Results 111 to 120 of about 22,161 (218)

ADAM10 [PDF]

Science-Business eXchange, 2011
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Non-canonical function of ADAM10 in presynaptic plasticity

Cellular and Molecular Life Sciences
AbstractA Disintegrin And Metalloproteinase 10 (ADAM10) plays a pivotal role in shaping neuronal networks by orchestrating the activity of numerous membrane proteins through the shedding of their extracellular domains. Despite its significance in the brain, the specific cellular localization of ADAM10 remains not well understood due to a lack of ...
Julia Bär, Tomas Fanutza, Christopher C. Reimann, Lisa Seipold, Maja Grohe, Janike Rabea Bolter, Flemming Delfs, Michael Bucher, Christine E. Gee, Michaela Schweizer, Paul Saftig, Marina Mikhaylova   +11 more
openaire   +3 more sources

Regulation of ADAM10 activity through microdomain-dependent intracellular calcium changes

Cell Communication and Signaling
A disintegrin and metalloproteinases (ADAMs) are transmembrane proteases that cleave other proteins close to the surface in a process called shedding.
Federico Guillermo Gharzia, Ahmad Aljohmani, Andreas Beck, Stephan E. Philipp, Daniela Yildiz   +4 more
doaj   +1 more source

Metastasis-associated C4. 4A, A GPI-anchored protein cleaved by ADAM10 and ADAM17 [PDF]

, 2009
Comunicaciones a ...
Arribas, J., Baessmann, C., Canals, Francesc, Colomé, Núria, Esselens, C.W., Jabs, W., Malapeira, J., Suckau, D.   +7 more
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Lack of association between ADAM10 expression and immune thrombocytopenia in children: a case‒control study

Egyptian Pediatric Association Gazette
Background Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by dysregulated T-cell responses, leading to increased platelet destruction and impaired platelet production.
Nouran Momen, Shahira K. A. Botros, Reham A. Khattab, Rasha A. Afifi, Lamyaa H. Soliman   +4 more
doaj   +1 more source

Metastasis-associated C.,4A, A GPI-Anchored protein cleaved by Adam10 and Adam 17 [PDF]

, 2009
Comunicaciones a ...
Arribas, J., Baessmann, C., Canals, Francesc, Colomé, Núria, Esselens, C.W., Jabs, W., Malapeira, J., Suckau, D.   +7 more
core  

The effect of overexpressing SNX8 on the phenotype of Alzheimer’s mice [PDF]

, 2015
阿尔茨海默病（Alzheimerdisease，AD）是最为常见的神经退行性疾病。神经元胞外Aβ（Amyloidβ，Aβ）聚集形成的淀粉样斑是AD的一个重要的病理特征，而Aβ是由淀粉样前体蛋白APP（AmyloidPrecursorProtein，APP）经β-分泌酶（β-secretase）和γ-分泌酶（γ-secretase）依次切割后生成的（即淀粉样蛋白途径），而APP的另一条剪切途径是α-分泌酶（α-secretase）和γ-分泌酶依次对其进行剪切，释放有神经保护作用的sAPPα ...
纪成香
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ADAM10 in myelination of the central nervous system : study of ADAM10 localization and development of an inducible oligodendroglial ADAM10 knock out (KOOLA10) mouse strain

, 2022
In the central nervous system (CNS), oligodendrocytes (OL) envelop the axons with their membrane extensions, forming the myelin sheath. The OL death and the loss of myelin (demyelination) occur in demyelinating diseases such as multiple sclerosis, for which there is no specific cure nowadays.
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AKT activation triggers Rab14-mediated ADAM10 translocation to the cell surface in human aortic endothelial cells

Scientific Reports
AKT (protein kinase B) activation reduces the harmful effects of advanced glycation end products (AGEs); however, the protective mechanisms remain unknown.
Chung Hee Baek, Hyosang Kim, Soo Young Moon, Eun Kyoung Lee, Won Seok Yang   +4 more
doaj   +1 more source

Long Non-Coding RNA LUCAT1 Promotes Progression of Thyroid Carcinoma by Reinforcing ADAM10 Expression Through Sequestering microRNA-493

International Journal of General Medicine, 2020
Guofeng Xiong,1,2 Jiaming Chen,1 Zhen Wu,1 Shizhi He,1 Meng Lian,1 Jugao Fang1 1Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, People’s Republic of China; 2Department ...
Xiong G, Chen J, Wu Z, He S, Lian M, Fang J   +5 more
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