Results 71 to 80 of about 22,161 (218)

In Search of Selectivity in Inhibition of ADAM10 [PDF]

ACS Medicinal Chemistry Letters, 2018
The metalloproteinase ADAM10 has been reported as an important target for drug discovery in several human diseases. In this vein, (6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazine-1-carbonyl)-5-azaspiro[2.5]octane-7-carboxamide (compound 1) has been reported as a selective ADAM10 inhibitor.
Kiran V. Mahasenan, Derong Ding, Ming Gao, Trung T. Nguyen, Mark A. Suckow, Valerie A. Schroeder, William R. Wolter, Mayland Chang, Shahriar Mobashery   +8 more
openaire   +2 more sources

Differential expression of “A Disintegrin and Metalloproteinase 10” in hepatocellular carcinoma and the noncancerous hepatic tissues: Contribution to HCV-promoted hepatocarcinogenesis

Indian Journal of Pathology and Microbiology, 2023
Background: A disintegrin and metalloproteinases (ADAMs) have emerged as therapeutic targets in many cancers. ADAM10 was particularly studied in hepatocellular carcinoma (HCC) for its potential role in hepatocarcinogenesis and HCC progression. Objective:
Amal Abd El Hafez, Basem H. Elesawy, Heba S. E. I. Hany   +2 more
doaj   +1 more source

Secreted frizzled related proteins modulate pathfinding and fasciculation of mouse retina ganglion cell axons by direct and indirect mechanisms [PDF]

, 2015
Retina ganglion cell (RGC) axons grow along a stereotyped pathway undergoing coordinated rounds of fasciculation and defasciculation, which are critical to establishing proper eye– brain connections.
Bovolenta, Paola, Cardozo, Marcos Julian, Di Marco, Fabiana, Esteve, Pilar, Marcos, Séverine, Nieto-Lopez, Francisco, Sandonìs, Africa   +6 more
core   +2 more sources

The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis

British Journal of Pharmacology, EarlyView.
Background and Purpose Acute pancreatitis (AP) is a multifactorial upper gastrointestinal inflammatory disorder that in severe cases (~20% of all AP) is associated with substantial morbidity and mortality, the latter coincident with multiorgan dysfunction, particularly acute lung injury (ALI).
Shermin Chan, Karen Hon, Ruby E. Dawson, Teresa Weng, Jelena Solujic, Yu C. J. Chey, James D. Zuiani, Griffith B. Perkins, P. Toby Coates, Chris Drogemuller, Eddie Sanderlin, Lulu Huang, John Finnie, Stefan Rose‐John, Arash Badiei, Phan Nguyen, Brendan J. Jenkins, Mohamed I. Saad   +17 more
wiley   +1 more source

Disintegrin and metalloproteinases (ADAMs) expression in gastroesophageal reflux disease and in esophageal adenocarcinoma [PDF]

, 2016
Clinically useful marker molecules for the progression of gastroesophageal reflux disease and Barrett's esophagus (BE) to esophageal adenocarcinoma (EAC) are lacking. Many adenocarcinomas and inflammatory conditions exhibit increased expression of ADAMs,
Ilonen, I., Kauttu, T., Krogerus, L., Mustonen, H., Puolakkainen, P., Rasanen, J., Salo, J., Vainionpää, S.   +7 more
core   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Regulation of A disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: The emerging role of tetraspanins and rhomboids

Platelets, 2017
A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are ubiquitous transmembrane “molecular scissors” which proteolytically cleave, or shed, the extracellular regions of other transmembrane proteins.
Alexandra L. Matthews, Peter J. Noy, Jasmeet S. Reyat, Michael G. Tomlinson   +3 more
doaj   +1 more source

Shifting the balance: soluble ADAM10 as a potential treatment for Alzheimer's disease

Frontiers in Aging Neuroscience, 2023
IntroductionAccumulation of amyloid β in the brain is regarded as a key initiator of Alzheimer's disease pathology. Processing of the amyloid precursor protein (APP) in the amyloidogenic pathway yields neurotoxic amyloid β species.
Ayelet Sarah Hershkovits, Ayelet Sarah Hershkovits, Sivan Gelley, Rawad Hanna, Oded Kleifeld, Avidor Shulman, Ayelet Fishman   +6 more
doaj   +1 more source

Evaluation of gene-based family-based methods to detect novel genes associated with familial late onset Alzheimer disease [PDF]

, 2018
Gene-based tests to study the combined effect of rare variants towards a particular phenotype have been widely developed for case-control studies, but their evolution and adaptation for family-based studies, especially for complex incomplete families ...
Budde, John, Cruchaga, Carlos, Del-Aguila, Jorge L, Deming, Yuetiva, Fernandez, Maria V, Goate, Alison M, Harari, Oscar, Ibanez, Laura, Morris, John C, NCRAD,, NIA-LOAD family study group,, Norton, Joanne   +11 more
core   +2 more sources

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source