Results 121 to 130 of about 57,830 (273)

Late‐Onset Multiple Acyl‐CoA Dehydrogenase Deficiency (MADD): A Case Report With a Complex Biochemical Profile

open access: yesJIMD Reports, Volume 66, Issue 4, July 2025.
ABSTRACT Three clinical entities of multiple acyl‐CoA dehydrogenase deficiency (MADD, OMIM#231680) can be differentiated: two severe neonatal forms and one later‐onset form that can manifest in adulthood. The latter typically presents with muscle‐related symptoms, such as exercise intolerance and muscle weakness, with an increase in all chain‐length ...
Romain Penicaud   +8 more
wiley   +1 more source

Structures of Polyhydroxyalkanoate Synthase PhaC from Aeromonas caviae, Producing Biodegradable Plastics

open access: yesAngewandte Chemie, Volume 137, Issue 26, June 24, 2025.
PHA synthase (PhaC) is the key enzyme in the polymerization of a biodegradable plastic—polyhydroxyalkanoate (PHA). Structures of full‐length PhaC reveal three key regions essential for substrate specificity and polymerization. Additionally, this study also highlights the critical role of N‐domain‐dependent dimerization in PhaC activity.
Min Fey Chek   +5 more
wiley   +2 more sources

Identification and characterization of an acyl-CoA:triterpene acyltransferase activity in rabbit and human tissues.

open access: yesJournal of Lipid Research, 1991
Rabbit and human tissues contain substantial amounts of an unusual lipid, a fatty acid ester of a pentacyclic triterpene, that is a potent in vitro inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT). A possible origin of the triterpene ester is via
I Tabas   +6 more
doaj  

Purification and Properties of Long‐Chain Acyl‐Coenzyme‐A Synthetase from Rat Liver [PDF]

open access: bronze, 1979
Takao Tanaka   +3 more
openalex   +1 more source

Oxidative Stress: Signaling Pathways, Biological Functions, and Disease

open access: yesMedComm, Volume 6, Issue 7, July 2025.
Oxidative stress causes cellular damage across multiple systems, contributing to neurodegeneration (Alzheimer's, Parkinson's, Huntington's), cancer progression and resistance, cardiovascular diseases (atherosclerosis, heart failure), liver and kidney injury, metabolic disorders (diabetes, obesity), autoimmune diseases, musculoskeletal decline, retinal ...
Sixuan Liu   +4 more
wiley   +1 more source

Tissue‐Specific Regulation of Fatty Acid Metabolism in a Mouse Model of Isolated Complex I Deficiency

open access: yesPROTEOMICS, Volume 25, Issue 13, July 2025.
ABSTRACT Isolated complex I deficiency (ICD) is commonly associated with mitochondrial diseases and closely mimics subacute necrotising encephalomyelopathy. This disorder is characterised by metabolic perturbations that affect energy metabolism pathways, including fatty acid metabolism.
Sibonelo Glen Khumalo   +2 more
wiley   +1 more source

Targeting Regulation of Macrophage to Treat Metabolic Disease: Role of Phytochemicals

open access: yesCell Proliferation, Volume 58, Issue 7, July 2025.
One‐third of the world's population is affected by metabolic syndrome. Complicated pathogenesis and limited drugs cause the growing prevalence of metabolic syndrome. Macrophage‐mediated metaflammation is closely associated with the development of metabolic syndrome. The role of phytochemicals targeting macrophages in the treatment of metabolic syndrome
Zeting Ye   +6 more
wiley   +1 more source

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