Results 31 to 40 of about 57,830 (273)
Circulation, 2019 BACKGROUND Metabolic remodeling in heart failure contributes to dysfunctional lipid trafficking and lipotoxicity. Acyl coenzyme A synthetase-1 (ACSL1) facilitates long-chain fatty acid (LCFA) uptake and activation with coenzyme A (CoA), mediating the ...
J. R. Goldenberg +6 more
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Molecular Basis of KAT2A Selecting Acyl-CoA Cofactors for Histone Modifications
Research, 2023 Emerging discoveries about undocumented acyltransferase activities of known histone acetyltransferases (HATs) advance our understandings in the regulation of histone modifications. However, the molecular basis of HATs selecting acyl coenzyme A (acyl-CoA)
Sha Li +7 more
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Scientific Reports, 2018 Medium-chain acyl-Coenzyme A dehydrogenase (MCAD) is involved in the initial step of mitochondrial fatty acid β-oxidation (FAO). Loss of function results in MCAD deficiency, a disorder that usually presents in childhood with hypoketotic hypoglycemia ...
S. C. Lim +7 more
semanticscholar +1 more source
PLoS Pathogens, 2015 Biotin-mediated carboxylation of short-chain fatty acid coenzyme A esters is a key step in lipid biosynthesis that is carried out by multienzyme complexes to extend fatty acids by one methylene group.
Matthias T Ehebauer +12 more
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Pharmacogenomics and Personalized Medicine, 2023 Xiaoxia Wang, Haining Fang Department of Pediatrics, Maternal and Child Health Hospital of Hubei Province, Wuhan, 430070, People’s Republic of ChinaCorrespondence: Haining Fang, Department of Pediatrics, Maternal and Child Health Hospital of Hubei ...
Wang X, Fang H
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Journal of Biological Chemistry, 1973 Abstract A particulate preparation isolated from Escherichia coli B catalyzes the acylation of 1-acyl-sn-glycerol 3-phosphate (1-acyl-GP) with both oleoyl-CoA and palmitoyl-CoA. The optimum conditions were determined for the acyl-CoA: 1-acyl-GP acyltransferase.
Harumi Okuyama, Salih J. Wakil
openaire +3 more sources
A FRET sensor for the real-time detection of long chain acyl-CoAs and synthetic ABHD5 ligands
Cell Reports: Methods, 2023 Summary: Intracellular long-chain acyl-coenzyme As (LC-acyl-CoAs) are thought to be under tight spatial and temporal controls, yet the ability to image LC-acyl-CoAs in live cells is lacking.
Emilio P. Mottillo +6 more
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Acyl-coenzyme A synthetases in metabolic control
Current Opinion in Lipidology, 2010 The 11 long-chain (ACSL) and very long chain acyl-coenzyme A (acyl-CoA) synthetases [(ACSVL)/fatty acid transport protein] are receiving considerable attention because it has become apparent that their individual functions are not redundant.
Jessica M. Ellis +3 more
openaire +4 more sources
A Single LC-MS/MS Analysis to Quantify CoA Biosynthetic Intermediates and Short-Chain Acyl CoAs
Metabolites, 2021 Coenzyme A (CoA) is an essential cofactor for dozens of reactions in intermediary metabolism. Dysregulation of CoA synthesis or acyl CoA metabolism can result in metabolic or neurodegenerative disease.
Anthony E. Jones +5 more
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PLoS ONE, 2016 Dysregulated lipid metabolism contributes to cancer progression. Our previous study indicates that long-chain fatty acyl-Co A synthetase (ACSL) 3 is essential for lipid upregulation induced by endoplasmic reticulum stress.
Wei-Ching Chen +5 more
semanticscholar +1 more source