Results 41 to 50 of about 2,608,587 (304)
A FRET sensor for the real-time detection of long chain acyl-CoAs and synthetic ABHD5 ligands
Cell Reports: Methods, 2023 Summary: Intracellular long-chain acyl-coenzyme As (LC-acyl-CoAs) are thought to be under tight spatial and temporal controls, yet the ability to image LC-acyl-CoAs in live cells is lacking.
Emilio P. Mottillo +6 more
doaj
Journal of Biological Chemistry, 1973 Abstract A particulate preparation isolated from Escherichia coli B catalyzes the acylation of 1-acyl-sn-glycerol 3-phosphate (1-acyl-GP) with both oleoyl-CoA and palmitoyl-CoA. The optimum conditions were determined for the acyl-CoA: 1-acyl-GP acyltransferase.
Harumi Okuyama, Salih J. Wakil
openaire +3 more sources
PLoS ONE, 2016 Dysregulated lipid metabolism contributes to cancer progression. Our previous study indicates that long-chain fatty acyl-Co A synthetase (ACSL) 3 is essential for lipid upregulation induced by endoplasmic reticulum stress.
Wei-Ching Chen +5 more
semanticscholar +1 more source
The Plant Genome, Volume 15, Issue 4, December 2022., 2022 Abstract As an important family of pathogenesis‐related (PR) proteins, the functional diversification and roles of PR10s in biotic stress have been well documented. However, the molecular basis of PR10s in plant defense responses against pathogens remains to be further understood.
Jin Guo +6 more
wiley +1 more source
Associative submanifolds in twisted connected sum $G_2$-manifolds [PDF]
arXiv, 2022 We introduce a new method to construct closed rigid (unobstructed) associative submanifolds in the twisted connected sum $G_2$-manifolds [Kov03, KL11, CHNP15]. More precisely, we prove a gluing theorem of asymptotically cylindrical (ACyl) associative submanifolds in ACyl $G_2$-manifolds under a hypothesis that can be interpreted as a transverse ...
arxiv
Acyl-coenzyme A synthetases in metabolic control
Current Opinion in Lipidology, 2010 The 11 long-chain (ACSL) and very long chain acyl-coenzyme A (acyl-CoA) synthetases [(ACSVL)/fatty acid transport protein] are receiving considerable attention because it has become apparent that their individual functions are not redundant.
Jessica M. Ellis +3 more
openaire +4 more sources
Engineered Production of Short-Chain Acyl-Coenzyme A Esters in Saccharomyces cerevisiae.
ACS Synthetic Biology, 2018 Short-chain acyl-coenzyme A esters serve as intermediate compounds in fatty acid biosynthesis, and the production of polyketides, biopolymers and other value-added chemicals. S.
Nicolas Krink-Koutsoubelis +12 more
semanticscholar +1 more source
Angewandte Chemie, EarlyView.The discovery of LIBX‐A401, a potent and selective ACSL4 inhibitor derived from rosiglitazone is reported. HDX‐MS reveals that LIBX‐A401 stabilizes the ACSL4 C‐terminus and alters the fatty acid (FA) gate domain. Consistently, photoaffinity labeling, molecular dynamics, and mutagenesis identify key binding residues within the FA pocket.
Darius Mazhari Dorooee +19 more
wiley +2 more sources
A Single LC-MS/MS Analysis to Quantify CoA Biosynthetic Intermediates and Short-Chain Acyl CoAs
Metabolites, 2021 Coenzyme A (CoA) is an essential cofactor for dozens of reactions in intermediary metabolism. Dysregulation of CoA synthesis or acyl CoA metabolism can result in metabolic or neurodegenerative disease.
Anthony E. Jones +5 more
doaj +1 more source
Molecular motions in lipid bilayers studied by the neutron backscattering technique [PDF]
Phys. Rev. E 71, 061908 (2005), 2005 We report a high energy-resolution neutron backscattering study to investigate slow motions on nanosecond time scales in highly oriented solid supported phospholipid bilayers of the model system DMPC -d54 (deuterated 1,2-dimyristoyl-sn-glycero-3-phoshatidylcholine), hydrated with heavy water.
arxiv +1 more source