Enhanced synthesis of 1, 3-medium chain-2-long chain triacylglycerols by engineered Saccharomyces cerevisiae. [PDF]
Peng Z +5 more
europepmc +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Reversible S-palmitoylation of C4 protein encoded by TYLCCxV orchestrates geminiviral pathogenesis. [PDF]
Xie Y +9 more
europepmc +1 more source
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang +17 more
wiley +1 more source
Biocatalytic Regioselective C-Formylation of Resorcinol Derivatives. [PDF]
Gal L +6 more
europepmc +1 more source
Stage‐Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis
Stage‐specific succinylation of histone H3 at lysine 14 and 23 differentially controls insect metamorphosis and oogenesis through distinct GPCR‐PKC signaling cascades, revealing an evolutionarily conserved epigenetic mechanism that coordinates key life‐history traits.
Yu‐Pu Jing +9 more
wiley +1 more source
Identification of key genes governing diester alkaloid biosynthesis in different tissues of Aconitum kusnezoffii. [PDF]
Wu R +6 more
europepmc +1 more source
ABSTRACT Radiation therapy (RT) is a mainstay of treatment for a myriad of cancers, often utilized for tumors that are unable to be resected, as well as an adjunct to surgery and chemotherapy. Unfortunately, many cancers are resistant to RT‐induced damage and subsequent cell death.
Joseph Carmicheal +4 more
wiley +1 more source
The Postprandial Chronobiome in Interorgan Glucose Homeostasis
The postprandial chronobiome framework proposes that meal‐timed oscillations in microbial communities and metabolites may interact with host tissue clocks to shape glucose handling. The liver is the best‐supported temporal interpreter, while phase‐aware human studies are needed to establish causal interorgan effects.
Josko Bozic, Roko Santic, Marko Kumric
wiley +1 more source
Changes in palmitate- and stearate-containing glycerophospholipids in skeletal muscle during clenbuterol-induced fast-twitch fiber transition and hypertrophy. [PDF]
Suzuki Y +5 more
europepmc +1 more source

