Results 41 to 50 of about 86,795 (327)

A minimal biochemical route towards de novo formation of synthetic phospholipid membranes. [PDF]

, 2019
All living cells consist of membrane compartments, which are mainly composed of phospholipids. Phospholipid synthesis is catalyzed by membrane-bound enzymes, which themselves require pre-existing membranes for function.
Bhattacharya, Ahanjit, Brea, Roberto J, Devaraj, Neal K, Niederholtmeyer, Henrike   +3 more
core   +2 more sources

Loss of the Mitochondrial Fatty Acid β-Oxidation Protein Medium-Chain Acyl-Coenzyme A Dehydrogenase Disrupts Oxidative Phosphorylation Protein Complex Stability and Function

Scientific Reports, 2018
Medium-chain acyl-Coenzyme A dehydrogenase (MCAD) is involved in the initial step of mitochondrial fatty acid β-oxidation (FAO). Loss of function results in MCAD deficiency, a disorder that usually presents in childhood with hypoketotic hypoglycemia ...
S. C. Lim, M. Tajika, Masaru Shimura, Kirstyn T. Carey, D. Stroud, K. Murayama, A. Ohtake, M. McKenzie   +7 more
semanticscholar   +1 more source

Characterization of the mycobacterial acyl-CoA carboxylase holo complexes reveals their functional expansion into amino acid catabolism.

PLoS Pathogens, 2015
Biotin-mediated carboxylation of short-chain fatty acid coenzyme A esters is a key step in lipid biosynthesis that is carried out by multienzyme complexes to extend fatty acids by one methylene group.
Matthias T Ehebauer, Michael Zimmermann, Arjen J Jakobi, Elke E Noens, Daniel Laubitz, Bogdan Cichocki, Hedia Marrakchi, Marie-Antoinette Lanéelle, Mamadou Daffé, Carsten Sachse, Andrzej Dziembowski, Uwe Sauer, Matthias Wilmanns   +12 more
doaj   +1 more source

Molecular Basis of KAT2A Selecting Acyl-CoA Cofactors for Histone Modifications

Research, 2023
Emerging discoveries about undocumented acyltransferase activities of known histone acetyltransferases (HATs) advance our understandings in the regulation of histone modifications. However, the molecular basis of HATs selecting acyl coenzyme A (acyl-CoA)
Sha Li, Nan Li, Jie He, Runxin Zhou, Zhimin Lu, Yizhi Jane Tao, Yusong R. Guo, Yugang Wang   +7 more
doaj   +1 more source

Clinical and Gene Analysis of Fatty Acid Oxidation Disorders Found in Neonatal Tandem Mass Spectrometry Screening

Pharmacogenomics and Personalized Medicine, 2023
Xiaoxia Wang, Haining Fang Department of Pediatrics, Maternal and Child Health Hospital of Hubei Province, Wuhan, 430070, People’s Republic of ChinaCorrespondence: Haining Fang, Department of Pediatrics, Maternal and Child Health Hospital of Hubei ...
Wang X, Fang H
doaj  

Rat long-chain acyl-CoA synthetase mRNA, protein, and activity vary in tissue distribution and in response to diet

Journal of Lipid Research, 2006
Distinct isoforms of long-chain acyl-CoA synthetases (ACSLs) may partition fatty acids toward specific metabolic cellular pathways. For each of the five members of the rat ACSL family, we analyzed tissue mRNA distributions, and we correlated the mRNA ...
Douglas G. Mashek, Lei O. Li, Rosalind A. Coleman   +2 more
doaj   +1 more source

Biosynthesis of thiocarboxylic acid-containing natural products. [PDF]

, 2018
Thiocarboxylic acid-containing natural products are rare and their biosynthesis and biological significance remain unknown. Thioplatensimycin (thioPTM) and thioplatencin (thioPTN), thiocarboxylic acid congeners of the antibacterial natural products ...
Deng, Youchao, Dong, Liao-Bin, Duan, Yanwen, He, Cyndi Qixin, Houk, KN, Huang, Yong, Kang, Dingding, Rudolf, Jeffrey D, Shen, Ben, Wang, Nan   +9 more
core   +1 more source

Activation of hypolipidaemic drugs to acyl-coenzyme A thioesters [PDF]

Biochemical Journal, 1986
Compounds possessing the characteristics of CoA thioesters of the hypolipidaemic peroxisome proliferators clofibric acid, nafenopin and ciprofibrate were formed on incubation of the drugs with rat liver microsomal fractions, ATP and CoA. The reactivity of the drugs correlated with their pharmacological potency. It is proposed that the active species of
BRONFMAN, M, AMIGO, L, MORALES, MN
openaire   +3 more sources

Corresponding increase in long-chain acyl-CoA and acylcarnitine after exercise in muscle from VLCAD mice

Journal of Lipid Research, 2009
Long-chain acylcarnitines accumulate in long-chain fatty acid oxidation defects, especially during periods of increased energy demand from fat. To test whether this increase in long-chain acylcarnitines in very long-chain acyl-CoA dehydrogenase (VLCAD−/−)
Frank ter Veld, Sonja Primassin, Lars Hoffmann, Ertan Mayatepek, Ute Spiekerkoetter   +4 more
doaj   +1 more source

Positional Specificities of Acyl Coenzyme A:Glycerophosphate and Acyl Coenzyme A:Monoacylglycerophosphate Acyltransferases in Escherichia coli

Journal of Biological Chemistry, 1973
Abstract A particulate preparation isolated from Escherichia coli B catalyzes the acylation of 1-acyl-sn-glycerol 3-phosphate (1-acyl-GP) with both oleoyl-CoA and palmitoyl-CoA. The optimum conditions were determined for the acyl-CoA: 1-acyl-GP acyltransferase.
Harumi Okuyama, Salih J. Wakil
openaire   +3 more sources