Results 81 to 90 of about 31,319 (243)

Rat Intestinal Acyl Coenzyme A: Cholesterol Acyl Transferase Properties and Localization

Experimental Biology and Medicine, 1984
Microsomal acyl coenzyme A:cholesterol acyltransferase activity of rat intestinal mucosa was measured as the incorporation of [1-14C]oleic acid into cholesterol esters. Exogenous cholesterol and sterol carrier protein singly and together extended the time over which the reaction rate was linear. Cholesterol esterification was suppressed by 2-monooleoyl
George V. Vahouny, L L Gallo, Susan Myers   +2 more
openaire   +3 more sources

Cuticular waxes in alpine grassland plants: Chemical diversity, biosynthesis, and ecological adaptation with biotechnological insights

Grassland Research, EarlyView.
Alpine plants use specialized cuticular waxes to survive extreme cold, UV radiation, and drought. This study explores how these waxes adapt to environmental stress, revealing their chemical diversity, biosynthesis, and ecological roles. Understanding these adaptations can inspire innovations in climate‐resilient crops and UV‐protective bioproducts ...
Jiawei Xu, Jinjing Wang, Jiahao Huang, Yushan Tao, Yanjun Guo   +4 more
wiley   +1 more source

A Chemo-Enzymatic Road Map to the Synthesis of CoA Esters

Molecules, 2016
Coenzyme A (CoA) is a ubiquitous cofactor present in every known organism. The thioesters of CoA are core intermediates in many metabolic processes, such as the citric acid cycle, fatty acid biosynthesis and secondary metabolism, including polyketide ...
Dominik M. Peter, Bastian Vögeli, Niña Socorro Cortina, Tobias J. Erb   +3 more
doaj   +1 more source

Rewriting the MASLD‐associated hepatocellular carcinoma script: Targeting epigenetics and metabolism

International Journal of Cancer, EarlyView.
Abstract Abnormal epigenetic patterns are crucial for the progression of metabolic‐associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC) development. Recent research focused on the interplay between epigenetics and altered metabolic pathways in HCC from MASLD, suggesting that the reversibility of epigenetic changes offers ...
Chiara Aiello, Eric Felli, Teresa Musarra, Lorenzo Nevi, Annamaria Altomare, Jordi Gracia‐Sancho, Andrea Baiocchini, Simone Carotti   +7 more
wiley   +1 more source

Autoacylation of myelin proteolipid protein with acyl coenzyme A.

Journal of Biological Chemistry, 1987
Rat brain myelin proteolipid protein (PLP) is known to contain long chain, covalently bound fatty acids. In the course of characterizing the mechanism of acylation, we found that the isolated PLP, in the absence of any membrane fraction, was esterified after incubation with [3H]palmitoyl coenzyme A (CoA).
Marjorie B. Lees, Oscar A. Bizzozero, James F. McGarry   +2 more
openaire   +3 more sources

Ferroptosis in Pneumoconiosis: From Molecular and Cellular Mechanisms to Therapeutic Strategies

Med Research, EarlyView.
Targeting lung various cells to alleviate pneumoconiosis by suppressing ferroptosis. AAV9‐HGF, adeno‐associated virus‐hepatocyte growth factor; DFP, deferiprone; DHQ, dihydroquercetin; Fer‐1, ferrostatin‐1; IL‐1β, interleukin‐1β; NMN, nicotinamide mononucleotide; sh‐SLC39A14, shRNA targeting solute carrier family 39 member 14; si‐OC‐STAMP, siRNA ...
Mengli Yan, Jing Zhang, Gaili Ji, Xiaobin Fang, Chunheng Mo   +4 more
wiley   +1 more source

Long-chain acyl-CoA synthetase isoforms differ in preferences for eicosanoid species and long-chain fatty acids[S]

Journal of Lipid Research, 2017
Because the signaling eicosanoids, epoxyeicosatrienoic acids (EETs) and HETEs, are esterified to membrane phospholipids, we asked which long-chain acyl-CoA synthetase (ACSL) isoforms would activate these molecules and whether the apparent FA substrate ...
Eric L. Klett, Shufen Chen, Alekhya Yechoor, Fred B. Lih, Rosalind A. Coleman   +4 more
doaj   +1 more source

The effects and mechanisms of stem cells and exosomes on neurological function protection and recovery after ischemic stroke

Neuroprotection, EarlyView.
Effect and mechanism of stem cells and exosomes therapy in ischemic stroke. The effect and mechanism include protection of neuron and glial cells, repairment of nerve vascular unit, reduction of inflammation response, restoration of white matter integrity, reconstruction of neural circuit, replacement of neurons and glial cells, and anti‐ferroptosis ...
Weihong Du, Yuxian He, Liangchen Li, Xinchun Jin, Panpan Geng   +4 more
wiley   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Proteome‐Wide 4‐Hydroxy‐2‐Nonenal Signature of Oxidative Stress in the Marine Invasive Tunicate Botryllus schlosseri

PROTEOMICS, EarlyView.
ABSTRACT The ascidian Boytryllus schlosseri is a marine chordate that thrives under conditions of anthropogenic climate change. The B. schlosseri expressed proteome contains unusually high levels of proteins adducted with 4‐hydroxy‐2‐nonenal (HNE). HNE represents a prominent posttranslational modification resulting from oxidative stress.
Dietmar Kültz, Alison M. Gardell, Anthony DeTomaso, Greg Stoney, Baruch Rinkevich, Andy Qarri, Jens Hamar   +6 more
wiley   +1 more source