Results 31 to 40 of about 197,590 (253)

Expert consensus on the precise classification and diagnosis of acute respiratory distress syndrome

Zhongguo Linchuang Yixue
Acute respiratory distress syndrome (ARDS) is a common critical illness in clinical practice, with a high mortality rate. Given the limited traditional treatment options for ARDS and the high heterogeneity among patients, most clinical trials have failed
Expert Group for Precise Classification and Diagnosis of Acute Respiratory Distress Syndrome
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Trends and advances in Leptospira, a bibliometric analysis

Frontiers in Microbiology
BackgroundLeptospirosis is an acute zoonotic disease caused by pathogenic Leptospira, primarily transmitted to humans through contact with water or soil contaminated by the bacteria.
Wei Wang, Wei Wang, Wei Wang, Yamin Gao, Yamin Gao, Yamin Gao, Jianyu Ji, Jianyu Ji, Jianyu Ji, Zhai Huang, Zhai Huang, Bin Xiong, Bin Xiong, Shulin Xiang, Shulin Xiang   +14 more
doaj   +1 more source

Integrated multi-omics deciphers sepsis immune dysregulation: a dual-pathway targeted small-molecule therapy improves survival and ameliorates multi-organ dysfunction

Frontiers in Immunology
IntroductionSepsis is a life-threatening organ dysfunction syndrome with persistently high global mortality, driven by dysregulated host immune response.
Jiawen Duan, Jiawen Duan, Lingyu Jiang, Kunlin Hu, Huirong Shi, Xinyu Chi, Xinyu Chi, Weiting Feng, Guodong Wang, Shulin Xiang, Shulin Xiang, Bin Xiong, Bin Xiong, Bin Xiong   +13 more
doaj   +1 more source

Simvastatin in the Acute Respiratory Distress Syndrome [PDF]

New England Journal of Medicine, 2014
BACKGROUND Studies in animals and in vitro and phase 2 studies in humans suggest that statins may be beneficial in the treatment of the acute respiratory distress syndrome (ARDS). This study tested the hypothesis that treatment with simvastatin would improve clinical outcomes in patients with ARDS.
McAuley, Daniel F., Laffey, John G., O'Kane, Cecilia M., Perkins, Gavin D., Mullan, Brian, Trinder, T. John, Johnston, Paul, Hopkins, Philip A., Johnston, Andrew J., McDowell, Cliona, McNally, Christine   +10 more
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Linear Association Between Hypoalbuminemia and Increased Risk of Acute Respiratory Distress Syndrome in Critically Ill Adults

Critical Care Explorations, 2021
OBJECTIVES:. We hypothesized that low serum albumin would contribute to pulmonary edema formation, thereby independently increasing the risk of developing acute respiratory distress syndrome in critically ill patients. DESIGN:.
J. Brennan McNeil, MS, Karen E. Jackson, MD, Chunxue Wang, PhD, Edward D. Siew, MD, Andrew J. Vincz, AA, Ciara M. Shaver, MD, PhD, Julie A. Bastarache, MD, Lorraine B. Ware, MD   +7 more
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Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

A novel miRNA biomarker panel associated with mortality in pediatric patients with ARDS

Respiratory Research, 2021
We identified a novel microRNA biomarker panel consisting of 6 microRNAs predicting mortality in pediatric acute respiratory distress syndrome patients.
Lisa K. Lee, Mansoureh Eghbali, Anil Sapru   +2 more
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From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Acute Respiratory Distress Syndrome.

Anesthesiology, 2020
Acute Respiratory Distress Syndrome (ARDS) is defined as the rapid onset of non-cardiogenic pulmonary edema resulting in respiratory failure and hypoxemia. Efforts over the past 25 years, such as those of the ARDS and Prevention and Early Treatment of Acute Lung Injury (PETAL) Networks, have demonstrated a praiseworthy collaboration to further optimize
Williams, George W, Berg, Nathaniel K, Reskallah, Alexander, Yuan, Xiaoyi, Eltzschig, Holger K   +4 more
openaire   +2 more sources