Results 181 to 190 of about 1,512,759 (352)
Advanced Science, EarlyView.This study identifies TRIM47 as a key driver of liver cancer progression by promoting glycolysis through ubiquitin‐mediated degradation of the gluconeogenic enzyme FBP1. TRIM47 enhances glucose uptake, lactate and ATP production, and tumor growth and metastasis.
Weijie Sun +17 more
wiley +1 more source
Advanced Science, EarlyView.Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann +26 more
wiley +1 more source
Advanced Science, EarlyView.This study demonstrates that HDAC1/2 knockout in microglia alleviates neurological deficits, preserves white matter, and accelerates hematoma clearance after ICH. HDAC1/2 inhibition reduces HK2 acetylation, shifts metabolism from glycolysis to fatty acid oxidation, reduces inflammation, and enhances phagocytosis.
Zhiwen Jiang +9 more
wiley +1 more source
Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections.
Cochrane Database of Systematic Reviews, 2017 P. Schuetz +40 more
semanticscholar +1 more source
Advanced Science, EarlyView.A series of vancomycin‐antimicrobial peptide conjugates is synthesized and evaluated to identify the optimal combination. Vm‐MSI, selected from multiple candidates, exhibited potent activity against vancomycin‐resistant and Gram‐negative bacteria by disrupting membranes and inducing oxidative stress, thereby expanding vancomycin's antibacterial ...
Shuangyu Li +7 more
wiley +1 more source
Advanced Science, EarlyView.Acute brain injuries are characterized by extensive tissue damage, resulting in debilitating deficits in patients. Despite considerable progress, cell‐based approaches have yet to identify an ideal candidate. This long‐term study explores the use of an untested cell source – human enteric glia – and a non‐invasive administration route – intranasal ...
Nina Colitti +11 more
wiley +1 more source
Pharmacotherapy of acute respiratory viral infections
Терапевтический архив, 2013 The paper deals with the etiology, diagnosis, and treatment of acute respiratory viral infections (ARVI). It considers the currently available methods of etiotropic treatment and the tactics of antiviral therapy.
A A Zaĭtsev
doaj
[Hospital acute respiratory infections].
Revista chilena de pediatria, 1991 To study the incidence of nosocomial respiratory tract infection along the first week after admission, 31 children under 2 years of age admitted to the pediatric wards of a general hospital at Metropolitan Santiago, Chile, with the diagnosis of lower respiratory tract infection, were studied for viral agents by immunofluorescence tests, viral isolation
M I, Almarza +5 more
openaire +1 more source
NFS1 Regulates IDH2 to Attenuate Abdominal Aortic Aneurysms via Interacting With SP2
Advanced Science, EarlyView.The loss of NFS1 leads to its reduced binding with the transcription factor SP2, resulting in decreased expression of the downstream gene Idh2. This causes a shift in energy supply toward glycolysis in VSMCs, ultimately contributing to the occurrence and progression of AAA.
Luzheng Zhang +9 more
wiley +1 more source