Results 11 to 20 of about 826 (83)

Diastereoselective, Diversifiable Synthesis and Biological Evaluation of the Virginiamycin Inducers, the Virginiae Butanolides. [PDF]

Chembiochem
Production of natural products is tightly regulated, resulting in many silent biosynthetic gene clusters. BarA is a repressor that downregulates production of the virginiamycin antibiotics. The VBs are ligands for BarA that reverse its repression of virginiamycin production.
Castator KG, Frias-Gomez M, Wilbanks LE, Parkinson EI.   +3 more
europepmc   +2 more sources

Thiotemplated Polyketide Chain Fusion and Reductive Cyclization Build the Reactive Butenolide Core of Malleicyprol. [PDF]

Angew Chem Int Ed Engl
Malleicyprol, a virulence factor of notorious animal and human pathogens of the Burkholderia pseudomallei (BP) group, results from the fusion of two individual polyketide chains. The noncanonical condensation domain of the PKS–NRPS hybrid synthetase BurF forms an ester bond, and the terminal reductase domain mediates a reductive chain release followed ...
Fiedler J, Dumjahn L, Ishida-Ito M, Trottmann F, Ishida K, Hertweck C.   +5 more
europepmc   +3 more sources

Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications

Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.
The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff, Jemma Arakelyan, Billy Wai‐Lung Ng   +2 more
wiley   +1 more source

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, Volume 4, Issue 2, March 2026.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source

Recent Contributions of Organic Synthesis to Forensic Science

ChemPlusChem, Volume 91, Issue 2, February 2026.
Forensic science is a multidisciplinary field that plays a vital role in providing scientific evidence for criminal investigations. This review highlights advances and opportunities at the interface between organic synthesis and forensic science, with applications in drug identification, forensic toxicology, and latent fingerprint detection and ...
Gustavo dos Santos Martins, Mariana dos Santos Dupim, Rodrigo Garcia Agostinho, Fernanda Gadini Finelli   +3 more
wiley   +1 more source

Natural Products Inhibit Bacterial Growth and Modulate Quorum‐Sensing Systems Las and Rhl in Pseudomonas aeruginosa PA14

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Quorum sensing (QS) is a bacterial cell communication system in Pseudomonas aeruginosa, which regulates the production of several virulence factors, including pyocyanin, exoproteases, and biofilm formation. Natural products (NPs) have demonstrated their ability to control QS in different bacteria. This work evaluated the antimicrobial and anti‐
Oswaldo Pablo Martínez‐Rodríguez, Rodolfo García‐Contreras, Rodrigo Aguayo‐Ortiz, Itzel Rubí Yeverino, Carlos A. Fajardo‐Hernández, Albert D. Patiño, Hugo A. Hernández Pérez, Mariel Hernández‐Garnica, Mario Figueroa   +8 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Jörg Striessnig, Alasdair J. Gibb, Alistair A. Mathie, Emma L. Veale, Eamonn Kelly, Chloe J. Peach, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, David J. Beech, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Han Chow Chua, Alex C. Conner, Henry Danahay, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Wei Fang, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, George K. Chandy, Mohammad‐Reza Ghovanloo, Steve A. N. Goldstein, Martin Gosling, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Tim G. Hales, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Rian W. Manville, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Pérez‐Reyes, Leigh D. Plant, Stephan A. Pless, Lachlan D. Rash, Dejian Ren, Hussein N. Rubaiy, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Paolo Tammaro, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Paola Vergani, Joris Vriens, Stephen G. Waxman, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +86 more
wiley   +1 more source

β‐Amino Acid Synthesis Using the CO2 Radical Anion under Electrochemical and Photochemical Conditions

ChemistryEurope, Volume 3, Issue 6, November 11, 2025.
The development of sustainable methods for synthesizing β‐ and γ‐amino acids is crucial due to their significance in pharmaceuticals and materials science. This study introduces a novel strategy employing the CO2 radical anion as a key intermediate to access these amino acids from N‐Ac‐enamides and N‐Ac‐allylamines.
Tavinder Singh, Yamato Ueno, Kosaku Tanaka III, Wataru Kanna, Yu Harabuchi, Satoshi Maeda, Tsuyoshi Mita   +6 more
wiley   +1 more source

Unlocking Lactonase Enzymes as Biocatalysts for the Deracemisation of Chiral γ‐Thiolactones

Angewandte Chemie, Volume 137, Issue 29, July 14, 2025.
The application of lactonase enzymes as biocatalysts still remains underexplored. This study discloses the biocatalytic activity of two lactonases in the deracemisation of chiral C3‐substituted‐γ‐thiolactones. The biocatalyst GcL catalyses the enzymatic kinetic resolution (EKR) of C3‐amide‐thiolactones, while the rationally engineered biocatalyst N9 ...
Jingyue Wu, Michele Crotti, Ivan Bassanini, Mahdi Hassankalhori, Erica Elisa Ferrandi, Ferran Sancho, Daniela Monti, Daniele Castagnolo   +7 more
wiley   +2 more sources

Understanding zwitterionic ring‐expansion polymerization through mass spectrometry

Mass Spectrometry Reviews, Volume 44, Issue 6, Page 918-946, November/December 2025.
Abstract Zwitterionic ring‐expansion polymerization (ZREP) is a polymerization method in which a cyclic monomer is converted into a cyclic polymer through a zwitterionic intermediate. In this review, we explored the ZREP of various cyclic polymers and how mass spectrometry assists in identifying the product architectures and understanding their ...
Mahi Ahmad, Scott M. Grayson
wiley   +1 more source