Results 91 to 100 of about 22,161 (218)

Role of ADAM17 in the non-cell autonomous effects of oncogene-induced senescence [PDF]

, 2015
Proteomic analysis of the secretome of p95HER2-induced senescence. a MCF7 Tet-Off p95HER2 cells were cultured with or without doxycycline for 1 week and stained for senescence-associated β-galactosidase.
Arribas, Joaquín V, Martínez-Barriocanal, Águeda, Morancho, Beatriz, Universitat Autònoma de Barcelona, Villanueva, Josep   +4 more
core   +2 more sources

Enhancing α-secretase Processing for Alzheimer’s Disease—A View on SFRP1

Brain Sciences, 2020
Amyloid β (Aβ) peptides generated via sequential β- and γ-secretase processing of the amyloid precursor protein (APP) are major etiopathological agents of Alzheimer’s disease (AD).
Bor Luen Tang
doaj   +1 more source

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model. [PDF]

, 2019
Many risk genes for the development of Alzheimer's disease (AD) are exclusively or highly expressed in myeloid cells. Microglia are dependent on colony-stimulating factor 1 receptor (CSF1R) signaling for their survival.
Bollag, Gideon, Broome, Stephanie, Burton, Elizabeth A, Crapser, Joshua, Green, Kim N, Habets, Gaston, Hohsfield, Lindsay A, Ibrahim, Prabha, Lin, Jack, Nespi, Marika, Phan, Nicole Y, Rymar, Andrey, Severson, Paul L, Singh, Parmveer, Spangenberg, Elizabeth, Spevak, Wayne, Tsang, Garson, Walters, Jason, West, Brian L, Zhang, Chao, Zhang, Jiazhong, Zhang, Ying   +21 more
core  

Global Characterization of Protein Secretion from Human Macrophages Following Non-canonical Caspase-4/5 Inflammasome Activation [PDF]

, 2017
Gram-negative bacteria are associated with a wide spectrum of infectious diseases in humans. Inflammasomes are cytosolic protein complexes that are assembled when the cell encounters pathogens or other harmful agents.
Angus, Baker, Chakrabarti, Chen, Cypryk, Cypryk, Hagar, He, Hikita, Horiuchi, Hotamisligil, Kayagaki, Kaye, Lampinen, Lee, Lemaitre, Lietzén, Medzhitov, Meissner, Mohr, Mosoian, O'Connell, Ohman, Pirhonen, Poltorak, Pruenster, Qiu, Rabouille, Raposo, Rayamajhi, Romani, Saftig, Schroder, Shi, Storek, Szklarczyk, Vizcaíno, Vogl, Välimäki, Välimäki, Yang, Zanoni, Zhang, Zhu, Öhman   +44 more
core   +1 more source

Genome‐Wide Association Studies for 24 Hematological Traits in Production Pigs Before and After Weaning

Animal Genetics, Volume 57, Issue 2, April 2026.
ABSTRACT Hematological traits are essential indicators of an animal's immune status and overall health, reflecting both physiological and pathological conditions. The complete blood count (CBC), a commonly used clinical test, evaluates the concentrations, proportions, and characteristics of various blood cell parameters, providing insights into an ...
Jiahong Sun, Emil Ibragimov, Malene Kjelin Morsing, Martin Peter Rydal, Lise Nikolic Nielsen, Zexi Cai, Jens Peter Nielsen, Merete Fredholm, Peter Karlskov‐Mortensen   +8 more
wiley   +1 more source

Amyloid and intracellular accumulation of BRI2 [PDF]

, 2017
Familial British dementia (FBD) and familial Danish dementia (FDD) are caused by mutations in the BRI2 gene. These diseases are characterized clinically by progressive dementia and ataxia and neuropathologically by amyloid deposits and neurofibrillary ...
Garringer, Holly J., Ghetti, Bernardino, Oblak, Adrian, Sammeta, Neeraja, Vidal, Ruben   +4 more
core   +1 more source

AS1842856 Reduces β‐Amyloid Burden via Inhibiting PLA2G4A‐Mediated Lysosomal Dysfunction in APP/PS1 Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
AS1842856 reduces intracellular levels of GSK3α/β by binding to them and promoting their exocytosis. This reduction leads to diminished GSK3β‐mediated activation of NF‐κB, resulting in decreased transcription of PLA2G4A and reduced lysosomal damage. Ultimately, this enhances lysosomal degradation of Aβ, lowering Aβ load in APP/PS1 mice.
Da‐Long He, Zheng Wu, Rong‐Jun Jia, Ting‐Yao Wu, Yi‐Min Qiu, Yong‐Gang Fan   +5 more
wiley   +1 more source

Clinical significance of ADAM10 expression in laryngeal carcinoma

Oncology Letters, 2016
Recent findings suggest that upregulated a disintegrin and metalloproteinase (ADAM)10 expression participates in the progression of multiple types of cancer. However, the expression pattern and clinicopathological significance of ADAM10, and its potential prognostic role in laryngeal carcinoma remains to be explored.
Bo, You, Miao, Gu, Xiaolei, Cao, Xingyu, Li, Si, Shi, Ying, Shan, Yiwen, You   +6 more
openaire   +3 more sources

Development of Anti‐Inflammatory Extracellular Vesicles by Surface Expression of Syndecan‐4

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT The biological functions of extracellular vesicles (EVs) depend on their cellular source. Further, different subpopulations of EVs from the same cells carry different cargo, but differences in their biological functions are less understood. We here identify a very small EV subpopulation released by HEK293F cells (miniEVs).
Lijuan Yu, Markus Bergqvist, Kyong‐Su Park, Cecilia Lässer, Jan Lötvall   +4 more
wiley   +1 more source

ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance

OncoImmunology, 2020
ADAM10 and ADAM17 expression and soluble PD-L1 (sPD-L1) predict poor prognosis in many malignancies, including in patients treated with PD-(L)1 inhibitors. The mechanism of soluble PD-L1 production and its effects are unknown.
Jacob J. Orme, Khalid A. Jazieh, Tiancheng Xie, Susan Harrington, Xin Liu, Matthew Ball, Benjamin Madden, M. Cristine Charlesworth, Tariq U. Azam, Fabrice Lucien, Bharath Wootla, Yanli Li, Jose Caetano Villasboas, Aaron S. Mansfield, Roxana S. Dronca, Haidong Dong   +15 more
doaj   +1 more source