Results 41 to 50 of about 32,362 (145)
Journal of Lipid Research, 2006 Stearoyl-coenzyme A desaturase (SCD) is an endoplasmic reticulum (ER) protein that catalyzes the Δ9-cis desaturation of saturated fatty acids.
Weng Chi Man +3 more
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Metabolic and tissue-specific regulation of acyl-CoA metabolism. [PDF]
PLoS ONE, 2015 Acyl-CoA formation initiates cellular fatty acid metabolism. Acyl-CoAs are generated by the ligation of a fatty acid to Coenzyme A mediated by a large family of acyl-CoA synthetases (ACS).
Jessica M Ellis +2 more
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Proofreading of Noncognate Acyl Adenylates by an Acyl-Coenzyme A Ligase
Chemistry & Biology, 2013 Aminoacyl-tRNA synthetases remove (proofread) incorrect substrates and thereby prevent errors in protein synthesis. We report enzyme-catalyzed pretransfer editing by pimeloyl-coenzyme A (CoA) ligase (BioW), a biotin synthetic enzyme that converts pimelate, a seven-carbon dicarboxylic acid, to its CoA ester.
Manandhar, Miglena, Cronan, John E.
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Journal of Lipid Research, 2019 Diet, hormones, gene transcription, and posttranslational modifications control the hepatic metabolism of FAs; metabolic dysregulation causes chronic diseases, including cardiovascular disease, and warrants exploration into the mechanisms directing FA ...
Rosalind A. Coleman
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Long-chain acyl-CoA synthetase 2 is involved in seed oil production in Brassica napus
BMC Plant Biology, 2020 Background Triacylglycerols (TAGs) are the main composition of plant seed oil. Long-chain acyl-coenzyme A synthetases (LACSs) catalyze the synthesis of long-chain acyl-coenzyme A, which is one of the primary substrates for TAG synthesis.
Li-Na Ding +7 more
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Ligand binding to the ACBD6 protein regulates the acyl-CoA transferase reactions in membranes
Journal of Lipid Research, 2015 The binding determinants of the human acyl-CoA binding domain-containing protein (ACBD) 6 and its function in lipid renewal of membranes were investigated. ACBD6 binds acyl-CoAs of a chain length of 6 to 20 carbons.
Eric Soupene, Frans A. Kuypers
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The Roles of Coenzyme A Binding Pocket Residues in Short and Medium Chain Acyl-CoA Synthetases
Life, 2023 Short- and medium-chain acyl-CoA synthetases catalyze similar two-step reactions in which acyl substrate and ATP bind to form an enzyme-bound acyl-adenylate, then CoA binds for formation of the acyl-CoA product.
Yu Meng +3 more
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Short-chain fatty acids activate acetyltransferase p300
eLife, 2021 Short-chain fatty acids (SCFAs) acetate, propionate, and butyrate are produced in large quantities by the gut microbiome and contribute to a wide array of physiological processes. While the underlying mechanisms are largely unknown, many effects of SCFAs
Sydney P Thomas, John M Denu
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Journal of Lipid Research, 2012 Thioesterase superfamily member 1 (Them1; synonyms acyl-CoA thioesterase 11 and StarD14) is highly expressed in brown adipose tissue and limits energy expenditure in mice. Them1 is a putative fatty acyl-CoA thioesterase that comprises tandem hot dog-fold
Shuxin Han, David E. Cohen
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Parameters of cholesterol metabolism in the human hepatoma cell line, Hep-G2.
Journal of Lipid Research, 1988 The human hepatoma cell line Hep-G2 has been shown to express the major enzymes of intra- and extracellular cholesterol metabolism. These include lecithin:cholesterol acyltransferase, acyl coenzyme A:cholesterol acyltransferase, 3-hydroxy-3 ...
S K Erickson, P E Fielding
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