Results 321 to 330 of about 63,314 (347)
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1983
Publisher Summary This chapter focuses on carnitine acyltransferases. The carnitine enzyme with a large acyl transfer capacity for acetyl residues is called “carnitine acetyltransferase” (CAT), whereas the enzyme, which has a high transfer capacity for palmityl residues, is named “carnitine palmityltransferase” (CPT).
Loran L. Bieber, Shawn Farrell
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Publisher Summary This chapter focuses on carnitine acyltransferases. The carnitine enzyme with a large acyl transfer capacity for acetyl residues is called “carnitine acetyltransferase” (CAT), whereas the enzyme, which has a high transfer capacity for palmityl residues, is named “carnitine palmityltransferase” (CPT).
Loran L. Bieber, Shawn Farrell
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DHHC2 is a proteinS-acyltransferase for Lck
Molecular Membrane Biology, 2011Lck is a non-receptor tyrosine kinase of the Src family that is essential for T cell activation. Dual N-terminal acylation of Lck with myristate (N-acylation) and palmitate (S-acylation) is essential for its membrane association and function. Reversible S-acylation of Lck is observed in vivo and may function as a control mechanism. Here we identify the
Zeidman, Ruth +5 more
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Acyltransferases and Triacylglycerols
2018Glycerolipids, by far the largest group of plant lipids, are structurally based on glycerol. This group includes glycodiacylglycerols, phospholipids, and acylglycerols such as triacylglycerol. The properties of the triacylglycerols depend on the fatty acids esterified with each of the three hydroxyl groups of glycerol.
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A protein cofactor of lecithin:Cholesterol acyltransferase
Biochemical and Biophysical Research Communications, 1972Abstract The effect of proteins isolated from human high density lipoprotein on cholesterol esterification by purified lecithin:cholesterol acyltransferase in the presence of dispersed lipids was studied. One of the major proteins present gave a maximal rate of esterification similar to that found with the native lipoprotein.
V.G. Shore +5 more
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Inhibitors of Acyl CoA:Cholesterol Acyltransferase
Journal of Medicinal Chemistry, 1996Conformational restriction of previously disclosed acyclic (diphenylethyl)diphenylacetamides led to the discovery of several potent inhibitors of acyl CoA:cholesterol acyltransferase (ACAT). cis-[2-(4-Hydroxyphenyl)-1-indanyl]diphenylacetamide (4a) was the most potent ACAT inhibitor identified (IC50 = 0.04 microM in an in vitro rat hepatic microsomal ...
Rosy Sher +9 more
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Diabetes, obesity and metabolism, 2014
Inhibition of diacylglycerol acyltransferase 1 (DGAT1) is a potential treatment modality for patients with type 2 diabetes mellitus and obesity, based on preclinical data suggesting it is associated with insulin sensitization and weight loss.
H. Denison +8 more
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Inhibition of diacylglycerol acyltransferase 1 (DGAT1) is a potential treatment modality for patients with type 2 diabetes mellitus and obesity, based on preclinical data suggesting it is associated with insulin sensitization and weight loss.
H. Denison +8 more
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Purification and Characterization of Lecithin:Cholesterol Acyltransferase
Scandinavian Journal of Clinical and Laboratory Investigation, 1978The purification of lecithin:cholesterol acyltransferase (LCAT] from human plasma is reported. Hydroxylapatite fractions were approximately 16,000 fold purified over the starting plasma and were free of high-density lipoprotein (HDL) and albumin.
K G Varma, E Gustow, L A Soloff
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[8] Lysophosphatidylcholine acyltransferase
1992Publisher Summary This chapter discusses lysophosphatidylcholine acyltransferase. Lyso-PC:acyl-CoA acyltransferase activity is detected in various mammalian tissues, bacteria, protozoa, and plants. The transfer of acyl groups from acyl-CoA to 1-acylglycerophosphocholine (1-acyl-GPC) is catalyzed by 1-acyl-GPC: acyl-CoA acyltransferase, whereas ...
Patrick C. Paul +2 more
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Mammalian acyl-CoA:cholesterol acyltransferases
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2000Cholesterol, the chief sterol found in vertebrates, exists both as a free sterol and as a component of cholesterol esters, which are synthesized by acyl-CoA:cholesterol acyltransferase (ACAT) enzymes. Considerable knowledge concerning cholesterol ester metabolism has accumulated during the past century. However, rapid advances have occurred in the past
Michel Accad +2 more
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Lecithin:retinol acyltransferase in ARPE-19
Experimental Eye Research, 2005The purpose of this study is to investigate if a readily available cell line (APRE-19) may be used to study in vitro function of visual cycle enzymes such as lecithin:retinol acyltransferase (LRAT). Cells incubated with exogenous retinol accumulated intracellular all-trans retinol and all-trans retinyl ester.
Steven T. Schuschereba +3 more
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