Results 61 to 70 of about 2,608,587 (304)

Chemoenzymatic Synthesis of Acyl Coenzyme A Substrates Enables in Situ Labeling of Small Molecules and Proteins.

Organic Letters, 2015
A chemoenzymatic approach to generate fully functional acyl coenzyme A molecules that are then used as substrates to drive in situ acyl transfer reactions is described.
V. Agarwal, S. Diethelm, L. Ray, Neha Garg, T. Awakawa, P. Dorrestein, B. Moore   +6 more
semanticscholar   +1 more source

Metabolic and tissue-specific regulation of acyl-CoA metabolism. [PDF]

PLoS ONE, 2015
Acyl-CoA formation initiates cellular fatty acid metabolism. Acyl-CoAs are generated by the ligation of a fatty acid to Coenzyme A mediated by a large family of acyl-CoA synthetases (ACS).
Jessica M Ellis, Caitlyn E Bowman, Michael J Wolfgang   +2 more
doaj   +1 more source

Characterization of Novel Acyl Coenzyme A Dehydrogenases Involved in Bacterial Steroid Degradation

Journal of Bacteriology, 2015
The acyl coenzyme A (acyl-CoA) dehydrogenases (ACADs) FadE34 and CasC, encoded by the cholesterol and cholate gene clusters of Mycobacterium tuberculosis and Rhodococcus jostii RHA1, respectively, were successfully purified.
Amanda Ruprecht, Jay C. Maddox, A. J. Stirling, Nicole Visaggio, S. Seah   +4 more
semanticscholar   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Pathway‐based integration of multi‐omics data reveals lipidomics alterations validated in an Alzheimer's disease mouse model and risk loci carriers

Journal of Neurochemistry, Volume 164, Issue 1, Page 57-76, January 2023., 2023
A genome‐scale model network was built for Alzheimer's disease (AD) using data from publicly available genome‐wide association studies in humans, and transcriptomics and proteomics data from brain tissue from mouse models of AD. The derived network was characterized by gene ontology, transcription factor analysis, and pathway and cell‐type enrichment ...
Monica Emili Garcia‐Segura, Brenan R. Durainayagam, Sonia Liggi, Gonçalo Graça, Beatriz Jimenez, Abbas Dehghan, Ioanna Tzoulaki, Ibrahim Karaman, Paul Elliott, Julian L. Griffin   +9 more
wiley   +1 more source

Functional Characterization of GhACX3 Gene Reveals Its Significant Role in Enhancing Drought and Salt Stress Tolerance in Cotton

Frontiers in Plant Science, 2021
The acyl-coenzyme A oxidase 3 (ACX3) gene involved in the β-oxidation pathway plays a critical role in plant growth and development as well as stress response.
Margaret L. Shiraku, Richard Odongo Magwanga, Richard Odongo Magwanga, Xiaoyan Cai, Joy Nyangasi Kirungu, Yanchao Xu, Teame Gereziher Mehari, Yuqing Hou, Yuhong Wang, Stephen Gaya Agong, Renhai Peng, Kunbo Wang, Zhongli Zhou, Fang Liu   +13 more
doaj   +1 more source

Two Activities of Long-Chain Acyl-Coenzyme A Synthetase Are Involved in Lipid Trafficking between the Endoplasmic Reticulum and the Plastid in Arabidopsis1

Plant Physiology, 2014
Lipid reassembly is a key step in the transfer of cytosolic lipid precursors to the plastid. In plants, fatty acids are synthesized within the plastid and need to be distributed to the different sites of lipid biosynthesis within the cell.
Dirk Jessen, Charlotte Roth, M. Wiermer, Martin Fulda   +3 more
semanticscholar   +1 more source

SIRT4 Promotes Pancreatic Cancer Stemness by Enhancing Histone Lactylation and Epigenetic Reprogramming Stimulated by Calcium Signaling

Advanced Science, EarlyView.
As a downstream target of α2δ1‐mediated calcium signaling, SIRT4 serves as an oncogene to promote the stemness of pancreatic cancer via deacetylating ENO1 directly at K358, leading to attenuated ENO1's RNA‐binding capacity, enhanced glycolytic substrate 2‐PG binding and robust glycolytic activity to increase the level of lactate that induce histone ...
Mengzhu Lv, Xiaodan Yang, Congcong Xu, Qingru Song, Hailian Zhao, Tianjiao Sun, Jingtao Liu, Yuan Zhang, Guogui Sun, Yuanchao Xue, Zhiqian Zhang   +10 more
wiley   +1 more source

Roles of acyl‐coenzyme A synthetase family members in airway epithelia cells

Clinical and Translational Discovery, 2023
Background The fundamental initial step in the metabolic process of fatty acids (FA) is facilitated by Acyl‐coenzyme A synthetase (ACS). ACS enables FAs to engage in both anabolic and catabolic pathways by creating thioester bonds with CoA, thus ...
Linlin Zhang, Xuanqi Liu, Liyang Li, Bijun Zhu, Zhihong Chen, Jiayun Hou, Yuanlin Song, Xiangdong Wang   +7 more
doaj   +1 more source

Transcriptional Regulation by the Short-Chain Fatty Acyl Coenzyme A Regulator (ScfR) PccR Controls Propionyl Coenzyme A Assimilation by Rhodobacter sphaeroides

Journal of Bacteriology, 2015
Propionyl coenzyme A (propionyl-CoA) assimilation by Rhodobacter sphaeroides proceeds via the methylmalonyl-CoA pathway. The activity of the key enzyme of the pathway, propionyl-CoA carboxylase (PCC), was upregulated 20-fold during growth with propionate
Michael S Carter, B. Alber
semanticscholar   +1 more source