Results 131 to 140 of about 3,524,865 (247)

SARS-CoV Regulates Immune Function-Related Gene Expressions in Human Monocytic Cells [PDF]

, 2011
Background: Severe Acute Respiratory Syndrome (SARS) is characterized by acute respiratory distress (ARDS) and pulmonary fibrosis, and the monocyte/macrophage is the key player in the pathogenesis of SARS. Methods: In this study, we ...
Betty A. Wu-Hsieh, Chuan-Liang Kao, Yu-Ting Yen, Sher Singh, Wan-Jiung(Wan-Chung) Hu   +4 more
core  

Preoperative FIB‐4 Index as a Potential Factor Associated With Severe Postoperative Complications and Endogenous Organ Failure After Hepatectomy for Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, Volume 10, Issue 6, Page 1798-1809, November 2026.
This study demonstrates that a preoperative FIB‐4 index ≥ 5.0 independently predicts severe complications and endogenous organ failure (EOF) following hepatectomy for hepatocellular carcinoma. By capturing structural liver fragility and systemic vulnerability, the FIB‐4 index enhances surgical risk stratification beyond traditional functional markers ...
Masanori Nakamura, Yukiyasu Okamura, Osamu Aramaki, Nao Yoshida, Yusuke Mitsuka, Hayato Abe, Shunsuke Yamagishi, Yasuhiro Okumura, Kyongsun Pak, Shinobu Masuda   +9 more
wiley   +1 more source

Inflammatory Biomarkers as Predictors of In‐Hospital Mortality in Critically Ill COVID‐19 Patients: A Retrospective Cohort Study

Health Science Reports, Volume 9, Issue 11, November 2026.
ABSTRACT Background and Aim Inflammatory biomarkers have been proposed as prognostic indicators in COVID‐19; however, their prognostic associations within critically ill ICU‐admitted patients remain of interest. This study aimed to evaluate the associations of selected inflammatory biomarkers with in‐hospital mortality and their discriminatory ...
Siamak Rimaz, Orchideh Amoie Foumani, Hamid Hoseinzadeh, Mohammad Shokri, Mohammad Haghighi, Mahboobeh Gholipour, Nastaran Najd, Amirhossein Azariyan, Mohammadreza Mobayen, Mahsa Sadeghi   +9 more
wiley   +1 more source

Plasma Interleukin‐10 Levels and IL10 Genetic Variants Are Associated With Clinical Outcomes in Patients With Severe COVID‐19 Treated With Corticosteroids

Journal of Medical Virology, Volume 98, Issue 11, November 2026.
ABSTRACT We aimed to evaluate the association between IL10 variants and plasma IL‐10 levels and clinical outcomes in patients with severe COVID‐19 treated with corticosteroids. We studied 944 patients with severe COVID‐19 who were treated with corticosteroids.
Ingrid Fricke‐Galindo, Francisco M. Ortega‐Villafuerte, Gloria Pérez‐Rubio, Ivette Buendía‐Roldán, Julián Ramírez‐Bello, Azael A. Castillo Morales, Leslie Chávez‐Galán, Rafael de Jesús Hernández‐Zenteno, Espiridión Ramos‐Martínez, Salvador García‐Carmona, Daniela Josefina Cataneo‐Piña, Nora Edith Bautista‐Félix, Ramcés Falfán‐Valencia   +12 more
wiley   +1 more source

Role of gut microbes in acute lung injury/acute respiratory distress syndrome

Gut Microbes
Acute lung injury (ALI) is an acute, diffuse inflammatory lung condition triggered by factors of severe infections, trauma, shock, burns, ischemia-reperfusion, and mechanical ventilation.
Zixuan Ren, Zhihuan Zheng, Xiujing Feng
doaj   +1 more source

Inhaled Nanomedicines for Lung Diseases and Injuries: Pharmacological Advances and Clinical Translation

MedComm, Volume 7, Issue 11, November 2026.
Graphical overview of bioinspired regenerative platforms designed to remodel the diseased lung microenvironment. These systems integrate gene addition, siRNA‐mediated transcript silencing, CRISPR‐based modulation, and base editing approaches to promote alveolar repair, AT2‐to‐AT1 regeneration, resolution of inflammation, and restoration of vascular ...
Kajal Kamra, Sonal Gaur, Jaswinder Singh
wiley   +1 more source

Sepsis: Epidemiology, Pathophysiology, and Management

MedComm, Volume 7, Issue 11, November 2026.
Sepsis remains a major global health burden characterized by substantial geographical heterogeneity and a considerable disease burden in China. Its pathophysiology reflects an interconnected network involving excessive inflammation, oxidative stress, immune imbalance and immunoparalysis, mitochondrial damage, endothelial injury, gut dysbiosis ...
Guang‐Tao Pan, Yu Deng, Lin‐Rui Ma, Yu‐Tong Li, Yu Qian, Yi‐Hua Ma, Hai‐Wei Rao, Yi‐Zhun Zhu, Pei‐Yu Yan   +8 more
wiley   +1 more source

Acute heart failure syndrome [PDF]

, 2015
Keywords: acute heart failure syndrome, acute coronary syndrome, adult respiratory distress syndrome ...
Ker, JA
core  

The PIEZO1/CISD1/IP3R Mechanotransduction Axis Drives Macrophage Mitochondrial Dysfunction and Inflammatory Activation in Pulmonary Fibrosis

MedComm, Volume 7, Issue 11, November 2026.
In the pulmonary fibrotic microenvironment, mechanical signals activate PIEZO1 to mediate Ca2+ entry into macrophages. Increased CISD1/IP3R activity promotes Ca2+ transfer from the endoplasmic reticulum to mitochondria, leading to mitochondrial Ca2+ overload and opening of the mitochondrial permeability transition pore (MPTP). Consequently, macrophages
Yungeng Wei, Chao Xie, Xiangsheng Yang, Xiao Xiao Tang   +3 more
wiley   +1 more source

Adipose‐Derived Mesenchymal Stem Cells: Isolation, Origin, Phenotype Applications, and Challenges

MedComm, Volume 7, Issue 11, November 2026.
Bridging basic biology to clinical translation, this review systematically explores the in vivo origins and evolving isolation techniques of AD‐MSCs. We dissect their diverse phenotype applications orchestrated by immunometabolic reprogramming, mitochondrial transfer, and extracellular vesicles.
Ziyang Liu, Guangming Tu, Chao Wang, Hongyan Zhao, Ziyi Wu, Wei Li, Li Chen, Bailin Niu   +7 more
wiley   +1 more source