Results 51 to 60 of about 2,608,587 (304)
Purification and Characterization of a Novel Pumpkin Short-Chain Acyl-Coenzyme A Oxidase with Structural Similarity to Acyl-Coenzyme A Dehydrogenases [PDF]
Plant Physiology, 2000 Abstract A novel pumpkin (Cucurbita pepo) short-chain acyl-coenzyme A (CoA) oxidase (ACOX) was purified to homogeneity by hydrophobic-interaction, hydroxyapatite, affinity, and anion-exchange chromatography. The purified enzyme is a tetrameric protein, consisting of apparently identical 47-kD subunits.
DE BELLIS L. +5 more
openaire +3 more sources
Angewandte Chemie, EarlyView.Lsd18 is a flavin‐dependent monooxygenase from Streptomyces lasalocidi that performs two enantioselective epoxidations during lasalocid A biosynthesis. X‐ray crystal structures of Lsd18 bound to a substrate and product analogue illuminate how this enzyme performs multiple epoxidations on the same substrate molecule and how it controls stereoselectivity.
Qian Wang +12 more
wiley +2 more sources
Plants, 2020 The spectral quality and intensity of light, photoperiodism, and other environmental factors have profound impacts on the metabolic composition of light-dependent higher plants.
Muthusamy Muthusamy +10 more
doaj +1 more source
Chain ordering of phospholipids in membranes containing cholesterol: What matters? [PDF]
arXiv, 2021 Cholesterol (CHOL) drives lipid segregation and is thus a key player for the formation of lipid rafts and followingly for the ability of a cell to, e.g., enable selective agglomeration of proteins. The lipid segregation is driven by cholesterol's affinity for saturated lipids, which stands directly in relation to the ability of cholesterol to order the
arxiv
Activation of hypolipidaemic drugs to acyl-coenzyme A thioesters [PDF]
Biochemical Journal, 1986 Compounds possessing the characteristics of CoA thioesters of the hypolipidaemic peroxisome proliferators clofibric acid, nafenopin and ciprofibrate were formed on incubation of the drugs with rat liver microsomal fractions, ATP and CoA. The reactivity of the drugs correlated with their pharmacological potency. It is proposed that the active species of
M. Morales +2 more
openaire +3 more sources
Antimicrobial Agents and Chemotherapy, 2016 Pyrazinamide (PZA) is a first-line tuberculosis (TB) drug that has been in clinical use for 60 years yet still has an unresolved mechanism of action.
Brandon C. Rosen +4 more
semanticscholar +1 more source
A Missing Key to Understand the Electrical Resonance and the Mechanical Property of Neurons: a Channel-Membrane Interaction Mechanism [PDF]
arXiv, 2023 The recent study of the interaction between the fatty acyl tails of lipids and the K+ channel establishes the connection between flexoelectricity and the ion channel's dynamics, named Channel-Membrane Interaction (CMI), that may solve the electrical resonance in neurons.
arxiv
Short-chain acyl-coenzyme A dehydrogenase deficiency [PDF]
Molecular Genetics and Metabolism, 2008 Short-chain acyl-CoA dehydrogenase deficiency (SCADD) is a disorder of mitochondrial fatty acid oxidation that leads to the accumulation of butyrylcarnitine and ethylmalonic acid in blood and urine. Originally described with a relatively severe phenotype, most patients are now diagnosed through newborn screening by tandem mass spectrometry and remain ...
Jerry Vockley +2 more
openaire +3 more sources
eLife, 2013 Large Ca transients cause massive endocytosis (MEND) in BHK fibroblasts by nonclassical mechanisms. We present evidence that MEND depends on mitochondrial permeability transition pore (PTP) openings, followed by coenzyme A (CoA) release, acyl CoA ...
Donald W Hilgemann +4 more
doaj +1 more source
Characterization of a Bifunctional Archaeal Acyl Coenzyme A Carboxylase [PDF]
Journal of Bacteriology, 2003 ABSTRACT Acyl coenzyme A carboxylase (acyl-CoA carboxylase) was purified from Acidianus brierleyi . The purified enzyme showed a unique subunit structure (three subunits with apparent molecular masses of 62, 59, and 20 kDa) and a molecular mass of approximately 540 kDa, indicating an α 4
Yasuo Igarashi +3 more
openaire +3 more sources