Results 221 to 230 of about 31,319 (243)
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Sensor for free fatty acids based on acyl coenzyme-a synthetase and acyl coenzyme-a oxidase
Analytica Chimica Acta, 1989Abstract The measurement is based on monitoring dissolved oxgyen consumed by the two sequential reactions catalyzed by the enzymes immobilized in photo-cross-linkable poly (vinyl alcohol) resin (PVA-SbQ). A linear correlation was observed between current decrease and 0.3–2.6 mM oleic or palmitic acid.
Yuko Kameda +3 more
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Biochemical Pharmacology, 1990
Cyclandelate was an effective inhibitor of rat hepatic acycloenzyme A: cholesterol acyltransferase (ACAT) with a concentration of 80 microM being required for half maximal inhibition. A similar effect was seen with human and rabbit liver microsomal enzymes.
Francesca Heffron +2 more
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Cyclandelate was an effective inhibitor of rat hepatic acycloenzyme A: cholesterol acyltransferase (ACAT) with a concentration of 80 microM being required for half maximal inhibition. A similar effect was seen with human and rabbit liver microsomal enzymes.
Francesca Heffron +2 more
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Formation of S-acyl pantetheine from acyl=coenzyme a by plasma membranes
Biochimica et Biophysica Acta (BBA) - Biomembranes, 19681. 1. During incubation of a variety of plasma membrane preparations with S-acyl-CoA esters substantial amounts of a novel lipid were produced. This material was identified as S-acyl pantetheine. 2. 2. Characterization of palmityl pantetheine was achieved by infrared and mass spectrometry, by analysis for its constituent groups and by chemical ...
Janice Robinson +2 more
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Chemical events in chloropropionyl-coenzyme A inactivation of acyl-coenzyme A utilizing enzymes
Biochemistry, 1989Incubation of 3-chloropropionyl-CoA with 3-hydroxy-3-methylglutaryl-CoA synthase results in exchange of the C2 proton with solvent as inactivation of enzyme proceeds. This enzyme is also inhibited by S-acrylyl-N-acetylcysteamine; the limiting rate constant for inactivation by the acrylyl derivative (0.36 min-1) slightly exceeds the value measured for ...
Christine E. Behnke +2 more
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[25] Synthesis of nonhydrolyzable acyl-coenzyme A analogs
1997Publisher Summary This chapter describes the chemical synthesis of different precursors of the nonhydrolyzable acyl–CH2CoA derivatives. The final synthesis of various nonhydrolyzable acyl–CH2CoA derivatives is also described. The activity of pantetheine phosphate adenylyltransferase is assayed in the reverse direction by monitoring the production of ...
Abend, Andreas, Retey, Janos
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Rat Hepatic Coenzyme A is Redistributed in Response to Mitochondrial Acyl-Coenzyme A Accumulation ,
The Journal of Nutrition, 1992Coenzyme A without an acyl-thioester (CoASH) is required for numerous cellular reactions, and sequestration of CoASH as acyl-CoAs may impair metabolic function. Increased total CoA protects the cell from acyl-CoA accumulation, and enhanced CoA biosynthesis may represent a compensatory response in metabolic disease.
Eric P. Brass, Laura J. Ruff
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Acyl-coenzyme A: cholesterol acyltransferase family
Frontiers of Biology in China, 2008The enzymes of the acyl-coenzyme A: cholesterol acyltransferase (ACAT) family are responsible for the in vivo synthesis of neutral lipids. They are potential drug targets for the intervention of atherosclerosis, hyperlipidemia, obesity, type II diabetes and even Alzheimer’s disease.
Zhanyun Guo, Yali Liu
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Hereditary and acquired diseases of acyl-coenzyme A metabolism
Molecular Genetics and Metabolism, 2008Coenzyme A (CoA) sequestration, toxicity or redistribution (CASTOR) is predicted to occur in many hereditary and acquired conditions in which the degradation of organic acyl esters of CoA is impaired. The resulting accumulation of CoA esters and reduction of acetyl-CoA and free CoA (CoASH) will then trigger a cascade of reactions leading to clinical ...
Grant A. Mitchell +5 more
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Multiple acyl-coenzyme A carboxylases in Pseudomonas citronellolis
Biochemistry, 1976Pseudomonas citronellolis was shown to contain four different acyl-coenzyme A carboxylases, including acetyl-, propionyl-, 3-methylcrotonyl-, and geranyl-CoA carboxylases, when grown on the appropriate carbon sources. Acetyl-CoA carboxylase activity in crude extracts was stimulated approximately 40-fold by inclusion of 0.4-0.5 M ammonium sulfate in the
Ray Fall, Mina L. Hector
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Analytical Biochemistry, 1983
A mixture of Ti(IV) and 4-(2-pyridylazo)resorcinol was found to be useful in the spectrophotometric determination of trace amounts of hydrogen peroxide. The absorbance at 508 nm was proportional to the concentration of hydrogen peroxide added. The reagent was successfully applied to the assay of free fatty acid in serum through the combined use of acyl-
Yasushi Yoshida +3 more
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A mixture of Ti(IV) and 4-(2-pyridylazo)resorcinol was found to be useful in the spectrophotometric determination of trace amounts of hydrogen peroxide. The absorbance at 508 nm was proportional to the concentration of hydrogen peroxide added. The reagent was successfully applied to the assay of free fatty acid in serum through the combined use of acyl-
Yasushi Yoshida +3 more
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