Despite induction immunosuppression and the use of aggressive maintenance immunosuppressive regimens, acute allograft rejection following lung transplantation is still a problem with important diagnostic and therapeutic challenges. As well as causing early graft loss and mortality, acute rejection also initiates the chronic alloimmune responses and ...
Mark, Benzimra +2 more
openaire +2 more sources
Biomarkers for Kidney-Transplant Rejection: A Short Review Study
Kidney transplantation is the preferred treatment for end-stage renal failure, but the limited availability of donors and the risk of immune rejection pose significant challenges.
Israa Sharaby +6 more
doaj +1 more source
Pathways to Acute Humoral Rejection [PDF]
Acute humoral rejection, also known as acute vascular rejection, is a devastating condition of organ transplants and a major barrier to clinical application of organ xenotransplantation. Although initiation of acute humoral or vascular rejection is generally linked to the action of antibodies and complement on the graft, other factors such as ischemia,
Jeffrey L. Platt +3 more
openaire +3 more sources
GC/MS-based urine metabolomics analysis of renal allograft recipients with acute rejection
Background Acute renal allograft rejection is a common complication after renal transplantation that often leads to chronic rejection and ultimate graft loss.
Long Zheng +8 more
doaj +1 more source
Non-invasive monitoring of renal transplant recipients: Urinary excretion of soluble adhesion molecules and of the complement-split product C4d [PDF]
Background: The number of inducible adhesion molecules known to be involved in cell-mediated allograft rejection is still increasing. In addition, recent data describe complement activation during acute humoral allograft rejection.
Friedrich, N. +5 more
core +1 more source
Diagnostic value of miRNA-101 and miRNA-27 in acute heart transplant rejection
Objective: to determine the diagnostic value of miRNA-101 and miRNA-27 expression levels for acute hearttransplant rejection. Materials and methods. The study enrolled 46 heart recipients, among whom were 36 men (78.3%); the average age of recipients was
D. A. Velikiy +5 more
doaj +1 more source
The TreaT-Assay: A Novel Urine-Derived Donor Kidney Cell-Based Assay for Prediction of Kidney Transplantation Outcome [PDF]
Donor-reactive immunity plays a major role in rejection after kidney transplantation, but analysis of donor-reactive T-cells is not applied routinely. However, it has been shown that this could help to identify patients at risk of acute rejection.
Babel, Nina +15 more
core +1 more source
Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection. [PDF]
Consistent with Dr. Paul Terasaki's "humoral theory of rejection" numerous studies have shown that HLA antibodies can cause acute and chronic antibody mediated rejection (AMR) and decreased graft survival. New evidence also supports a role for antibodies
Butler, Carrie L +3 more
core +4 more sources
THE RELATIONSHIP OF QUILTY EFFECT TO ACUTE REJECTION OF THE TRANSPLANTED HEART
Introduction. The Quilty Effect (lymphoid-cellular infiltration of the endocardium) is a frequent finding in biopsies of the transplanted heart. The role of this phenomenon in the rejection of the transplanted heart remains unclear. Aim.
I. M. Iljinsky +6 more
doaj +1 more source
CURRENT VIEW ON MORPHOLOGY OF ACUTE REJECTION IN LIVER TRANSPLANTATION
We present a scientific literature data analysis of morphological features and severity criteria of the liver allograft acute rejection during last 20 years.
L.V. Shkalova +2 more
doaj +1 more source

