Results 51 to 60 of about 31,267 (192)

Functional characterization of thioesterase superfamily member 1/Acyl-CoA thioesterase 11: implications for metabolic regulation[S]

Journal of Lipid Research, 2012
Thioesterase superfamily member 1 (Them1; synonyms acyl-CoA thioesterase 11 and StarD14) is highly expressed in brown adipose tissue and limits energy expenditure in mice. Them1 is a putative fatty acyl-CoA thioesterase that comprises tandem hot dog-fold
Shuxin Han, David E. Cohen
doaj   +1 more source

Parameters of cholesterol metabolism in the human hepatoma cell line, Hep-G2.

Journal of Lipid Research, 1988
The human hepatoma cell line Hep-G2 has been shown to express the major enzymes of intra- and extracellular cholesterol metabolism. These include lecithin:cholesterol acyltransferase, acyl coenzyme A:cholesterol acyltransferase, 3-hydroxy-3 ...
S K Erickson, P E Fielding
doaj   +1 more source

Acyl-Coenzyme A: Cholesterol Acyltransferase Inhibition in Cancer Treatment [PDF]

Anticancer Research, 2019
Overexpression of acyl-coenzyme A:cholesterol acyltransferase (ACAT) results in increased cholesteryl ester levels and has been involved in a variety of cancer types. As a consequence, cholesterol metabolism has raised interest as a potential target for cancer treatment.
Ewa Stelmanska, Judyta Zabielska, Tomasz Sledzinski   +2 more
openaire   +2 more sources

Immunolocalization of Acyl-Coenzyme A:CholesterolO-Acyltransferase in Macrophages [PDF]

Journal of Biological Chemistry, 1998
Macrophages in atherosclerotic lesions accumulate large amounts of cholesteryl-fatty acyl esters ("foam cell" formation) through the intracellular esterification of cholesterol by acyl-coenzyme A:cholesterol O-acyltransferase (ACAT). In this study, we sought to determine the subcellular localization of ACAT in macrophages.
Ira Tabas, Robert V. Farese, Nanda Beatini, Hongxing Wang, Ta-Yuan Chang, Frederick R. Maxfield, Vardiella L. Meiner, Xavier Buton, Nadia Khelef   +8 more
openaire   +3 more sources

Identification and characterization of an acyl-CoA:triterpene acyltransferase activity in rabbit and human tissues.

Journal of Lipid Research, 1991
Rabbit and human tissues contain substantial amounts of an unusual lipid, a fatty acid ester of a pentacyclic triterpene, that is a potent in vitro inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT). A possible origin of the triterpene ester is via
I Tabas, N Beatini, LL Chen, WC Su, MS Puar, S Dugar, JW Clader   +6 more
doaj   +1 more source

ETFDH mutation involves excessive apoptosis and neurite outgrowth defect via Bcl2 pathway

Scientific Reports
The most common mutation in southern Chinese individuals with late-onset multiple acyl-coenzyme A dehydrogenase deficiency (MADD; a fatty acid metabolism disorder) is c.250G > A (p.Ala84Thr) in the electron transfer flavoprotein dehydrogenase gene (ETFDH)
Chuang-Yu Lin, Wen-Chen Liang, Yi-Chen Yu, Shin-Cheng Chang, Ming-Chi Lai, Yuh-Jyh Jong   +5 more
doaj   +1 more source

Functions of Coenzyme A and Acyl-CoA in Post-Translational Modification and Human Disease

Frontiers in Bioscience-Landmark
Coenzyme A (CoA) is synthesized from pantothenate, L-cysteine and adenosine triphosphate (ATP), and plays a vital role in diverse physiological processes. Protein acylation is a common post-translational modification (PTM) that modifies protein structure,
Jumin Xie, Zhang Yu, Ying Zhu, Mei Zheng, Yanfang Zhu   +4 more
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Catalytic properties of MGAT3, a putative triacylgycerol synthases⃞

Journal of Lipid Research, 2007
Acyl-coenzyme A:monoacylglycerol acyltransferase 3 (MGAT3) is a member of the MGAT family of enzymes that catalyze the synthesis of diacylglycerol (DAG) from monoacylglycerol (MAG), a committed step in dietary fat absorption.
Jingsong Cao, Long Cheng, Yuguang Shi
doaj   +1 more source

RICE ACYL-COA-BINDING PROTEIN6 Affects Acyl-CoA Homeostasis and Growth in Rice

Rice, 2020
Backgrounds Acyl-coenzyme A (CoA) esters are important intermediates in lipid metabolism with regulatory properties. Acyl-CoA-binding proteins bind and transport acyl-CoAs to fulfill these functions.
Wei Meng, Lijian Xu, Zhi-Yan Du, Fang Wang, Rui Zhang, Xingshun Song, Sin Man Lam, Guanghou Shui, Yuhua Li, Mee-Len Chye   +9 more
doaj   +1 more source

Immunodepletion experiments suggest that acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) protein plays a major catalytic role in adult human liver, adrenal gland, macrophages, and kidney, but not in intestines

Journal of Lipid Research, 1998
The first acyl-coenzyme A:cholesterol acyltransferase (ACAT) cDNA cloned and expressed in 1993 is designated as ACAT-1. In various human tissue homogenates, ACAT-1 protein is effectively solubilized with retention of enzymatic activity by the detergent ...
Oneil Lee, Catherine C.Y. Chang, William Lee, Ta-Yuan Chang   +3 more
doaj   +1 more source