Sachin Jain, Vidhi Gautam, Sania Naseem
doaj   +3 more sources

The Association of Acute Phase Proteins in Stress and Inflammation-Induced T2D. [PDF]

Cells, 2022
Speelman T, Dale L, Louw A, Verhoog NJD.
europepmc   +2 more sources

Acute phase reaction and acute phase proteins [PDF]

Journal of Zhejiang University-SCIENCE B, 2005
A review of the systemic acute phase reaction with major cytokines involved, and the hepatic metabolic changes, negative and positive acute phase proteins (APPs) with function and associated pathology is given. It appears that APPs represent appropriate analytes for assessment of animal health.
Gruys, E., Toussaint, M.J.M., Niewold, T.A., Koopmans, S.J.   +3 more
openaire   +3 more sources

Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis

Nature Communications, 2021
ATTR amyloidosis causes heart failure through the accumulation of misfolded transthyretin in cardiac muscle. Here the authors report a mouse model of ATTR amyloidosis and demonstrate the involvement of protease activity in ATTR amyloid deposition.
Ivana Slamova, Rozita Adib, Stephan Ellmerich, Michal R. Golos, Janet A. Gilbertson, Nicola Botcher, Diana Canetti, Graham W. Taylor, Nigel Rendell, Glenys A. Tennent, Guglielmo Verona, Riccardo Porcari, P. Patrizia Mangione, Julian D. Gillmore, Mark B. Pepys, Vittorio Bellotti, Philip N. Hawkins, Raya Al-Shawi, J. Paul Simons   +18 more
doaj   +1 more source

Clinical Amyloid Typing by Proteomics: Performance Evaluation and Data Sharing between Two Centres

Molecules, 2021
Amyloidosis is a relatively rare human disease caused by the deposition of abnormal protein fibres in the extracellular space of various tissues, impairing their normal function. Proteomic analysis of patients’ biopsies, developed by Dogan and colleagues
Diana Canetti, Francesca Brambilla, Nigel B. Rendell, Paola Nocerino, Janet A. Gilbertson, Dario Di Silvestre, Andrea Bergamaschi, Francesca Lavatelli, Giampaolo Merlini, Julian D. Gillmore, Vittorio Bellotti, Pierluigi Mauri, Graham W. Taylor   +12 more
doaj   +1 more source

CD14 Is an Acute-Phase Protein [PDF]

The Journal of Immunology, 2004
Abstract The origin of soluble CD14 (sCD14) in the circulation is uncertain. To examine whether CD14 could be an acute-phase protein (APP), the levels of sCD14, IL-6, and C-reactive protein were determined by ELISA in serum and synovial fluid (SF) of patients with various arthropathies, and the regulation of CD14 synthesis was examined ...
Bas S, Gauthier BR, Spenato U, Stingelin S, Gabay C   +4 more
openaire   +3 more sources

Amyloid Formation by Globular Proteins: The Need to Narrow the Gap Between in Vitro and in Vivo Mechanisms

Frontiers in Molecular Biosciences, 2022
The globular to fibrillar transition of proteins represents a key pathogenic event in the development of amyloid diseases. Although systemic amyloidoses share the common characteristic of amyloid deposition in the extracellular matrix, they are ...
Giulia Faravelli, Valentina Mondani, P. Patrizia Mangione, P. Patrizia Mangione, Sara Raimondi, Loredana Marchese, Francesca Lavatelli, Monica Stoppini, Alessandra Corazza, Alessandra Corazza, Diana Canetti, Guglielmo Verona, Laura Obici, Graham W. Taylor, Julian D. Gillmore, Sofia Giorgetti, Sofia Giorgetti, Vittorio Bellotti, Vittorio Bellotti, Vittorio Bellotti, Vittorio Bellotti   +20 more
doaj   +1 more source

Calcium Binds to Transthyretin with Low Affinity

Biomolecules, 2022
The plasma protein transthyretin (TTR), a transporter for thyroid hormones and retinol in plasma and cerebrospinal fluid, is responsible for the second most common type of systemic (ATTR) amyloidosis either in its wild type form or as a result of ...
Cristina Cantarutti, Maria Chiara Mimmi, Guglielmo Verona, Walter Mandaliti, Graham W. Taylor, P. Patrizia Mangione, Sofia Giorgetti, Vittorio Bellotti, Alessandra Corazza   +8 more
doaj   +1 more source

Studies of Acute Phase Protein [PDF]

The Journal of Immunology, 1961
Summary Following the injection of I131-labeled BSA into rabbits, CxRP was found to appear in the serum of one half of the animals demonstrating an immune response. The time of appearance of CxRP indicated that the inflammation began coincident with or immediately following the appearance of immune complexes in the circulation.
Irving Kushner, Melvin H. Kaplan
openaire   +1 more source

Disease progression in cardiac transthyretin amyloidosis is indicated by serial calculation of National Amyloidosis Centre transthyretin amyloidosis stage

ESC Heart Failure, 2020
Aims Cardiac transthyretin amyloidosis (ATTR‐CM) is a progressive and fatal condition. Prognosis can be determined at diagnosis according to the National Amyloidosis Centre (NAC) transthyretin amyloidosis (ATTR) stage.
Steven Law, Aviva Petrie, Liza Chacko, Oliver C. Cohen, Sriram Ravichandran, Janet A. Gilbertson, Dorota Rowczenio, Ashutosh Wechalekar, Ana Martinez‐Naharro, Helen J. Lachmann, Carol J. Whelan, David F. Hutt, Philip N. Hawkins, Marianna Fontana, Julian D. Gillmore   +14 more
doaj   +1 more source