Results 71 to 80 of about 36,344 (217)

Exposure to Structurally Related Organophosphate Esters Elicits Distinct Metabolomic Perturbations in Daphnia magna

Environmental Toxicology, EarlyView.
ABSTRACT Organophosphate esters (OPEs) are found ubiquitously in the environment and exposure to these chemicals has induced behavioral, developmental, and morphological impairments in several model organisms. Yet there is still a lack of understanding of how sub‐lethal exposure disrupts organism function at the molecular‐level, especially for Daphnia ...
Salwa Hajir, Sanam Yousifie, Karl J. Jobst, André J. Simpson, Myrna J. Simpson   +4 more
wiley   +1 more source

Prevalence of HCMV, HHV‐6, and HSV‐1/2 in the semen of men attending infertility clinics and their association with semen parameters

UroPrecision, EarlyView.
Abstract Background Viral infections have been identified as potential disruptors of male reproductive health. This study aimed to investigate the prevalence of human cytomegalovirus (HCMV), human herpesvirus 6 (HHV‐6), and herpes simplex virus types 1 and 2 (HSV‐1/2) DNA in semen samples from fertile and infertile men within the potential impact of ...
Seyedeh Zahra Hashemi, Neda Pirbonyeh, Fahime Edalat, Narges Eslami, Saeed Tajik, Arash Letafati, Jamal Sarvari, Afagh Moattari   +7 more
wiley   +1 more source

Acyclovir Nephrotoxicity: A Case Report Highlighting the Importance of Prevention, Detection, and Treatment of Acyclovir-Induced Nephropathy

Case Reports in Medicine, 2010
Acute kidney injury is an unfortunate complication of acyclovir therapy secondary to crystal-induced nephropathy. It is characterized by a decrease in renal function that develops within 24–48 hours of acyclovir administration indicated by a rapid rise ...
Raymond Fleischer, Michael Johnson
doaj   +1 more source

Amenamevir Transfer into Breast Milk in Patients with Herpes Simplex Virus Infection: A Brief Report of a Prospective Multicenter Study

The Journal of Dermatology, EarlyView.
ABSTRACT Patient–initiated therapy (PIT) is a treatment approach in which patients with recurrent herpes simplex self–administer medication at the onset of prodromal symptoms. PIT, which allows patients to receive medication in advance and initiate treatment at any time, is a therapeutic approach that alleviates the burden of urgent clinic visits for ...
Sachi Koinuma, Mikako Goto, Jumpei Saito, Hiroaki Aoki, Satoshi Hayashi, Tomoyoshi Takeshita   +5 more
wiley   +1 more source

Increased Acyclovir Oral Bioavailability via a Bile Acid Conjugate

, 2016
The objective of this work was to design an acyclovir prodrug that would utilize the human apical sodium-dependent bile acid transporter (hASBT) and enhance acyclovir oral bioavailability.
James E. Polli (1317810), Sanna Tolle-Sander (2727400), Dean Y. Maeda (2727403), Kimberley A. Lentz (2012935), Andrew Coop (1416964)   +4 more
core   +1 more source

The effects of oral Acyclovir in the treatment of necrotizing Herpetic keratouveitis [PDF]

Acta Medica Iranica, 2000
This study was conducted to evaluate the effects of administering oral acyclovir in conjunction with topical acyclovir and steroids in the treatment of necrotizing herpetic keratouveitis.
"Hosseini Tehrani M;Poormostadam B;Vallaei N;Raiszadeh F "
doaj   +1 more source

Improvement of physicochemical parameters of acyclovir using cocrystallization approach

Brazilian Journal of Pharmaceutical Sciences
Acyclovir is an antiviral drug having potent activity against the virus of herpes family and varicella zoster. Unfortunately, drug suffers very poor oral bioavailability (15-30%).
Jignasa Ketan Savjani, Chirag Pathak
doaj   +1 more source

The use of nerve growth factor in herpetic keratitis: a case report

Journal of Medical Case Reports, 2007
Background We evaluate the role of nerve growth factor (NGF) eye drops to treat a herpetic corneal ulcer resistant to systemic and local acyclovir treatment in an HIV-positive patient.
Cellini Mauro, Leonetti Pietro, Campos Emilio C   +2 more
doaj   +1 more source

Myeloablative Busulfan, Fludarabine and Melphalan Conditioning for Allogeneic Hematopoietic Stem Cell Transplantation in Childhood Myeloid Malignancy

Asia-Pacific Journal of Clinical Oncology, EarlyView.
We report our single‐center experience of transplant outcomes with a busulfan, fludarabine and melphalan‐based conditioning regimen for children < 18 years of age. The regimen was shown to be well tolerated and effective for heavily pretreated children with high‐risk myeloid malignancies prior to allogeneic hematopoietic stem cell transplant.
Mayank Dhamija, Fiona Kerr, Hazel Gough, Johnathan Soggee, Laurence C. Cheung, Rishi S. Kotecha, Shanti Ramachandran   +6 more
wiley   +1 more source

Crystal structure and supramolecular assembly of the ionic liquid-like salt tributylmethylammonium acyclovir ([N4,4,4,1][Acy])

Journal of Ionic Liquids
In search of low melting, ionic liquid-like forms of the active pharmaceutical ingredient (API), acyclovir, we isolated tributylmethylammonium acyclovir ([N4,4,4,1][Acy]) and structurally characterized it by single crystal X-ray diffraction.
Sophia L. Sagala, Julia L. Shamshina, Robin D. Rogers   +2 more
doaj   +1 more source