Results 241 to 250 of about 57,830 (273)

Acyl-Coenzyme A Binding Protein Expression Alters Liver Fatty Acyl-Coenzyme A Metabolism

Biochemistry, 2005
Although studies in vitro and in yeast suggest that acyl-CoA binding protein ACBP may modulate long-chain fatty acyl-CoA (LCFA-CoA) distribution, its physiological function in mammals is unresolved. To address this issue, the effect of ACBP on liver LCFA-CoA pool size, acyl chain composition, distribution, and transacylation into more complex lipids ...
Andrey Frolov, Friedhelm Schroeder, Huan Huang, and Ann B. Kier, Barbara P. Atshaves   +4 more
openaire   +3 more sources

ETFDH Mutations and Flavin Adenine Dinucleotide Homeostasis Disturbance Are Essential for Developing Riboflavin‐Responsive Multiple Acyl–Coenzyme A Dehydrogenation Deficiency

Annals of Neurology, 2018
Riboflavin‐responsive multiple acyl–coenzyme A dehydrogenation deficiency (RR‐MADD) is an inherited fatty acid metabolism disorder mainly caused by genetic defects in electron transfer flavoprotein–ubiquinone oxidoreductase (ETF:QO).
Jingwen Xu, Duoling Li, J. Lv, Xuebi Xu, B. Wen, P. Lin, Fuchen Liu, K. Ji, Jingli Shan, Hong-hao Li, Wei Li, Yuying Zhao, Dandan Zhao, J. Pok, Chuanzhu Yan   +14 more
semanticscholar   +1 more source

Characterization of Lipid Binding Properties of Plasmodium falciparum Acyl-Coenzyme A Binding Proteins and Their Competitive Inhibition by Mefloquine.

ACS Chemical Biology, 2019
Malaria remains a worldwide concern in terms of morbidity and mortality. Limited understanding of the Plasmodium proteome makes it challenging to control malaria. Understanding of the expression and functions of different Plasmodium proteins will help in
Abhishek Kumar, D. Ghosh, Jamshaid Ali, A. Ranjan   +3 more
semanticscholar   +1 more source

Inhibitors of Acyl-Coenzyme A: Cholesterol Acyltransferase

Current Drug Target -Cardiovascular & Hematological Disorders, 2005
Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that catalyzes the formation of cholesterol esters from cholesterol and fatty acyl-coenzyme A. Animal experiments showed that ACAT inhibitors reduce plasma cholesterol levels by suppressing absorption of dietary cholesterol and by suppressing the assembly and secretion of ...
Akira Miyazaki, Takuya Watanabe, Tomoko Kanome   +2 more
openaire   +3 more sources

Sensor for free fatty acids based on acyl coenzyme-a synthetase and acyl coenzyme-a oxidase

Analytica Chimica Acta, 1989
Abstract The measurement is based on monitoring dissolved oxgyen consumed by the two sequential reactions catalyzed by the enzymes immobilized in photo-cross-linkable poly (vinyl alcohol) resin (PVA-SbQ). A linear correlation was observed between current decrease and 0.3–2.6 mM oleic or palmitic acid.
Yuko Kameda, Eiichi Tamiya, Koji Sode, Isao Karube   +3 more
openaire   +2 more sources

[9] Preparation of radioactive acyl coenzyme A

1986
Publisher Summary This chapter discusses the preparation of radioactive acyl coenzyme A. In this procedure, long-chain 14 C-labeled fatty acid is first converted to the acyl chloride by oxalyl chloride, which is then condensed with CoASH to form the corresponding long-chain acyl-CoA.
Amiya K. Hajra, James Bishop
openaire   +3 more sources

Comprehensive Analysis of Short-, Medium-, and Long-Chain Acyl-Coenzyme A by Online Two-Dimensional Liquid Chromatography/Mass Spectrometry.

Analytical Chemistry, 2017
Acyl-coenzyme A (CoA) is a pivotal metabolic intermediate in numerous biological processes. However, comprehensive analysis of acyl-CoAs is still challenging as the properties of acyl-CoAs greatly vary with different carbon chains.
Shuangyuan Wang, Zhichao Wang, Lina Zhou, Xianzhe Shi, Guowang Xu   +4 more
semanticscholar   +1 more source

Fatty Acyl-Coenzyme A Dehydrogenases

Biochemical Society Transactions, 1978
The general enzymology of @-oxidation has suffered extraordinary neglect since the broad outlines of the pathway were established in the 1950’s. For the acyl-CoA dehydrogenases the contributions from the Institute for Enzyme Research at the University of Wisconsin still represent the major part of our knowledge.
openaire   +3 more sources

Acyl-coenzyme A: cholesterol acyltransferase family

Frontiers of Biology in China, 2008
The enzymes of the acyl-coenzyme A: cholesterol acyltransferase (ACAT) family are responsible for the in vivo synthesis of neutral lipids. They are potential drug targets for the intervention of atherosclerosis, hyperlipidemia, obesity, type II diabetes and even Alzheimer’s disease.
Zhanyun Guo, Yali Liu
openaire   +2 more sources

Hereditary and acquired diseases of acyl-coenzyme A metabolism

Molecular Genetics and Metabolism, 2008
Coenzyme A (CoA) sequestration, toxicity or redistribution (CASTOR) is predicted to occur in many hereditary and acquired conditions in which the degradation of organic acyl esters of CoA is impaired. The resulting accumulation of CoA esters and reduction of acetyl-CoA and free CoA (CoASH) will then trigger a cascade of reactions leading to clinical ...
Grant A. Mitchell, Nicolas Gauthier, Ijaz A. Qureshi, Alain Lesimple, Shu Pei Wang, Orval A. Mamer   +5 more
openaire   +3 more sources