Results 301 to 310 of about 89,084 (326)
Some of the next articles are maybe not open access.
Chemical events in chloropropionyl-coenzyme A inactivation of acyl-coenzyme A utilizing enzymes
Biochemistry, 1989Incubation of 3-chloropropionyl-CoA with 3-hydroxy-3-methylglutaryl-CoA synthase results in exchange of the C2 proton with solvent as inactivation of enzyme proceeds. This enzyme is also inhibited by S-acrylyl-N-acetylcysteamine; the limiting rate constant for inactivation by the acrylyl derivative (0.36 min-1) slightly exceeds the value measured for ...
H M, Miziorko, C E, Behnke, F, Ahmad
openaire +2 more sources
Multiple acyl-coenzyme A carboxylases in Pseudomonas citronellolis
Biochemistry, 1976Pseudomonas citronellolis was shown to contain four different acyl-coenzyme A carboxylases, including acetyl-, propionyl-, 3-methylcrotonyl-, and geranyl-CoA carboxylases, when grown on the appropriate carbon sources. Acetyl-CoA carboxylase activity in crude extracts was stimulated approximately 40-fold by inclusion of 0.4-0.5 M ammonium sulfate in the
M L, Hector, R R, Fall
openaire +2 more sources
Analytical Biochemistry, 1991
An assay for 3-oxoacyl-coenzyme A (3-oxoacyl-CoA) thiolases is described. The reaction utilizes acetyldithio-CoA as the nucleophile and variable chain length saturated acyl-CoA's as the electrophiles. The properties of the 3-oxoacyl-CoA dithioester product, notably a pKa of 6.6 +/- 0.1 and an extinction coefficient of 21,600 cm-1 M-1 for the ...
L V, Wrensford +2 more
openaire +2 more sources
An assay for 3-oxoacyl-coenzyme A (3-oxoacyl-CoA) thiolases is described. The reaction utilizes acetyldithio-CoA as the nucleophile and variable chain length saturated acyl-CoA's as the electrophiles. The properties of the 3-oxoacyl-CoA dithioester product, notably a pKa of 6.6 +/- 0.1 and an extinction coefficient of 21,600 cm-1 M-1 for the ...
L V, Wrensford +2 more
openaire +2 more sources
Formation of S-acyl pantetheine from acyl=coenzyme a by plasma membranes
Biochimica et Biophysica Acta (BBA) - Biomembranes, 19681. 1. During incubation of a variety of plasma membrane preparations with S-acyl-CoA esters substantial amounts of a novel lipid were produced. This material was identified as S-acyl pantetheine. 2. 2. Characterization of palmityl pantetheine was achieved by infrared and mass spectrometry, by analysis for its constituent groups and by chemical ...
E G, Trams, W L, Stahl, J, Robinson
openaire +2 more sources
Rat Hepatic Coenzyme A is Redistributed in Response to Mitochondrial Acyl-Coenzyme A Accumulation ,
The Journal of Nutrition, 1992Coenzyme A without an acyl-thioester (CoASH) is required for numerous cellular reactions, and sequestration of CoASH as acyl-CoAs may impair metabolic function. Increased total CoA protects the cell from acyl-CoA accumulation, and enhanced CoA biosynthesis may represent a compensatory response in metabolic disease.
E P, Brass, L J, Ruff
openaire +2 more sources
Acyl-coenzyme-a: Coenzyme-a Acyltransferase--a Novel Mammalian Enzyme.
1973PhD ; Biochemistry ; University of Michigan, Horace H. Rackham School of Graduate Studies ; http://deepblue.lib.umich.edu/bitstream/2027.42/189700/2/7324634 ...
openaire +2 more sources
Photoaffinity labeling of acyl-coenzyme A:glycine N-acyltransferase with p-azidobenzoyl-coenzyme A
Biochemistry, 1977A photolabile reagent, p-azidobenzoyl-CoA, has been synthesized and tested as a photoaffinity label for acyl-CoA:glycine N-acyltransferase (EC 2.3.1.13) from beef liver. p-Azidobenzoyl-CoA is an active-site-directed reagent for this N-acyltransferase, since it is an alternate substrate (Km = 26 micronM, when [glycine] = 100 mM). Ultraviolet irradiation
E P, Lau, B E, Haley, R E, Barden
openaire +2 more sources
Hyperuricemia in medium-chain acyl-coenzyme A dehydrogenase deficiency
The Journal of Pediatrics, 1992Six infants and children with medium-chain acyl-coenzyme A dehydrogenase deficiency were found to have hyperuricemia during an acute episode. Hyperuricemia may be a clue to the diagnosis of medium-chain acyl-coenzyme A dehydrogenase deficiency.
A, Davidson-Mundt +2 more
openaire +2 more sources
Coenzyme A binding sites induce proximal acylation
2022Lysine N?-acylations, such as acetylation, succinylation or glutarylation, are post-translational modifications that regulate protein function. The majority of acylation occurs within the mitochondria in a non-enzymatic fashion. Mitochondrial sirtuins (SIRT3, SIRT4, and SIRT5) are the only known enzymes that remove acyl groups from lysine residues in ...
openaire +1 more source
Hereditary and acquired diseases of acyl-coenzyme A metabolism
Molecular Genetics and Metabolism, 2008Coenzyme A (CoA) sequestration, toxicity or redistribution (CASTOR) is predicted to occur in many hereditary and acquired conditions in which the degradation of organic acyl esters of CoA is impaired. The resulting accumulation of CoA esters and reduction of acetyl-CoA and free CoA (CoASH) will then trigger a cascade of reactions leading to clinical ...
Grant A, Mitchell +5 more
openaire +2 more sources