Results 91 to 100 of about 2,608,587 (304)

Ultrafast polarization-modulation transient spectroscopy to study electronic excited state dynamics in solutions and cells [PDF]

arXiv, 2020
A novel polarization-modulation transient method has been developed for studying fast anisotropic relaxation in electronic excited states of polyatomic and biologically relevant molecules under excitation with femtosecond laser pulses. The method is based on the modulation of pump beam polarization with a photo-elastic modulator and detection of an ...
arxiv  

Metabolism of propionic acid to a novel acyl-coenzyme A thioester by mammalian cell lines and platelets[S]

Journal of Lipid Research, 2015
Metabolism of propionate involves the activated acyl-thioester propionyl-CoA intermediate. We employed LC-MS/MS, LC-selected reaction monitoring/MS, and LC-high-resolution MS to investigate metabolism of propionate to acyl-CoA intermediates.
N. Snyder, Sankha S. Basu, A. Worth, C. Mesaros, I. Blair   +4 more
semanticscholar   +1 more source

Immunolocalization of Acyl-Coenzyme A:CholesterolO-Acyltransferase in Macrophages [PDF]

Journal of Biological Chemistry, 1998
Macrophages in atherosclerotic lesions accumulate large amounts of cholesteryl-fatty acyl esters ("foam cell" formation) through the intracellular esterification of cholesterol by acyl-coenzyme A:cholesterol O-acyltransferase (ACAT). In this study, we sought to determine the subcellular localization of ACAT in macrophages.
Ira Tabas, Robert V. Farese, Nanda Beatini, Hongxing Wang, Ta-Yuan Chang, Frederick R. Maxfield, Vardiella L. Meiner, Xavier Buton, Nadia Khelef   +8 more
openaire   +3 more sources

Sunflower (Helianthus annuus) long-chain acyl-coenzyme A synthetases expressed at high levels in developing seeds.

Physiologia Plantarum : An International Journal for Plant Biology, 2014
Long chain fatty acid synthetases (LACSs) activate the fatty acid chains produced by plastidial de novo biosynthesis to generate acyl-CoA derivatives, important intermediates in lipid metabolism.
Jose A. Aznar-Moreno, Mónica Venegas Calerón, Enrique Martínez-Force, R. Garcés, R. Mullen, S. Gidda, J. Salas   +6 more
semanticscholar   +1 more source

Sirt5 regulates chondrocyte metabolism and osteoarthritis development through protein lysine malonylation

Arthritis &Rheumatology, Accepted Article.
Objectives Chondrocyte metabolic dysfunction plays an important role in osteoarthritis (OA) development during aging and obesity. Protein post‐translational modifications (PTMs) have recently emerged as an important regulator of cellular metabolism. We aim to study one type of PTM, lysine malonylation (MaK) and its regulator Sirt5 in OA development ...
Huanhuan Liu, Anupama Binoy, Siqi Ren, Thomas C. Martino, Anna E. Miller, Craig R. G. Willis, Shivakumar R. Veerabhadraiah, Joanna Bons, Jacob P. Rose, Birgit Schilling, Michael J. Jurynec, Shouan Zhu   +11 more
wiley   +1 more source

First‐in‐human safety, tolerability, pharmacokinetics and pilot food‐effect study of the candidate antimalarial compound MMV367

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim To evaluate the safety, tolerability and pharmacokinetics in healthy participants of orally administered MMV367 (GSK3772701), a novel antimalarial interfering with Plasmodium falciparum acyl coenzyme A synthetase 10/11 function. Methods This first‐in‐human study enrolled 47 healthy male and female participants.
Andrea Kuemmerle, Nand Singh, Denis Gossen, Annick Janin, Raman Sharma, Anthony Cahn, Rachel A. Gibson, Somasekhara R. Menakuru, Erin Lambourne, Tom Dove, Francisco‐Javier Gamo, Laura Sanz, Benoit Bestgen, Stephan Chalon   +13 more
wiley   +1 more source

ETFDH mutation involves excessive apoptosis and neurite outgrowth defect via Bcl2 pathway

Scientific Reports
The most common mutation in southern Chinese individuals with late-onset multiple acyl-coenzyme A dehydrogenase deficiency (MADD; a fatty acid metabolism disorder) is c.250G > A (p.Ala84Thr) in the electron transfer flavoprotein dehydrogenase gene (ETFDH)
Chuang-Yu Lin, Wen-Chen Liang, Yi-Chen Yu, Shin-Cheng Chang, Ming-Chi Lai, Yuh-Jyh Jong   +5 more
doaj   +1 more source

Functions of Coenzyme A and Acyl-CoA in Post-Translational Modification and Human Disease

Frontiers in Bioscience-Landmark
Coenzyme A (CoA) is synthesized from pantothenate, L-cysteine and adenosine triphosphate (ATP), and plays a vital role in diverse physiological processes. Protein acylation is a common post-translational modification (PTM) that modifies protein structure,
Jumin Xie, Zhang Yu, Ying Zhu, Mei Zheng, Yanfang Zhu   +4 more
doaj   +1 more source

An Adjacency Matrix Perspective of Talented Monoids and Leavitt Path Algebras [PDF]

arXiv, 2022
In this article we establish relationships between Leavitt path algebras, talented monoids and the adjacency matrices of the underlying graphs. We show that indeed the adjacency matrix generates in some sense the group action on the generators of the talented monoid.
arxiv  

Shrinking the FadE Proteome of Mycobacterium tuberculosis: Insights into Cholesterol Metabolism through Identification of an α2β2 Heterotetrameric Acyl Coenzyme A Dehydrogenase Family

Journal of Bacteriology, 2013
The ability of the pathogen Mycobacterium tuberculosis to metabolize steroids like cholesterol and the roles that these compounds play in the virulence and pathogenesis of this organism are increasingly evident.
M. Wipperman, Meng Yang, Suzanne T Thomas, N. Sampson   +3 more
semanticscholar   +1 more source