Results 111 to 120 of about 4,233,860 (301)

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source

Respiratory muscle dysfunction in acute and chronic respiratory failure: how to diagnose and how to treat? [PDF]

Assessing and treating respiratory muscle dysfunction is crucial for patients with both acute and chronic respiratory failure. Respiratory muscle dysfunction can contribute to the onset of respiratory failure and may also worsen due to interventions ...
Diego Poddighe, Greet Hermans, Marine Van Hollebeke, Rik Gosselink, Dries Testelmans, Alexandros Kalkanis, Beatrix Clerckx, Ghislaine Gayan-Ramirez, Daniel Langer, Antenor Rodrigues, Testelmans, Dries, Clerckx, Beatrix, Rodrigues, Antenor, Van Hollebeke, Marine, Kalkanis, Alexandros, Poddighe, Diego, Langer, Daniel, Gosselink, Rik, Hermans, Greet, Gayan-Ramirez, Ghislaine   +19 more
core   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Influence of vaccination on critical COVID-19 patients with acute respiratory failure: a retrospective cohort study

European Journal of Medical Research
Background Despite vaccines’ effectiveness in reducing COVID-19 infection rates and disease severity, their impact on critical patients presenting with acute respiratory failure is elusive.
Hsiao-Chin Shen, Jhong-Ru Huang, Chuan-Yen Sun, Ying-Ting Liao, Hung-Jui Ko, Chih-Jung Chang, Jia-Yih Feng, Yuh-Min Chen, Wei-Chih Chen, Kuang-Yao Yang   +9 more
doaj   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Neural Fields for Highly Accelerated 2D Cine Phase Contrast MRI

Advanced Science, EarlyView.
ABSTRACT 2D cine phase contrast (CPC) MRI provides quantitative information on blood velocity and flow within the human vasculature. However, data acquisition is time‐consuming, motivating the reconstruction of the velocity field from undersampled measurements to reduce scan times. In this work, neural fields are proposed as a continuous spatiotemporal
Pablo Arratia, Martin J. Graves, Mary McLean, Carolin Pirkl, Carola‐Bibiane Schönlieb, Timo Schirmer, Florian Wiesinger, Matthias J. Ehrhardt   +7 more
wiley   +1 more source

Role of Respiratory Viruses in Severe Acute Respiratory Failure

Respiratory viruses are widespread in the community, affecting both the upper and lower respiratory tract. This review provides an updated synthesis of the epidemiology, pathophysiology, clinical impact, and management of severe respiratory viral ...
Mokrani, David, Timsit, Jean-François, Jean-François Timsit, David Mokrani   +3 more
core   +1 more source

Markers of poor outcome in patients with acute hypoxemic respiratory failure

, 2018
Acute respiratory failure; ARDS ...
이진화
core   +1 more source

Acute Respiratory Failure

Surgical Clinics of North America, 1983
R H, Demling, M, Nerlich
openaire   +4 more sources

Noninvasive Oxygenation in Patients with Acute Respiratory Failure: Current Perspectives

International Journal of General Medicine, 2022
Jean-Pierre Frat,1,2 Sylvain Le Pape,1 Rémi Coudroy,1,2 Arnaud W Thille1,2 1Centre Hospitalier Universitaire de Poitiers, Médecine Intensive Réanimation, Poitiers, France; 2Centre d’Investigation Clinique 1402 ALIVE, INSERM ...
Frat JP, Le Pape S, Coudroy R, Thille AW
doaj