Results 21 to 30 of about 2,608,587 (304)

Evaluation of long-chain acyl-coenzyme A synthetase 4 (ACSL4) expression in human breast cancer

Research in Pharmaceutical Sciences, 2020
Background and purpose: Breast cancer (BC) is one of the major causes of female cancer-related death. It has recently been demonstrated that metabolic reprogramming including alteration in lipid metabolism is indicated in various types of cancer.
Negar Dinarvand, H. Khanahmad, S. Hakimian, A. Sheikhi, B. Rashidi, M. Pourfarzam   +5 more
semanticscholar   +1 more source

Time‐resolved multiparameter analytics on a cell‐free production platform for acyl‐CoA precursors

Analytical Science Advances, Volume 3, Issue 11-12, Page 289-296, December 2022., 2022
Abstract Cell‐free biosynthesis is emerging as a very attractive alternative for the production of market‐relevant molecules. The free combination of enzymes, regardless of where they are isolated from, raises the possibility to build more efficient synthetic routes but at the same time leads to higher complexity regarding the analysis of the different
Dominic Maehler, Sandra Hoefgen, Ute Münchberg, Oliver J. Schmitz, Julia Rautschek, Ying Huang, Erik Freier, Vito Valiante   +7 more
wiley   +1 more source

IpdE1-IpdE2 Is a Heterotetrameric Acyl Coenzyme A Dehydrogenase That Is Widely Distributed in Steroid-Degrading Bacteria

Biochemistry, 2020
Steroid-degrading bacteria, including Mycobacterium tuberculosis (Mtb), utilize an architecturally distinct subfamily of acyl coenzyme A dehydrogenases (ACADs) for steroid catabolism.
John E. Gadbery, James W Round, Tianao Yuan, M. Wipperman, K. T. Story, A. Crowe, Israël Casabon, Jie Liu, Xinxin Yang, L. Eltis, N. Sampson   +10 more
semanticscholar   +1 more source

Lipid metabolism in pancreatic cancer: emerging roles and potential targets

Cancer Communications, Volume 42, Issue 12, Page 1234-1256, December 2022., 2022
Abstract Pancreatic cancer is one of the most serious health issues in developed and developing countries, with a 5‐year overall survival rate currently <9%. Patients typically present with advanced disease due to vague symptoms or lack of screening for early cancer detection.
Xinpeng Yin, Ruiyuan Xu, Jianlu Song, Rexiati Ruze, Yuan Chen, Chengcheng Wang, Qiang Xu   +6 more
wiley   +1 more source

In silico identification of potential inhibitors of acyl carrier protein reductase and acetyl CoA carboxylase of Plasmodium falciparum in antimalarial therapy

Frontiers in Drug Discovery, 2023
Malaria caused by Plasmodium falciparum, remains one of the most fatal parasitic diseases that has affected nearly a third of the world’s population. The major impediment to the treatment of malaria is the emergence of resistance of the P.
Elliasu Y. Salifu, James Abugri, James Abugri, Issahaku A. Rashid, Festus Osei, Joseph Atia Ayariga   +5 more
doaj   +1 more source

Functional consequences of brain exposure to saturated fatty acids: From energy metabolism and insulin resistance to neuronal damage

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023
Saturated fatty acids induce insulin resistance in neurons. Neuronal metabolism of palmitic acid alters mitochondrial function. Abstract Introduction Saturated fatty acids (FAs) are the main component of high‐fat diets (HFDs), and high consumption has been associated with the development of insulin resistance, endoplasmic reticulum stress and ...
Karina Sánchez‐Alegría, Clorinda Arias   +1 more
wiley   +1 more source

Applying synthetic biology strategies to bioelectrochemical systems

Electrochemical Science Advances, Volume 2, Issue 6, December 2022., 2022
Abstract Although the past 20 years have seen significant advances in tailoring materials for improving the performance of bioelectrochemical systems, recently, there have been efforts in utilizing the synthetic biology toolkit for engineering organisms for bioelectrochemical systems.
Fangyuan Dong, Olja Simoska, Erin Gaffney, Shelley D. Minteer   +3 more
wiley   +1 more source

A universal pocket in fatty acyl-AMP ligases ensures redirection of fatty acid pool away from coenzyme A-based activation

eLife, 2021
Fatty acyl-AMP ligases (FAALs) channelize fatty acids towards biosynthesis of virulent lipids in mycobacteria and other pharmaceutically or ecologically important polyketides and lipopeptides in other microbes.
Gajanan S Patil, Priyadarshan Kinatukara, Sudipta Mondal, Sakshi Shambhavi, Ketan D Patel, Surabhi Pramanik, Noopur Dubey, Subhash Narasimhan, Murali Krishna Madduri, Biswajit Pal, Rajesh S Gokhale, Rajan Sankaranarayanan   +11 more
doaj   +1 more source

Prebiotic Vitamin B$_3$ Synthesis in Carbonaceous Planetesimals [PDF]

ChemPlusChem 2023, e202300508, 2023
Aqueous chemistry within carbonaceous planetesimals is promising for synthesizing prebiotic organic matter essential to all life. Meteorites derived from these planetesimals delivered these life building blocks to the early Earth, potentially facilitating the origins of life.
arxiv   +1 more source

Molecular rules for selectivity in lipase-catalysed acylation of lysine [PDF]

Process Biochemistry, Elsevier, 2018, 74, pp.50-60, 2019
The selectivity of L-lysine acylation by lauric acid catalysed by Candida antarctica lipase B (CALB) was investigated combining experimental and theoretical methodologies. Experiments showed the near-exclusive acylation of lysine $\epsilon$-amino group; only traces of product resulting from the acylation of lysine $\alpha$-amino group were observed ...
arxiv   +1 more source