Results 41 to 50 of about 89,018 (342)
Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats [PDF]
, 2013 Background: Metabolic syndrome (coexisting visceral obesity, dyslipidemia, hyperglycemia, and hypertension) is a prominent risk factor for cardiovascular morbidity and mortality, however, its effect on cardiac gene expression pattern is unclear ...
Csonka, Csaba +10 more
core +3 more sources
Circulation, 2019 BACKGROUND Metabolic remodeling in heart failure contributes to dysfunctional lipid trafficking and lipotoxicity. Acyl coenzyme A synthetase-1 (ACSL1) facilitates long-chain fatty acid (LCFA) uptake and activation with coenzyme A (CoA), mediating the ...
J. R. Goldenberg +6 more
semanticscholar +1 more source
Acylation of monolysocardiolipin in rat heart
Journal of Lipid Research, 1999 Cardiolipin is a major mitochondrial membrane glycerophospholipid in the mammalian heart. In this study, the ability of the isolated intact rat heart to remodel cardiolipin and the mitochondrial enzyme activities that reacylate monolysocardiolipin to ...
Brian J. Ma +3 more
doaj +1 more source
eLife, 2021 Fatty acyl-AMP ligases (FAALs) channelize fatty acids towards biosynthesis of virulent lipids in mycobacteria and other pharmaceutically or ecologically important polyketides and lipopeptides in other microbes.
Gajanan S Patil +11 more
doaj +1 more source
Characterization of a Bifunctional Archaeal Acyl Coenzyme A Carboxylase [PDF]
Journal of Bacteriology, 2003 ABSTRACT Acyl coenzyme A carboxylase (acyl-CoA carboxylase) was purified from Acidianus brierleyi . The purified enzyme showed a unique subunit structure (three subunits with apparent molecular masses of 62, 59, and 20 kDa) and a molecular mass of approximately 540 kDa, indicating an α 4
Songkran, Chuakrut +3 more
openaire +2 more sources
Biocatalytic Synthesis of Stereospecific Triketide Lactones using Polyketide Synthases [PDF]
, 2016 Polyketide synthases are modular enzymes that create and modify large acyl chains. The domains and modules of polyketide synthases allow us to create molecules that resemble naturally occurring products by applying a biocatalytic in vitro in vivo ...
Alexander, Bradley
core +1 more source
Purification and Characterization of a Novel Pumpkin Short-Chain Acyl-Coenzyme A Oxidase with Structural Similarity to Acyl-Coenzyme A Dehydrogenases [PDF]
Plant Physiology, 2000 Abstract A novel pumpkin (Cucurbita pepo) short-chain acyl-coenzyme A (CoA) oxidase (ACOX) was purified to homogeneity by hydrophobic-interaction, hydroxyapatite, affinity, and anion-exchange chromatography. The purified enzyme is a tetrameric protein, consisting of apparently identical 47-kD subunits.
DE BELLIS L. +5 more
openaire +3 more sources
Saikosaponins induced hepatotoxicity in mice via lipid metabolism dysregulation and oxidative stress: a proteomic study [PDF]
, 2017 Background Radix Bupleuri (RB) has been popularly used for treating many liver diseases such as chronic hepatic inflammation and viral Hepatitis in China.
Huang, Youyi +7 more
core +2 more sources
A minimal biochemical route towards de novo formation of synthetic phospholipid membranes. [PDF]
, 2019 All living cells consist of membrane compartments, which are mainly composed of phospholipids. Phospholipid synthesis is catalyzed by membrane-bound enzymes, which themselves require pre-existing membranes for function.
Bhattacharya, Ahanjit +3 more
core +2 more sources
PLoS Pathogens, 2015 Biotin-mediated carboxylation of short-chain fatty acid coenzyme A esters is a key step in lipid biosynthesis that is carried out by multienzyme complexes to extend fatty acids by one methylene group.
Matthias T Ehebauer +12 more
doaj +1 more source