Results 211 to 220 of about 31,319 (243)

ACYL-COENZYME A:CHOLESTEROL ACYLTRANSFERASE

Annual Review of Biochemistry, 1997
Due to its presumed role in regulating cellular cholesterol homeostasis, and in various pathophysiological conditions, acyl-coenzyme A:cholesterol acyltransferase (ACAT) has attracted much attention. Cloning the ACAT gene provides the necessary tool to advance molecular studies of this enzyme.
Catherine C.Y. Chang, Ta-Yuan Chang, Dong Cheng   +2 more
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Acyl coenzyme A dependent retinol esterification by acyl coenzyme A:diacylglycerol acyltransferase 1

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2005
We provide biochemical evidence that enzymes involved in the synthesis of triacylglycerol, namely acyl coenzyme A:diacylglycerol acyltransferase (DGAT) and acyl coenzyme A:monoacylglycerol acyltransferase (MGAT), are capable of carrying out the acyl coenzyme A:retinol acyltransferase (ARAT) reaction.
M. Mahmood Hussain, Jeffrey T. Billheimer, Dong Cheng, Kamran Anwar, Luping Chen, Ching-Hsuen Chu, Michael D. Orland, Debra Cromley   +7 more
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Acyl-coenzyme A binding protein (ACBP)

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1999
Acyl-coenzyme A binding proteins are known from a large group of eukaryote species and to bind a long chain length acyl-CoA ester with very high affinity. Detailed biochemical mapping of ligand binding properties has been obtained as well as in-depth structural studies on the bovine apo-protein and of the complex with palmitoyl-CoA using NMR ...
Kragelund, B.B., Knudsen, J., Poulsen, F.M.   +2 more
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Acyl-coenzyme A

Current Opinion in Lipidology, 1999
In addition to acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT1), an enzyme in the endoplasmic reticulum of cells found ubiquitously throughout the body, data recently obtained in at least three mammalian species, including nonhuman primates, mice and humans, demonstrate the presence of an additional ACAT (EC 2.1.3.26), termed ACAT2, which is ...
Lawrence L. Rudel, Charles Joyce, Kelly A. Skinner, Richard A. Anderson   +3 more
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Acyl-Coenzyme A Binding Protein Expression Alters Liver Fatty Acyl-Coenzyme A Metabolism

Biochemistry, 2005
Although studies in vitro and in yeast suggest that acyl-CoA binding protein ACBP may modulate long-chain fatty acyl-CoA (LCFA-CoA) distribution, its physiological function in mammals is unresolved. To address this issue, the effect of ACBP on liver LCFA-CoA pool size, acyl chain composition, distribution, and transacylation into more complex lipids ...
Andrey Frolov, Friedhelm Schroeder, Huan Huang, and Ann B. Kier, Barbara P. Atshaves   +4 more
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And then there were acyl coenzyme A:cholesterol acyl transferase inhibitors

Current Opinion in Lipidology, 2006
The reputation of acyl coenzyme A:cholesterol acyltransferase (ACAT) inhibitors has changed profoundly from promising new drugs for cardiovascular prevention to drugs without clinical benefits or possibly even with adverse effects.ACAT inhibitors decrease the intracellular conversion of free cholesterol into cholesteryl ester in a number of tissues ...
Erik S.G. Stroes, Marijn C. Meuwese, Remco Franssen, John J.P. Kastelein   +3 more
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Acyl-CoAs from Coenzyme Ribozymes

Biochemistry, 2001
We describe in vitro selection of two novel ribozymes that mediate coenzyme reactions. The first is a trans-capping ribozyme that attaches coenzyme A (CoA) at the 5' end of any RNA with the proper short terminal sequence, including RNAs with randomized internal sequences.
Michael Yarus, Vasant Jadhav
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[9] Preparation of radioactive acyl coenzyme A

1986
Publisher Summary This chapter discusses the preparation of radioactive acyl coenzyme A. In this procedure, long-chain 14 C-labeled fatty acid is first converted to the acyl chloride by oxalyl chloride, which is then condensed with CoASH to form the corresponding long-chain acyl-CoA.
Amiya K. Hajra, James Bishop
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Inhibitors of Acyl-Coenzyme A: Cholesterol Acyltransferase

Current Drug Target -Cardiovascular & Hematological Disorders, 2005
Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that catalyzes the formation of cholesterol esters from cholesterol and fatty acyl-coenzyme A. Animal experiments showed that ACAT inhibitors reduce plasma cholesterol levels by suppressing absorption of dietary cholesterol and by suppressing the assembly and secretion of ...
Akira Miyazaki, Takuya Watanabe, Tomoko Kanome   +2 more
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Fatty Acyl-Coenzyme A Dehydrogenases

Biochemical Society Transactions, 1978
The general enzymology of @-oxidation has suffered extraordinary neglect since the broad outlines of the pathway were established in the 1950’s. For the acyl-CoA dehydrogenases the contributions from the Institute for Enzyme Research at the University of Wisconsin still represent the major part of our knowledge.
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