Results 1 to 10 of about 22,445 (222)
Transcription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxia [PDF]
Journal of Experimental & Clinical Cancer Research, 2009 Background Expression of the Sp1 transcription factor is induced by hypoxia, and the ADAM17 promoter contains predicted Sp1 binding sites. ADAM17 contributes to hypoxic-induce invasiveness of glioma.
Jiang Feng +4 more
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Strategies to Target ADAM17 in Disease: From Its Discovery to the iRhom Revolution
Molecules, 2021 For decades, disintegrin and metalloproteinase 17 (ADAM17) has been the object of deep investigation. Since its discovery as the tumor necrosis factor convertase, it has been considered a major drug target, especially in the context of inflammatory ...
Doretta Cuffaro +2 more
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ADAM17-dependent Autocrine and Paracrine Signaling Promotes Pancreatic Premalignant ProgressionSummaryWhat You Need to Know [PDF]
Cellular and Molecular Gastroenterology and HepatologyBackground & Aims: A Disintegrin and Metalloproteinase 17 (ADAM17) is a membrane-bound sheddase that regulates the release of multiple signaling molecules, including inflammatory mediators and epidermal growth factor receptor (EGFR) ligands.
Hui-Ju Wen +14 more
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ADAM17 as a promising therapeutic target: from structural basis to inhibitor discovery in human diseases [PDF]
Frontiers in PharmacologyA disintegrin and metalloproteinase 17 (ADAM17) is a transmembrane protease that regulates diverse physiological processes by shedding membrane-bound proteins, including cytokines, their receptors, and adhesion molecules.
Lisa Liu +8 more
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Targeting ADAM17 to dampen dendritic cell-mediated type 2 immune responses and airway inflammation associated with allergic asthma [PDF]
Scientific ReportsThe zinc containing matrix metalloproteinase enzyme regulates a diverse array of biological processes in health and disease, including ADAM17 (a disintegrin and metalloproteinase domain 17) enzyme.
Anil Kumar Jaiswal +2 more
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Frontiers in Pharmacology, 2022 A disintegrin and metalloprotease domain family protein 17 (ADAM17) is a new member of renin-angiotensin system (RAS) but its role in the pathogenesis of diabetic cardiomyopathy (DCM) is obscure.
Jing Cheng +20 more
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Frontiers in Immunology, 2022 Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) is a ubiquitously expressed membrane-bound enzyme that mediates shedding of a wide variety of important regulators in inflammation including cytokines and adhesion molecules. Hepatic
Wagdi Almishri +7 more
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Immunomodulatory role of metalloproteinase ADAM17 in tumor development
Frontiers in Immunology, 2022 ADAM17 is a member of the a disintegrin and metalloproteinase (ADAM) family of transmembrane proteases involved in the shedding of some cell membrane proteins and regulating various signaling pathways.
Kai Wang +5 more
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Cells, 2022 Ectodomain shedding is an irreversible process to regulate inter- and intracellular signaling. Members of the a disintegrin and metalloprotease (ADAM) family are major mediators of ectodomain shedding.
Miryam Müller +10 more
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ADAM17 silencing in mouse colon carcinoma cells: the effect on tumoricidal cytokines and angiogenesis. [PDF]
PLoS ONE, 2012 ADAM17 (a disintegrin and metalloprotease 17) is a major sheddase for numerous growth factors, cytokines, receptors, and cell adhesion molecules and is often overexpressed in malignant cells.
Sudipta Das +13 more
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