Results 31 to 40 of about 2,608,587 (304)

Green butyryl-coenzyme A dehydrogenase. An enzyme–acyl-coenzyme A complex [PDF]

Biochemical Journal, 1971
1. Butyryl-CoA dehydrogenase from Peptostreptococcus elsdenii forms very tightly bound complexes with various acyl-CoA compounds. Spectra in some cases merely show resolution of the 450nm band, but those with acetoacetyl-, pent-2-enoyl- and 4-methylpent-2-enoyl-CoA show long-wavelength bands similar to the 710nm band of native enzyme.
Vincent Massey, Paul C. Engel
openaire   +3 more sources

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Asymptotically cylindrical Calabi-Yau 3-folds from weak Fano 3-folds [PDF]

Geom. Topol. 17 (2013) 1955-2059, 2012
We prove the existence of asymptotically cylindrical (ACyl) Calabi-Yau 3-folds starting with (almost) any deformation family of smooth weak Fano 3-folds. This allow us to exhibit hundreds of thousands of new ACyl Calabi-Yau 3-folds; previously only a few hundred ACyl Calabi-Yau 3-folds were known.
arxiv   +1 more source

Preservation of Acyl Coenzyme A Attenuates Pathological and Metabolic Cardiac Remodeling Through Selective Lipid Trafficking.

Circulation, 2019
BACKGROUND Metabolic remodeling in heart failure contributes to dysfunctional lipid trafficking and lipotoxicity. Acyl coenzyme A synthetase-1 (ACSL1) facilitates long-chain fatty acid (LCFA) uptake and activation with coenzyme A (CoA), mediating the ...
J. R. Goldenberg, Andrew N. Carley, R. Ji, Xiaokan Zhang, Matthew Fasano, P. C. Schulze, E. Lewandowski   +6 more
semanticscholar   +1 more source

Molecular Basis of KAT2A Selecting Acyl-CoA Cofactors for Histone Modifications

Research, 2023
Emerging discoveries about undocumented acyltransferase activities of known histone acetyltransferases (HATs) advance our understandings in the regulation of histone modifications. However, the molecular basis of HATs selecting acyl coenzyme A (acyl-CoA)
Sha Li, Nan Li, Jie He, Runxin Zhou, Zhimin Lu, Yizhi Jane Tao, Yusong R. Guo, Yugang Wang   +7 more
doaj   +1 more source

Acyl-Coenzyme A: Cholesterol Acyltransferase Inhibition in Cancer Treatment

Anticancer Research, 2019
Overexpression of acyl-coenzyme A:cholesterol acyltransferase (ACAT) results in increased cholesteryl ester levels and has been involved in a variety of cancer types.
Judyta Zabielska, T. Śledziński, E. Stelmanska   +2 more
semanticscholar   +1 more source

Could Duodenal Molecular Mechanisms be Involved in the Hypocholesterolemic Effect of Silicon Used as Functional Ingredient in Late‐Stage Type 2 Diabetes Mellitus?

Molecular Nutrition &Food Research, Volume 66, Issue 24, December 2022., 2022
Duodenal mucosa in early‐stage type 2 diabetes mellitus (ED), late‐stage type 2 diabetes mellitus injected with streptozotocin‐nicotinamide (STZ/NAD) (LD) and treated‐silicon LD (LD‐Si) groups. Silicon partially reversed LD group alterations: decreased absorptive area and acyl‐Coenzyme A:cholesterol acyltransferase 2 (ACAT2) levels, and increased ...
Marina Hernández‐Martín, Aránzazu Bocanegra, Rocío Redondo‐Castillejo, Adrián Macho‐González, Francisco J. Sánchez‐Muniz, Juana Benedí, Sara Bastida, Rosa A. García‐Fernández, Alba Garcimartín, M. Elvira López‐Oliva   +9 more
wiley   +1 more source

Characterization of the mycobacterial acyl-CoA carboxylase holo complexes reveals their functional expansion into amino acid catabolism.

PLoS Pathogens, 2015
Biotin-mediated carboxylation of short-chain fatty acid coenzyme A esters is a key step in lipid biosynthesis that is carried out by multienzyme complexes to extend fatty acids by one methylene group.
Matthias T Ehebauer, Michael Zimmermann, Arjen J Jakobi, Elke E Noens, Daniel Laubitz, Bogdan Cichocki, Hedia Marrakchi, Marie-Antoinette Lanéelle, Mamadou Daffé, Carsten Sachse, Andrzej Dziembowski, Uwe Sauer, Matthias Wilmanns   +12 more
doaj   +1 more source

Loss of the Mitochondrial Fatty Acid β-Oxidation Protein Medium-Chain Acyl-Coenzyme A Dehydrogenase Disrupts Oxidative Phosphorylation Protein Complex Stability and Function

Scientific Reports, 2018
Medium-chain acyl-Coenzyme A dehydrogenase (MCAD) is involved in the initial step of mitochondrial fatty acid β-oxidation (FAO). Loss of function results in MCAD deficiency, a disorder that usually presents in childhood with hypoketotic hypoglycemia ...
S. C. Lim, M. Tajika, Masaru Shimura, Kirstyn T. Carey, D. Stroud, K. Murayama, A. Ohtake, M. McKenzie   +7 more
semanticscholar   +1 more source

Clinical and Gene Analysis of Fatty Acid Oxidation Disorders Found in Neonatal Tandem Mass Spectrometry Screening

Pharmacogenomics and Personalized Medicine, 2023
Xiaoxia Wang, Haining Fang Department of Pediatrics, Maternal and Child Health Hospital of Hubei Province, Wuhan, 430070, People’s Republic of ChinaCorrespondence: Haining Fang, Department of Pediatrics, Maternal and Child Health Hospital of Hubei ...
Wang X, Fang H
doaj