Results 181 to 190 of about 89,018 (342)

Amide and Thioester Synthesis Via Oxidative Coupling of Alcohols with Amines or Thiols Using Alcohol Dehydrogenases

open access: yesAngewandte Chemie, Volume 138, Issue 1, 2 January 2026.
Alcohol dehydrogenases (ADHs) are best known for reducing ketones to chiral alcohols, but their oxidative potential is rarely exploited. Here, we show that selected ADHs catalyze newly discovered promiscuous transformations: the oxidative coupling of primary alcohols with amines or thiols, enabling the direct and efficient synthesis of a broad range of
Matteo Damian   +4 more
wiley   +2 more sources

The Crystal Structure of Human Transport and Golgi Organization 2 Homolog (TANGO2) Protein Reveals an αββα‐Fold Arrangement

open access: yesProteins: Structure, Function, and Bioinformatics, Volume 94, Issue 2, Page 515-528, February 2026.
ABSTRACT Transport and Golgi Organization 2 Homolog (TANGO2) protein deficiency disorder (TDD) is a rare autosomal recessive disorder characterized by multi‐systemic abnormalities and significant phenotypic variability including neurodevelopmental delay, seizures, intermittent ataxia, hypothyroidism, rhabdomyolysis, life‐threatening metabolic ...
Anne Cooper   +6 more
wiley   +1 more source

Comparative lipidomic and proteomic analysis reveals species‐specific differences in midgut composition and insecticide absorption between Apis mellifera and Bombus terrestris

open access: yesPest Management Science, Volume 82, Issue 2, Page 1540-1551, February 2026.
Lipidomic and proteomic analysis revealed large‐scale differences in the midgut composition of the honeybee Apis mellifera and the buff‐tailed bumblebee Bombus terrestris. These differences correlated to increased insecticide absorption in the bumblebee when using an ex vivo Ussing chamber and subsequently in vivo feeding assay (created in Biorender ...
Emmanouil Kokkas   +7 more
wiley   +1 more source

Synechococcus Under Stress: Contrasting Physiological and Transcriptional Responses to Salinity and Temperature in Marine Versus Euryhaline Strains

open access: yesEnvironmental Microbiology Reports, Volume 18, Issue 1, February 2026.
Two model strains of Synechococcus sp.—the marine RS9907 and the euryhaline WH5701—exhibit distinct physiological responses to salinity after long acclimations at optimal and cold growth temperatures. Transcriptomic and photochemical analyses reveal drastic differences in their regulatory strategies and photosynthetic activity across a salinity ...
Isabel Escribano‐Gómez   +6 more
wiley   +1 more source

Characterization of the 5'-flanking regions of arabidopsis acyl-coenzyme a-binding protein1 and acyl-coenzyme a-binding protein2

open access: yes, 2020
In the model plant Arabidopsis thaliana, a gene family of six members encodes acyl-Coenzyme A (CoA)-binding proteins (ACBPs). They are designated as ACBP1 to ACBP6 and they bind to acyl-CoA esters with different affinities. Two membrane-localized members, ACBP1 and ACBP2, share over 70% amino acid identity. Previous studies have shown they are involved
openaire   +1 more source

Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Comprehensive transcriptomic profiling of eight mouse organs across six ages reveals how aging reshapes biological processes. Trajectory and network analyses distinguish shared and organ‐specific signatures, charting the molecular landscape of systemic aging.
Sarah Morsy   +9 more
wiley   +1 more source

Lifespan‐Extending Endogenous Metabolites

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley   +1 more source

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