Results 81 to 90 of about 36,344 (217)

Association of Elevated C‐Reactive Protein in Term Newborns With Neonatal Factors and Gut Microbiota

Acta Paediatrica, EarlyView.
ABSTRACT Aim Plasma C‐reactive protein (CRP) is widely used to assess neonatal infection, although mild, unexplained elevations are common in healthy newborns. We examined relationships between non‐infectious CRP levels and neonatal factors, and early gut microbiota composition in term infants.
Susanna Gardemeister, Aki Saarikivi, Samuli Rautava, Jani Mälkönen, Willem M. de Vos, Katri Korpela, Kaija‐Leena Kolho   +6 more
wiley   +1 more source

Dissolving polymeric microneedle arrays for enhanced site-specific acyclovir delivery

, 2018
Acyclovir is widely indicated for the treatment of herpes labialis (cold sores), typically caused by the herpes simplex virus type 1 (HSV-1). However, topical acyclovir has poor efficacy, due to its low skin permeability.
Tanasait Ngawhirunpat, McCarthy, Helen O; id_orcid, Ryan F. Donnelly, Tekko, Ismaiel A, Vora, Lalitkumar; id_orcid, Boonnada Pamornpathomkul, Pamornpathomkul, Boonnada, Ismaiel A. Tekko, Ngawhirunpat, Tanasait, Lalitkumar Vora, Helen O. McCarthy, Donnelly, Ryan F; id_orcid   +11 more
core   +1 more source

Plasma EC90 multiples are drug, target site and species specific—A physiologically based pharmacokinetic modelling example of nirmatrelvir central nervous system distribution

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Achieving minimum unbound drug concentration in plasma above in vitro EC90 is a common antiviral pharmacokinetic/pharmacodynamic (PK/PD) target. However, it often overlooks restricted distribution into target sites like the central nervous system (CNS), where a trough concentration above 1 × EC90 is needed.
Daan W. van Valkengoed, Xuanlin Liu, Sean N. Avedissian, Courtney V. Fletcher, Ashley N. Brown, Elizabeth C. M. de Lange, Anne‐Grete Märtson   +6 more
wiley   +1 more source

Acyclovir: Voltammetric behaviour and analytical application to pharmaceutical forms [PDF]

, 1996
The electrochemical oxidation of acyclovir at different pH and concentrations using both differential pulse and cyclic voltammetry was studied. Acyclovir exhibits one differential pulse voltammetric peak at the glassy carbon electrode.
Álvarez Lueje, Alejandro, Squella Serrano, Juan, Núñez Vergara, Luis, Vicuna,   +3 more
core  

Acyclovir-induced sinus bradycardia: a case report and literature review [PDF]

Encephalitis
In this report, we describe the case of a 51-year-old female who presented to our emergency department with varicella zoster infection. Her relevant medical history included rheumatoid arthritis which was treated with risankizumab.
Gregory Mikerov, Ilyse Darwish, Gail Goldman   +2 more
doaj   +1 more source

Management of Non‐Plaque‐Induced Gingival Conditions: A Systematic Review—Part 2: Inflammatory and Immune Conditions; Neoplasms; and Gingival Pigmentation

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aims This systematic review assesses current evidence on the management of non‐plaque (dental biofilm)‐induced gingival diseases and conditions (NPIGDs), including (i) inflammatory and immune conditions, (ii) neoplasms and (iii) gingival pigmentations.
Maria Clotilde Carra, Cecile Wasielewski, Bruno Špiljak, Maja Sabalić‐Schoener, Sebastien Jungo, Ivan Alajbeg   +5 more
wiley   +1 more source

Acute kidney injury due to acyclovir

, 2013
Acyclovir is an antiviral agent widely used in herpetic infections in children. Although acyclovir is generally well tolerated, severe nephrotoxicity has been reported in some cases. In this report, we present a 16-year-old girl who developed acute renal
TOPALOĞLU, REZAN, ÖZSÜREKCİ, YASEMİN, CENGİZ, ALİ BÜLENT, Yildiz, Cigdem, Gucer, Safak   +4 more
core   +1 more source

Ruxolitinib cream in adults with moderate atopic dermatitis after failure of other topicals: A randomized trial

Journal of the European Academy of Dermatology and Venereology, EarlyView.
In adults with moderate AD post‐TCS and ‐TCI, who may otherwise be eligible for systemic therapy, 1.5% ruxolitinib cream improved clinical signs and symptoms in the TRuE‐AD4 study. Abstract Background In patients with moderate atopic dermatitis (AD), topical corticosteroids (TCS) and topical calcineurin inhibitors (TCI) often do not sufficiently ...
José Manuel Carrascosa, Vimal H. Prajapati, H. Chih‐ho Hong, Viktoria Eleftheriadou, Athanasios Tsianakas, Alexander A. Navarini, Ketty Peris, Eingun James Song, Raj Chovatiya, Sébastien Barbarot, Konstantin Popovic, Haq Nawaz, Qian Li, Vivek Purohit, Andreas Wollenberg   +14 more
wiley   +1 more source

Acyclovir-related kidney injury during alemtuzumab infusion

, 2015
Acyclovir-related kidney injury during alemtuzumab ...
Bianco, Assunta, Gambaro, Giovanni, Bianco Assunta, Gambaro Giovanni, Rossini, Paolo Maria, Rossini Paolo Maria, Bianco, A, Mirabella, Massimiliano, Mirabella Massimiliano   +8 more
core   +1 more source

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source