Results 21 to 30 of about 57,830 (273)

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

An acyl-CoA synthetase in Mycobacterium tuberculosis involved in triacylglycerol accumulation during dormancy. [PDF]

PLoS ONE, 2014
Latent infection with dormant Mycobacterium tuberculosis is one of the major reasons behind the emergence of drug-resistant strains of the pathogen worldwide.
Jaiyanth Daniel, Tatiana Sirakova, Pappachan Kolattukudy   +2 more
doaj   +1 more source

In Search of Small Molecules That Selectively Inhibit MBOAT4

Molecules, 2021
Ghrelin is a 28-residue peptide hormone produced by stomach P/D1 cells located in oxyntic glands of the fundus mucosa. Post-translational octanoylation of its Ser-3 residue, catalyzed by MBOAT4 (aka ghrelin O-acyl transferase (GOAT)), is essential for ...
Emily S. Murzinski, Ishika Saha, Hui Ding, David Strugatsky, Ryan A. Hollibaugh, Haixia Liu, Peter Tontonoz, Patrick G. Harran   +7 more
doaj   +1 more source

In silico identification of potential inhibitors of acyl carrier protein reductase and acetyl CoA carboxylase of Plasmodium falciparum in antimalarial therapy

Frontiers in Drug Discovery, 2023
Malaria caused by Plasmodium falciparum, remains one of the most fatal parasitic diseases that has affected nearly a third of the world’s population. The major impediment to the treatment of malaria is the emergence of resistance of the P.
Elliasu Y. Salifu, James Abugri, James Abugri, Issahaku A. Rashid, Festus Osei, Joseph Atia Ayariga   +5 more
doaj   +1 more source

Activation of hypolipidaemic drugs to acyl-coenzyme A thioesters [PDF]

Biochemical Journal, 1986
Compounds possessing the characteristics of CoA thioesters of the hypolipidaemic peroxisome proliferators clofibric acid, nafenopin and ciprofibrate were formed on incubation of the drugs with rat liver microsomal fractions, ATP and CoA. The reactivity of the drugs correlated with their pharmacological potency. It is proposed that the active species of
BRONFMAN, M, AMIGO, L, MORALES, MN
openaire   +3 more sources

Proofreading of noncognate acyl adenylates by an acyl-coenzyme a ligase.

Chemistry & Biology, 2013
Aminoacyl-tRNA synthetases remove (proofread) incorrect substrates and thereby prevent errors in protein synthesis. We report enzyme-catalyzed pretransfer editing by pimeloyl-coenzyme A (CoA) ligase (BioW), a biotin synthetic enzyme that converts pimelate, a seven-carbon dicarboxylic acid, to its CoA ester.
Miglena Manandhar, J. Cronan
semanticscholar   +4 more sources

Purification and Characterization of a Novel Pumpkin Short-Chain Acyl-Coenzyme A Oxidase with Structural Similarity to Acyl-Coenzyme A Dehydrogenases [PDF]

Plant Physiology, 2000
Abstract A novel pumpkin (Cucurbita  pepo) short-chain acyl-coenzyme A (CoA) oxidase (ACOX) was purified to homogeneity by hydrophobic-interaction, hydroxyapatite, affinity, and anion-exchange chromatography. The purified enzyme is a tetrameric protein, consisting of apparently identical 47-kD subunits.
DE BELLIS L., GONZALI S., ALPI, AMEDEO, HAYASHI H., HAYASHI M., NISHIMURA M.   +5 more
openaire   +3 more sources

Short-chain acyl-coenzyme A dehydrogenase deficiency [PDF]

Molecular Genetics and Metabolism, 2008
Short-chain acyl-CoA dehydrogenase deficiency (SCADD) is a disorder of mitochondrial fatty acid oxidation that leads to the accumulation of butyrylcarnitine and ethylmalonic acid in blood and urine. Originally described with a relatively severe phenotype, most patients are now diagnosed through newborn screening by tandem mass spectrometry and remain ...
Jerry Vockley, Michael J. Bennett, Reena Jethva   +2 more
openaire   +3 more sources

Characterization of a Bifunctional Archaeal Acyl Coenzyme A Carboxylase [PDF]

Journal of Bacteriology, 2003
ABSTRACT Acyl coenzyme A carboxylase (acyl-CoA carboxylase) was purified from Acidianus brierleyi . The purified enzyme showed a unique subunit structure (three subunits with apparent molecular masses of 62, 59, and 20 kDa) and a molecular mass of approximately 540 kDa, indicating an α 4
Yasuo Igarashi, Hiroyuki Arai, Songkran Chuakrut, Masaharu Ishii   +3 more
openaire   +3 more sources

A universal pocket in fatty acyl-AMP ligases ensures redirection of fatty acid pool away from coenzyme A-based activation

eLife, 2021
Fatty acyl-AMP ligases (FAALs) channelize fatty acids towards biosynthesis of virulent lipids in mycobacteria and other pharmaceutically or ecologically important polyketides and lipopeptides in other microbes.
Gajanan S Patil, Priyadarshan Kinatukara, Sudipta Mondal, Sakshi Shambhavi, Ketan D Patel, Surabhi Pramanik, Noopur Dubey, Subhash Narasimhan, Murali Krishna Madduri, Biswajit Pal, Rajesh S Gokhale, Rajan Sankaranarayanan   +11 more
doaj   +1 more source