Journal of Lipid Research, 2012 Thioesterase superfamily member 1 (Them1; synonyms acyl-CoA thioesterase 11 and StarD14) is highly expressed in brown adipose tissue and limits energy expenditure in mice. Them1 is a putative fatty acyl-CoA thioesterase that comprises tandem hot dog-fold
Shuxin Han, David E. Cohen
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Structural basis of the activation of TRPV5 channels by long-chain acyl-Coenzyme-A. [PDF]
Nat Commun, 2023 Lee BH +3 more
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Glia, Volume 73, Issue 7, Page 1467-1482, July 2025.Main Points CoPAN affects CoA biosynthesis and leads to iron dyshomeostasis. CoPAN d‐astrocytes show ferroptosis, iron accumulation, senescence, lipid peroxidation, mitochondrial damage and tubulin acetylation loss. Astrocytes recapitulate CoPAN disease.
Anna Cozzi +8 more
wiley +1 more source
The elusive “hunger protein”: an appetite-stimulatory factor that is overabundant in human obesity
Molecular & Cellular Oncology, 2019 Paradoxically, most if not all previously known appetite-stimulatory hormones are downregulated in human obesity, reflecting failing homeostatic circuitries.
José Manuel Bravo-San Pedro +2 more
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Regulation of glucose uptake by muscle. 10. Effects of alloxan-diabetes, starvation, hypophysectomy and adrenalectomy, and of fatty acids, ketone bodies and pyruvate, on the glycerol output and concentrations of free fatty acids, long-chain fatty acyl-coenzyme A, glycerol phosphate and citrate-eyele intermediates in rat heart and diaphragm muscles [PDF]
, 1965 P. B. Garland, P. J. Randle
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Molecular Alterations in Ferroptosis and the Effects of Resveratrol: A Systematic Review
Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 7, July 2025.Ferroptosis is a cell death mechanism characterized by iron overload, accumulation of reactive oxygen species, deficits in glutathione metabolism, lipid peroxidation, and mitochondrial impairments. Resveratrol can prevent or reverse these alterations by chelating iron and upregulating antioxidant defenses. ABSTRACT Ferroptosis is an iron‐dependent cell
Ana Beatriz Dos Santos +4 more
wiley +1 more source
Stem Cell Research, 2022 Multiple acyl-coenzyme A dehydrogenase deficiency (MADD) is an inborn metabolic disorder that affects fatty acid oxidation and the catabolism of branched-chain amino acids, vitamins B and energy metabolism.
Yan Li +6 more
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Multi-Method Quantification of Acetyl-Coenzyme A and Further Acyl-Coenzyme A Species in Normal and Ischemic Rat Liver. [PDF]
Int J Mol Sci, 2023 Tokarska-Schlattner M +14 more
europepmc +1 more source
The Journal of Clinical Pharmacology, Volume 65, Issue 7, Page 850-859, July 2025.Abstract Fenofibrate is contraindicated in patients with advanced hepatic fibrosis due to limited clinical data. We evaluated the pharmacokinetics and safety of fenofibrate in participants with mild hepatic impairment (phase 1 study) or advanced fibrosis due to metabolic‐associated fatty liver disease (MAFLD; phase 2a study).
Islam R. Younis +5 more
wiley +1 more source
Parameters of cholesterol metabolism in the human hepatoma cell line, Hep-G2.
Journal of Lipid Research, 1988 The human hepatoma cell line Hep-G2 has been shown to express the major enzymes of intra- and extracellular cholesterol metabolism. These include lecithin:cholesterol acyltransferase, acyl coenzyme A:cholesterol acyltransferase, 3-hydroxy-3 ...
S K Erickson, P E Fielding
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