Results 131 to 140 of about 4,233,860 (301)

Oxygen therapy in respiratory disorders [PDF]

, 2012
PhDOxygen therapy remains a cornerstone of medical practice and is generally regarded as being safe. However, there is a lack of clinical evidence to support the routine use of oxygen therapy, and in certain conditions, injudicious oxygen may cause harm.
Wijesinghe, Meme
core   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Noninvasive Ventilation in Acute Respiratory Failure

, 2008
Noninvasive ventilation in acute respiratory failure Respiratory failure is defined as a failure to maintain adequate gas exchange and is characterized by abnormalities of arterial blood gas tensions.
Cicek, Muslum
core  

Epidemiological and genetic analysis of severe acute respiratory syndrome.

, 2004
The severe acute respiratory syndrome (SARS) epidemics in 2002-2003 showed how quickly a novel infectious disease can spread both within communities and internationally.
Fisher, Matthew C, Donnelly, CA, Fisher, MC, Ghani, Azra C, Anderson, Roy M, Ferguson, NM, Riley, Steven, Ghani, AC, Anderson, RM, Donnelly, Christl A, Riley, S, Ferguson, Neil M, Fraser, C, Fraser, Christophe   +13 more
core   +1 more source

A Monolithic Janus Hydrogel Pressure Sensor for Wearable Motion and Physiological Monitoring

Advanced Science, EarlyView.
This work reports a monolithic Janus hydrogel pressure sensor featuring integrated conductive PEDOT and insulating PEGDA layers. The fabricated device achieves a rapid response time, a wide operating range, and good cyclic durability. The sensor demonstrates robust performance in tracking dynamic human joint motions, offering a scalable strategy for ...
Syed Atif Ali, Zeeshan Alam Ansari, Reynaldo Carlos Kuizon Montalbo, Hailemichael Ayalew, Yu‐Sheng Hsiao, Chih‐Wei Chu, Hsiao‐hua Yu, Hsiung‐Lin Tu   +7 more
wiley   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Acute respiratory failure in the elderly.

Critical care (London, England), 2006
With the current epidemiology of a growing advanced-age population and the specificities of critical illness in elderly patients, studies on this topic are appropriate. We need more clinical trials and evaluations of diagnostic and management procedures applied in the elderly, as well as studies designed to identify prognostic factors for inhospital ...
openaire   +2 more sources

Modification‐Selective Inhibition of Succinate Dehydrogenase a Enables Tumor‐Restricted Mitochondrial Modulation

Advanced Science, EarlyView.
This work identifies acetylation‐dependent SDHA homeostasis as a determinant of tumor‐specific metabolic vulnerability. Guided by this mechanism, a modification‐selective inhibitor, ZPI‐3, selectively targets non‐acetylated SDHA, achieving tumor‐restricted SDH inhibition and effective bladder cancer control. Differential responses in clinical specimens
Kaikai Xu, Lulu Kong, Kebin Ye, Xinlu Bao, Haowen Liu, Ning Wang, Yongming Deng, Wei Wang, Shaohua Wei, Lin Zhou   +9 more
wiley   +1 more source

Noninvasive ventilation in acute respiratory failure

, 2007
BACKGROUND: Noninvasive ventilation has assumed an important role in the management of respiratory failure in critical care units, but it must be used selectively depending on the patient's diagnosis and clinical characteristics.
Hill, Nicholas S, NAVA, STEFANO, Brennan, John, Garpestad, Erik   +3 more
core   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source